Journal ArticleDOI
Antimicrobial activity of metals: mechanisms, molecular targets and applications
Reads0
Chats0
TLDR
The chemical and toxicological principles that underlie the antimicrobial activity of metals are described and the preferences of metal atoms for specific microbial targets are discussed.Abstract:
Metals have been used as antimicrobial agents since antiquity, but throughout most of history their modes of action have remained unclear. Recent studies indicate that different metals cause discrete and distinct types of injuries to microbial cells as a result of oxidative stress, protein dysfunction or membrane damage. Here, we describe the chemical and toxicological principles that underlie the antimicrobial activity of metals and discuss the preferences of metal atoms for specific microbial targets. Interdisciplinary research is advancing not only our understanding of metal toxicity but also the design of metal-based compounds for use as antimicrobial agents and alternatives to antibiotics.read more
Citations
More filters
Journal ArticleDOI
Synthesis, characterization, applications, and challenges of iron oxide nanoparticles
Attarad Ali,Hira Zafar,Muhammad Zia,Ihsan-ul Haq,Abdul Rehman Phull,Joham Sarfraz Ali,Altaf Hussain +6 more
TL;DR: This review summarizes the methods for the preparation of iron oxide NPs, size and morphology control, and magnetic properties with recent bioengineering, commercial, and industrial applications.
Book ChapterDOI
Chapter One – Mineral–Organic Associations: Formation, Properties, and Relevance in Soil Environments
Markus Kleber,Karin Eusterhues,Marco Keiluweit,Christian Mikutta,Robert Mikutta,Peter S. Nico +5 more
TL;DR: An overview of the current knowledge on mineral-organic associations can be found in this article, where the authors identify key questions and future research needs, as well as a survey of the existing research work.
Journal ArticleDOI
Antibacterial Activity of Ti3C2Tx MXene
TL;DR: The antibacterial properties of single- and few-layer Ti3C2Tx MXene flakes in colloidal solution were investigated and showed a higher antibacterial efficiency toward both Gram-negative E. coli and Gram-positive B. subtilis compared with graphene oxide (GO), which has been widely reported as an antibacterial agent.
Journal ArticleDOI
Nanosilver-based antibacterial drugs and devices: Mechanisms, methodological drawbacks, and guidelines
Loris Rizzello,Pier Paolo Pompa +1 more
TL;DR: This review analyzes the experimental data on the bactericidal effects of AgNPs, discussing the complex scenario and presenting the potential drawbacks and limitations in the techniques and methods employed, and proposes some general guidelines for the design of antibacterial nanosystems and devices based on nanosilver.
Journal ArticleDOI
Bacterial resistance to silver nanoparticles and how to overcome it.
Aleš Panáček,Libor Kvítek,Monika Smékalová,Renata Večeřová,Milan Kolář,Magdaléna Röderová,Filip Dyčka,Marek Šebela,Robert Prucek,Ondřej Tomanec,Radek Zbořil +10 more
TL;DR: It is reported that the Gram-negative bacteria Escherichia coli 013, Pseudomonas aeruginosa CCM 3955 and E. coli CCM 3954 can develop resistance to silver nanoparticles after repeated exposure, and the resistance mechanism cannot be overcome by additional stabilization ofsilver nanoparticles using surfactants or polymers.
References
More filters
Journal ArticleDOI
Hard and soft acids and bases
TL;DR: In this paper, the rate data for the generalized nucleophilic displacement reaction were reviewed, and the authors presented a method to estimate the rate of the generalized displacement reaction in terms of the number of nucleophiles.
Journal ArticleDOI
Absolute hardness: companion parameter to absolute electronegativity
Robert G. Parr,Ralph G. Pearson +1 more
TL;DR: In this paper, a property called absolute hardness eta is defined for neutral and charged species, atomic and molecular, for both hard and soft acids and bases, by making use of the hypothesis that extra stability attends bonding of A to B when the ionization potentials of A and B in the molecule are the same.
Journal ArticleDOI
Shape-Controlled Synthesis of Gold and Silver Nanoparticles
Yugang Sun,Younan Xia +1 more
TL;DR: Monodisperse samples of silver nanocubes were synthesized in large quantities by reducing silver nitrate with ethylene glycol in the presence of poly(vinyl pyrrolidone) (PVP), characterized by a slightly truncated shape bounded by {100, {110}, and {111} facets.
Journal ArticleDOI
Free radicals, metals and antioxidants in oxidative stress-induced cancer
TL;DR: This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors.
Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.