Journal ArticleDOI
Antimicrobial activity of metals: mechanisms, molecular targets and applications
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TLDR
The chemical and toxicological principles that underlie the antimicrobial activity of metals are described and the preferences of metal atoms for specific microbial targets are discussed.Abstract:
Metals have been used as antimicrobial agents since antiquity, but throughout most of history their modes of action have remained unclear. Recent studies indicate that different metals cause discrete and distinct types of injuries to microbial cells as a result of oxidative stress, protein dysfunction or membrane damage. Here, we describe the chemical and toxicological principles that underlie the antimicrobial activity of metals and discuss the preferences of metal atoms for specific microbial targets. Interdisciplinary research is advancing not only our understanding of metal toxicity but also the design of metal-based compounds for use as antimicrobial agents and alternatives to antibiotics.read more
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Journal ArticleDOI
The aminoglycoside resistance-promoting AmgRS envelope stress-responsive two-component system in Pseudomonas aeruginosa is zinc-activated and protects cells from zinc-promoted membrane damage.
TL;DR: Exposure of wild-type (WT) Pseudomonas aeruginosa PAO1 to ZnCl2 yielded a concentration-dependent increase in depolarization of the cytoplasmic membrane (CM), an indication that this metal is membrane-damaging.
Journal ArticleDOI
Influence of Bi addition on the property of Ag-Bi nano-composite coatings
TL;DR: In this article, the microstructure, mechanical properties, electrical conductivity and antibacterial behavior of the resulting coating was performed, and the results indicated that after adding an appropriate amount of Bi containing solution into the Ag plating solution, Ag-Bi nanoparticles were in-situ formed and distributed uniformly throughout the coating matrix, resulting in a significant improvement in the mechanical properties.
Book ChapterDOI
Nanometals appraisal in food preservation and food-related activities
TL;DR: In this article, the potential advantages and drawbacks of nanometals in food preservation are discussed, considering the potential benefits and potential risks of using nanometal supplements in the food industry.
Journal ArticleDOI
High-Resolution Microscopical Studies of Contact Killing Mechanisms on Copper-Based Surfaces.
Tingru Chang,Tingru Chang,R. Prasath Babu,Weijie Zhao,C. Magnus Johnson,Peter Hedström,Inger Odnevall,Inger Odnevall,Christofer Leygraf +8 more
TL;DR: In this article, the authors explored the mechanisms of bacterial contact killing induced by Cu surfaces through high-resolution studies based on combinations of the focused ion beam (FIB), scanning transmission electron microscopy (STEM), high resolution TEM, and nanoscale Fourier transform infrared spectroscopy (nano-FTIR) microscopy of individual bacterial cells.
Journal ArticleDOI
Tellurite and Selenite: how can these two oxyanions be chemically different yet so similar in the way they are transformed to their metal forms by bacteria?
TL;DR: In this article , the authors explore the microbiology of tellurite, TeO32- and selenite, SeO32 - oxyanions, two similar Group 16 chalcogen elements, but with slightly different physicochemical properties that lead to intriguing biological differences.
References
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Journal ArticleDOI
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Journal ArticleDOI
Shape-Controlled Synthesis of Gold and Silver Nanoparticles
Yugang Sun,Younan Xia +1 more
TL;DR: Monodisperse samples of silver nanocubes were synthesized in large quantities by reducing silver nitrate with ethylene glycol in the presence of poly(vinyl pyrrolidone) (PVP), characterized by a slightly truncated shape bounded by {100, {110}, and {111} facets.
Journal ArticleDOI
Free radicals, metals and antioxidants in oxidative stress-induced cancer
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Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.