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Antimicrobial activity of metals: mechanisms, molecular targets and applications

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TLDR
The chemical and toxicological principles that underlie the antimicrobial activity of metals are described and the preferences of metal atoms for specific microbial targets are discussed.
Abstract
Metals have been used as antimicrobial agents since antiquity, but throughout most of history their modes of action have remained unclear. Recent studies indicate that different metals cause discrete and distinct types of injuries to microbial cells as a result of oxidative stress, protein dysfunction or membrane damage. Here, we describe the chemical and toxicological principles that underlie the antimicrobial activity of metals and discuss the preferences of metal atoms for specific microbial targets. Interdisciplinary research is advancing not only our understanding of metal toxicity but also the design of metal-based compounds for use as antimicrobial agents and alternatives to antibiotics.

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Citations
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A Liquid Metal Mediated Metallic Coating for Antimicrobial and Antiviral Fabrics

TL;DR: In this article, an easy-to-control and straightforward method is reported to coat a wide range of fabrics by using gallium liquid metal (LM) particles to facilitate the deposition of liquid metal copper alloy (LMCu) particles.
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Large-area chemical vapor deposition-grown monolayer graphene-wrapped silver nanowires for broad-spectrum and robust antimicrobial coating

TL;DR: In this paper, a broad-spectrum and robust antimicrobial thin film coating based on large-area chemical vapor deposition (CVD)-grown graphene-wrapped silver nanowires (AgNWs) was developed for the first time.
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Copper tolerance mechanisms of Mesorhizobium amorphae and its role in aiding phytostabilization by Robinia pseudoacacia in copper contaminated soil.

TL;DR: Results showed that a copA deletion did not affect the symbiotic capacity of rhizobia under uncontaminated condition, but the protective role of copA in symbiotic processes at high copper concentration is likely concentration-dependent.
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Surface-Anchored Poly(4-vinylpyridine)–Single-Walled Carbon Nanotube–Metal Composites for Gas Detection

TL;DR: A platform for chemiresistive gas detectors based upon single-walled carbon nanotube (SWCNT) dispersions stabilized by poly(4-vinylpyridine) (P4VP) covalently immobilized onto a glass substrate was developed as discussed by the authors.
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Self-powered active antibacterial clothing through hybrid effects of nanowire-enhanced electric field electroporation and controllable hydrogen peroxide generation

TL;DR: In this article, a self-powered active disinfection system controlled by human motions is proposed. But the system is mainly composed of a multilayered triboelectric nanogenerator (m-TENG) for the harvesting of biomechanical energy and conductive fabrics as electrodes for the wearable disinfection.
References
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Journal ArticleDOI

Hard and soft acids and bases

TL;DR: In this paper, the rate data for the generalized nucleophilic displacement reaction were reviewed, and the authors presented a method to estimate the rate of the generalized displacement reaction in terms of the number of nucleophiles.
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Absolute hardness: companion parameter to absolute electronegativity

TL;DR: In this paper, a property called absolute hardness eta is defined for neutral and charged species, atomic and molecular, for both hard and soft acids and bases, by making use of the hypothesis that extra stability attends bonding of A to B when the ionization potentials of A and B in the molecule are the same.
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Shape-Controlled Synthesis of Gold and Silver Nanoparticles

TL;DR: Monodisperse samples of silver nanocubes were synthesized in large quantities by reducing silver nitrate with ethylene glycol in the presence of poly(vinyl pyrrolidone) (PVP), characterized by a slightly truncated shape bounded by {100, {110}, and {111} facets.
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Free radicals, metals and antioxidants in oxidative stress-induced cancer

TL;DR: This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors.
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The bactericidal effect of silver nanoparticles

TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
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