Journal ArticleDOI
Antimicrobial activity of metals: mechanisms, molecular targets and applications
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TLDR
The chemical and toxicological principles that underlie the antimicrobial activity of metals are described and the preferences of metal atoms for specific microbial targets are discussed.Abstract:
Metals have been used as antimicrobial agents since antiquity, but throughout most of history their modes of action have remained unclear. Recent studies indicate that different metals cause discrete and distinct types of injuries to microbial cells as a result of oxidative stress, protein dysfunction or membrane damage. Here, we describe the chemical and toxicological principles that underlie the antimicrobial activity of metals and discuss the preferences of metal atoms for specific microbial targets. Interdisciplinary research is advancing not only our understanding of metal toxicity but also the design of metal-based compounds for use as antimicrobial agents and alternatives to antibiotics.read more
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Biodegradable Tragacanth Gum Based Silver Nanocomposite Hydrogels and Their Antibacterial Evaluation
Kummara Madhusudhana Rao,Anuj Kumar,Kummri Subba Venkata Krishna Rao,Adnan Haider,Sung Soo Han +4 more
TL;DR: In this article, tragacanth gum (TG) biopolymer based silver nanocomposite hydrogels (SNCHs) were prepared with acrylamide as monomer using a simple redox polymerization method.
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Multimetallic Nanoparticles as Alternative Antimicrobial Agents: Challenges and Perspectives
TL;DR: In this article, the authors summarized research progress on the synergistic effect of multimetallic nanoparticles (NPs) as alternative antimicrobial agents for treating severe bacterial infections and highlighted recent promising innovations of multi-metallic NPs that help overcome antimicrobial resistance.
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Prevalence of fluoroquinolone, macrolide and sulfonamide-related resistance genes in landfills from East China, mainly driven by MGEs.
TL;DR: Quantifying three classes of antibiotics, six kinds of heavy metals, eight types of ARGs, and five varieties of mobile genetic elements in refuse samples from 10 landfills in Zhejiang Province, China reveals high levels of ARG and the ubiquitous presence of antibiotics in refuse, but also provides guidance for controlling the spread ofARGs in landfilling.
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In-situ reduction of monodisperse nanosilver on hierarchical wrinkled mesoporous silica with radial pore channels and its antibacterial performance
TL;DR: Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) test indicated that the obtained products can achieve durable and much better antibacterial performance both against Gram-negative bacterium Escherichia coli and Gram-positive bacterium Staphylococcus aureus.
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Inoculation of bacteria for the bioremediation of heavy metals contaminated soil by Agrocybe aegerita
TL;DR: In this article, a combination of mushrooms and bacteria was used as a novel technique to remediate soils polluted by heavy metals, and Pot experiments were conducted to investigate combined effects of Agrocybe aegerita and Serratia spp.
References
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Journal ArticleDOI
Hard and soft acids and bases
TL;DR: In this paper, the rate data for the generalized nucleophilic displacement reaction were reviewed, and the authors presented a method to estimate the rate of the generalized displacement reaction in terms of the number of nucleophiles.
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Absolute hardness: companion parameter to absolute electronegativity
Robert G. Parr,Ralph G. Pearson +1 more
TL;DR: In this paper, a property called absolute hardness eta is defined for neutral and charged species, atomic and molecular, for both hard and soft acids and bases, by making use of the hypothesis that extra stability attends bonding of A to B when the ionization potentials of A and B in the molecule are the same.
Journal ArticleDOI
Shape-Controlled Synthesis of Gold and Silver Nanoparticles
Yugang Sun,Younan Xia +1 more
TL;DR: Monodisperse samples of silver nanocubes were synthesized in large quantities by reducing silver nitrate with ethylene glycol in the presence of poly(vinyl pyrrolidone) (PVP), characterized by a slightly truncated shape bounded by {100, {110}, and {111} facets.
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Free radicals, metals and antioxidants in oxidative stress-induced cancer
TL;DR: This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors.
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The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.