Association of E484K spike protein mutation with SARS-CoV-2 infection in vaccinated persons---Maryland, January - May 2021.
Kenneth A. Feder,Ami Patel,Venkata R. Vepachedu,Catherine Dominguez,Eric N. Keller,Liore Klein,Curi Kim,Tim Blood,Judie Hyun,Thelonious W. Williams,Katherine A. Feldman,Heba H. Mostafa,C. Paul Morris,Jacques Ravel,Monique Duwell,David Blythe,Robert W. Myers +16 more
TLDR
Among 9,048 people infected with SARS-CoV-2 between January-May- 2021 in Maryland, in regression-adjusted analysis, the spike protein mutation E484K was disproportionately prevalent among persons infected after full vaccination against COVID-19 as compared to infected persons who were not fully vaccinated as discussed by the authors.Abstract:
Among 9,048 people infected with SARS-CoV-2 between January-May, 2021 in Maryland, in regression-adjusted analysis, SARS-CoV-2 viruses carrying the spike protein mutation E484K were disproportionately prevalent among persons infected after full vaccination against COVID-19 as compared to infected persons who were not fully vaccinated (aOR 1.96, 95% CI, 1.36 to 2.83).read more
Citations
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COVID-19 Variant Detection with a High-Fidelity CRISPR-Cas12 Enzyme
Sihai Guan,Kai Fu +1 more
TL;DR: In this article , a rapid COVID-19 variant DETECTR assay incorporating loop-mediated isothermal amplification (LAMP) followed by CRISPR-Cas12 based identification of single nucleotide polymorphism (SNP) mutations in the SARS-CoV-2 spike (S) gene was presented.
Posted ContentDOI
A case series of SARS-CoV-2 reinfections caused by the variant of concern Gamma in Brazil
Felipe Gomes Naveca,Valdinete Alves do Nascimento,Fernanda Nascimento,Maria Ogrzewalska,Alex Pauvolid-Corrêa,Mia Ferreira Araujo,Ighor Arantes,erika Lopes Rocha Batista,Alessandro Leonardo lvares Magalhaes,Fernando Vinhal,Tirza Mattos,Irina Nastassja Riediger,Maria do Carmo Debur,Beatriz Grinsztejn,Valdilea G. Veloso,Patrícia Brasil,Rodrigo Ribeiro Rodrigues,Darcita Buerger Rovaris,Sandra Fernandes,Cristiano Fernandes,João Hugo Abdalla Santos,Ligia Fernandes Abdalla,Rubens Costa-Filho,Marineide Silva,Victor Costa de Souza,gatha Araujo Costa,Matilde Mejía,Maria Júlia Brandão,Luciana Fe Goncalves,George Silva,Michele Silva de Jesus,Karina Pessoa,André de Lima Guerra Corado,Débora Duarte,Ana Beatriz Machado,Ketiuce de Azevedo Zukeram,Natalia Valente,Renata Serrano Lopes,Elisa Cavalcante Pereira,Luciana Appolinario,Alice Sampaio Barreto da Rocha,Luis Fernando Lopez Tort,Tsuyoshi Sekizuka,Kentaro Itokawa,Masanori Hashino,Makoto Kuroda,Gabriel Luz Wallau,Edson Delatorre,Tiago Gräf,Marilda M. Siqueira,Gonzalo Bello,Paola Cristina Resende +51 more
TL;DR: In this article, the authors describe 25 cases of SARS-CoV-2 reinfection confirmed by real-time RT-PCR twice within months apart in Brazil and demonstrate that the VOC Gamma was associated with reinfections during the second Brazilian epidemic wave in 2021 and raised concern about the potential infectiousness of reinfected subjects.
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The (apparent) antibody paradox in COVID-19
TL;DR: The role of antibodies in COVID-19 remains to be fully defined as discussed by the authors , however, it is increasingly clear that the virus triggers an inappropriate host inflammatory reaction in patients experiencing severe disease.
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Receptor binding domain proteins of SARS‐CoV‐2 variants produced in Nicotiana benthamiana elicit neutralizing antibodies against variants of concern
Narach Khorattanakulchai,Suwimon Manopwisedjaroen,Kaewta Rattanapisit,Chalisa Panapitakkul,Taratorn Kemthong,Nutchanat Suttisan,Kanjana Srisutthisamphan,Suchinda Malaivijitnond,A. Thitithanyanont,Anan Jongkaewwattana,Balamurugan Shanmugaraj,Waranyoo Phoolcharoen +11 more
TL;DR: The results showed that three doses of the RBD‐Fc vaccine significantly enhanced the immune response against all tested SARS‐CoV‐2 variants, and these proof‐of‐concept results will be helpful for the development of plant‐derived RBD-Fc‐based vaccines against Sars‐Cov‐2 and its variants.
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Large Scale SARS-CoV-2 Molecular Testing and Genomic Surveillance Reveal Prolonged Infections, Protracted RNA shedding, and Viral Reinfections
C. Paul Morris,Chunmei Luo,Jaiprasath Sachithanandham,Maggie Li,Matthew D. Schwartz,David C. Gaston,Victoria Gniazdowski,Nicolas Giraldo-Castillo,Adannaya Amadi,J. Norton,William F. Wright,Eili Y. Klein,Andrew Pekosz,Heba H. Mostafa +13 more
TL;DR: The value of integrating genomic, laboratory, and clinical data for understanding the biology of SARS-CoV-2 as well as for setting a precedent for future epidemics and pandemics is highlighted.
References
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