Biomaterial-driven in situ cardiovascular tissue engineering : a multi-disciplinary perspective
TLDR
The main current challenges for in situ cardiovascular regeneration are pinpointed and further address, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.Abstract:
There is a persistent and growing clinical need for readily-available substitutes for heart valves and small-diameter blood vessels. In situ tissue engineering is emerging as a disruptive new technology, providing ready-to-use biodegradable, cell-free constructs which are designed to induce regeneration upon implantation, directly in the functional site. The induced regenerative process hinges around the host response to the implanted biomaterial and the interplay between immune cells, stem/progenitor cell and tissue cells in the microenvironment provided by the scaffold in the hemodynamic environment. Recapitulating the complex tissue microstructure and function of cardiovascular tissues is a highly challenging target. Therein the scaffold plays an instructive role, providing the microenvironment that attracts and harbors host cells, modulating the inflammatory response, and acting as a temporal roadmap for new tissue to be formed. Moreover, the biomechanical loads imposed by the hemodynamic environment play a pivotal role. Here, we provide a multidisciplinary view on in situ cardiovascular tissue engineering using synthetic scaffolds; starting from the state-of-the art, the principles of the biomaterial-driven host response and wound healing and the cellular players involved, toward the impact of the biomechanical, physical, and biochemical microenvironmental cues that are given by the scaffold design. To conclude, we pinpoint and further address the main current challenges for in situ cardiovascular regeneration, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.read more
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References
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Current progress in tissue engineering of heart valves: multiscale problems, multiscale
TL;DR: In this paper, a review of tissue engineering strategies in fabricating living heart valves and their progress towards the clinic is presented, including molded scaffolds using naturally derived or synthetic polymers, decellularization, electrospinning, 3D bioprinting, hybrid techniques and in vivo engineering.
Journal ArticleDOI
Advantages of bilayered vascular grafts for surgical applicability and tissue regeneration
S de Valence,Jean-Christophe Tille,Jean-Pierre Giliberto,Wojciech Mrówczyński,Robert Gurny,Beat H. Walpoth,Michael Möller +6 more
TL;DR: By tailoring the microarchitecture of biodegradable vascular prostheses, it is possible to optimize the scaffold for tissue regeneration while preventing blood leakage, and thus facilitating applicability in the clinic.
Journal ArticleDOI
The influence of gender on human innate immunity
TL;DR: It is hypothesized that the gender differences in clinical outcome are due to measurable differences in cytokine responses and intracellular signaling, and these differences are independent of polymorphism carrier status.
Journal ArticleDOI
6-month aortic valve implantation of an off-the-shelf tissue-engineered valve in sheep.
Zeeshan H. Syedain,Jay Reimer,Jillian B. Schmidt,Matthew T. Lahti,James M. Berry,Richard W. Bianco,Robert T. Tranquillo +6 more
TL;DR: Long-term implantation in the sheep model resulted in functionality, matrix remodeling, and recellularization, unprecedented results for a tissue-engineered aortic valve.
Journal ArticleDOI
Cell–cell signaling in co-cultures of macrophages and fibroblasts
TL;DR: Higher in vitro fidelity to FBR-like responses was found in primary cell co- Cultures compared to their mono-cultures and all secondary cell cultures, and in general higher in vivo fidelity to in vivo inflammatory signaling was found.
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