Biomaterial-driven in situ cardiovascular tissue engineering : a multi-disciplinary perspective
TLDR
The main current challenges for in situ cardiovascular regeneration are pinpointed and further address, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.Abstract:
There is a persistent and growing clinical need for readily-available substitutes for heart valves and small-diameter blood vessels. In situ tissue engineering is emerging as a disruptive new technology, providing ready-to-use biodegradable, cell-free constructs which are designed to induce regeneration upon implantation, directly in the functional site. The induced regenerative process hinges around the host response to the implanted biomaterial and the interplay between immune cells, stem/progenitor cell and tissue cells in the microenvironment provided by the scaffold in the hemodynamic environment. Recapitulating the complex tissue microstructure and function of cardiovascular tissues is a highly challenging target. Therein the scaffold plays an instructive role, providing the microenvironment that attracts and harbors host cells, modulating the inflammatory response, and acting as a temporal roadmap for new tissue to be formed. Moreover, the biomechanical loads imposed by the hemodynamic environment play a pivotal role. Here, we provide a multidisciplinary view on in situ cardiovascular tissue engineering using synthetic scaffolds; starting from the state-of-the art, the principles of the biomaterial-driven host response and wound healing and the cellular players involved, toward the impact of the biomechanical, physical, and biochemical microenvironmental cues that are given by the scaffold design. To conclude, we pinpoint and further address the main current challenges for in situ cardiovascular regeneration, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.read more
Citations
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Journal ArticleDOI
Tissue response, macrophage phenotype, and intrinsic calcification induced by cardiovascular biomaterials: Can clinical regenerative potential be predicted in a rat subcutaneous implant model?
Madeline C. Cramer,Jordan T. Chang,Hongshuai Li,Aurelie Serrero,Mohammed S. El-Kurdi,Martijn Cox,Frederick J. Schoen,Stephen F. Badylak +7 more
TL;DR: In this paper, the authors used a subcutaneous rat model to compare the tissue response, including macrophage phenotype, remodeling potential, and calcification propensity of a biologic scaffold composed of glutaraldehyde-fixed bovine pericardium (GF-BP), the standard of care for heart valve replacement, with those of an electrospun polycarbonate-based supramolecular polymer scaffold (ePC-UPy), urinary bladder extracellular matrix (UBM-ECM), and a polypropylene mesh (PP).
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Distinct Effects of Heparin and Interleukin-4 Functionalization on Macrophage Polarization and In Situ Arterial Tissue Regeneration Using Resorbable Supramolecular Vascular Grafts in Rats
Valentina Bonito,Suzanne E Koch,Merle M. Krebber,Daniel A Carvajal-Berrio,Julia Marzi,Renee Duijvelshoff,Emily B. Lurier,Emily B. Lurier,Serena Buscone,Sylvia Dekker,Simone M. J. de Jong,Tristan Mes,Koen R D Vaessen,Eva Brauchle,Anton W. Bosman,Katja Schenke-Layland,Marianne C. Verhaar,Patricia Y. W. Dankers,Anthal I.P.M. Smits,Carlijn V. C. Bouten +19 more
TL;DR: In this paper, the in vivo performance of electrospun resorbable elastomeric vascular grafts, dual-functionalized with anti-thrombogenic heparin (hep) and anti-inflammatory interleukin 4 (IL-4), was evaluated as interposition graft in the rat abdominal aorta.
Journal ArticleDOI
Mechanically tuned vascular graft demonstrates rapid endothelialization and integration into the porcine iliac artery wall.
Kaspars Maleckis,Alexey Kamenskiy,Eliezer Z. Lichter,Rebecca E. Oberley-Deegan,Yuris A. Dzenis,Jason MacTaggart +5 more
TL;DR: In this paper, an elastomeric nanofibrillar graft (ENG) with artery-tuned nonlinear compliance was developed and compared to conventional expanded polytetrafluoroethylene (ePTFE) grafts in a porcine iliac artery model.
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Effects of recipient age, heparin release and allogeneic bone marrow-derived stromal cells on vascular graft remodeling.
TL;DR: In this paper, the authors used vascular grafts consisting of core/shell-structured micro-fibers of polycaprolactone/gelatin with a thin polycaproactone overlay to assess the influence of the heparin release mode, animal age, and allogeneic bone marrow-derived stromal cells seeded in the lumen on the graft remodeling.
Journal ArticleDOI
Inflammatory and regenerative processes in bioresorbable synthetic pulmonary valves up to two years in sheep-Spatiotemporal insights augmented by Raman microspectroscopy.
B.J. de Kort,Julia Marzi,Eva-Maria Brauchle,A.M. Lichauco,Hannah Bauer,Aurelie Serrero,Sylvia Dekker,Martijn Cox,Frederick J. Schoen,Katja Schenke-Layland,Carlijn V. C. Bouten,Anthal I.P.M. Smits +11 more
TL;DR: In this article, the authors used a comprehensive histology and immunohistochemistry with Raman micro-spectroscopy for the spatiotemporal analysis of in situ tissue-engineered pulmonary valves with follow-up to 24 months from a previous preclinical study in sheep.
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