Biomaterial-driven in situ cardiovascular tissue engineering : a multi-disciplinary perspective
TLDR
The main current challenges for in situ cardiovascular regeneration are pinpointed and further address, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.Abstract:
There is a persistent and growing clinical need for readily-available substitutes for heart valves and small-diameter blood vessels. In situ tissue engineering is emerging as a disruptive new technology, providing ready-to-use biodegradable, cell-free constructs which are designed to induce regeneration upon implantation, directly in the functional site. The induced regenerative process hinges around the host response to the implanted biomaterial and the interplay between immune cells, stem/progenitor cell and tissue cells in the microenvironment provided by the scaffold in the hemodynamic environment. Recapitulating the complex tissue microstructure and function of cardiovascular tissues is a highly challenging target. Therein the scaffold plays an instructive role, providing the microenvironment that attracts and harbors host cells, modulating the inflammatory response, and acting as a temporal roadmap for new tissue to be formed. Moreover, the biomechanical loads imposed by the hemodynamic environment play a pivotal role. Here, we provide a multidisciplinary view on in situ cardiovascular tissue engineering using synthetic scaffolds; starting from the state-of-the art, the principles of the biomaterial-driven host response and wound healing and the cellular players involved, toward the impact of the biomechanical, physical, and biochemical microenvironmental cues that are given by the scaffold design. To conclude, we pinpoint and further address the main current challenges for in situ cardiovascular regeneration, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.read more
Citations
More filters
Journal ArticleDOI
Porous scaffolds for bone regeneration
TL;DR: This review focuses on the relationship between the porosity and pore size of scaffolds and subsequent osteogenesis, vascularisation and scaffold degradation during bone regeneration.
Journal ArticleDOI
Achieving Controlled Biomolecule–Biomaterial Conjugation
TL;DR: This review focuses on the chemistry of biomolecule conjugation and provides a comprehensive overview of the key strategies for achieving controlled biomaterial functionalization and highlights the importance of carefully considering the impact and suitability of a particular technique during biomaterial design.
Journal ArticleDOI
Minimally Invasive and Regenerative Therapeutics
Nureddin Ashammakhi,Samad Ahadian,Mohammad Ali Darabi,Mario El Tahchi,Junmin Lee,Kasinan Suthiwanich,Amir Sheikhi,Mehmet R. Dokmeci,Rahmi Oklu,Ali Khademhosseini +9 more
TL;DR: The use of MIRET to treat different tissues and organs and some clinical trials have been performed using MIRET, it is hoped that such therapeutics find wider applications to treat patients.
Journal ArticleDOI
Next-generation tissue-engineered heart valves with repair, remodelling and regeneration capacity
Emanuela S. Fioretta,Sarah E. Motta,Sarah E. Motta,Valentina Lintas,S Sandra Loerakker,Kevin Kit Parker,Frank P. T. Baaijens,Volkmar Falk,Simon P. Hoerstrup,Maximilian Y. Emmert +9 more
TL;DR: An unmet clinical need remains for valve replacements with regenerative, remodelling and growth potential, and next-generation tissue-engineered heart valves (TEHVs) are a promising therapeutic option for patients with valvular heart disease.
Journal ArticleDOI
Collagen-Based Tissue Engineering Strategies for Vascular Medicine.
Francesco Copes,Nele Pien,Nele Pien,Sandra Van Vlierberghe,Francesca Boccafoschi,Diego Mantovani +5 more
TL;DR: The current state of the art about the use of collagen-based strategies, mainly as a coating material for the functionalization of vascular graft luminal surface, as a drug delivery system for the release of pro-endothelialization factors, and as physiologically relevant in vitro vascular models, and the future trend in this field of research will be presented and discussed.
References
More filters
Journal ArticleDOI
Basic aspects of the regeneration of small-calibre neoarteries in biodegradable vascular grafts in rats.
TL;DR: It is concluded that vascular grafts, prepared from a material of optimal hydrophilicity, microporosity, compliance and rate of biodegradation, combined with smooth muscle and/or endothelial cell-seeding may provide a rapid development of a neoartery independent of the graft length.
Journal ArticleDOI
Conceptual model for early health technology assessment of current and novel heart valve interventions
Simone A. Huygens,Maureen P.M.H. Rutten-van Mölken,Jos A. Bekkers,Ad J.J.C. Bogers,Carlijn V. C. Bouten,Steven A. J. Chamuleau,Peter de Jaegere,Arie Pieter Kappetein,Jolanda Kluin,Nicolas M. Van Mieghem,Michel I.M. Versteegh,Maarten Witsenburg,Johanna J.M. Takkenberg +12 more
TL;DR: A conceptual model is developed that will serve as foundation of a decision-analytic model that can estimate the potential cost-effectiveness of TEHV in early development stages and identifies promising interventions that may result in faster take-up in clinical practice by clinicians and reimbursement by payers.
Journal ArticleDOI
Differential effects of uniaxial and biaxial strain on U937 macrophage-like cell morphology: influence of extracellular matrix type proteins.
TL;DR: Combined ECM/mechanical factors on the key signaling cells (macrophages) for wound healing, since previously, mechanical strain and ECM proteins have only been considered separately for their effects on macrophage morphology are investigated.
Journal ArticleDOI
Do Vascular Smooth Muscle Cells Differentiate to Macrophages in Atherosclerotic Lesions
TL;DR: The middle layer of the healthy vessel wall, the tunica media, contains an abundant population of vascular smooth muscle cells, and it is widely accepted that the dominant cell populating the atherosclerotic intima is the macrophage, a large myeloid leukocyte known for its proficiency at scavenging just about anything from bacteria to apoptotic cells to oxidized lipoproteins.
Journal ArticleDOI
Degree of scaffold degradation influences collagen (re)orientation in engineered tissues
de JongeNicky,FoolenJasper,C P BrugmansMarieke,H M SöntjensSerge,P T BaaijensFrank,V C BoutenCarlijn +5 more
TL;DR: It is hypothesized that in newly formed tissues, the collagen matrix does not yet provide contact guidance to the cells, and collagen orientation is altered via strain-induced remodeling.
Related Papers (5)
In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep.
Jolanda Kluin,Hanna Talacua,Anthal I.P.M. Smits,Maximilian Y. Emmert,Marieke Brugmans,Emanuela S. Fioretta,Petra E. Dijkman,Serge H. M. Söntjens,Renee Duijvelshoff,Sylvia Dekker,Marloes W J T Janssen-van den Broek,Valentina Lintas,Aryan Vink,Simon P. Hoerstrup,Simon P. Hoerstrup,Henk M. Janssen,Patricia Y. W. Dankers,Frank P. T. Baaijens,Carlijn V. C. Bouten +18 more
Off-the-shelf human decellularized tissue-engineered heart valves in a non-human primate model
Benedikt Weber,Petra E. Dijkman,Jacques Scherman,Bart Sanders,Maximilian Y. Emmert,Jürg Grünenfelder,Renier Verbeek,Mona Bracher,Melanie Black,Thomas Franz,Jeroen Kortsmit,Peter Modregger,Peter Modregger,Silvia Peter,Silvia Peter,Marco Stampanoni,Marco Stampanoni,Jerome Robert,Debora Kehl,Marina van Doeselaar,Martin Schweiger,Chad Brokopp,Thomas Wälchli,Thomas Wälchli,Volkmar Falk,Peter Zilla,Anita Anita Driessen-Mol,Frank P. T. Baaijens,Simon P. Hoerstrup +28 more