Biomaterial-driven in situ cardiovascular tissue engineering : a multi-disciplinary perspective
TLDR
The main current challenges for in situ cardiovascular regeneration are pinpointed and further address, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.Abstract:
There is a persistent and growing clinical need for readily-available substitutes for heart valves and small-diameter blood vessels. In situ tissue engineering is emerging as a disruptive new technology, providing ready-to-use biodegradable, cell-free constructs which are designed to induce regeneration upon implantation, directly in the functional site. The induced regenerative process hinges around the host response to the implanted biomaterial and the interplay between immune cells, stem/progenitor cell and tissue cells in the microenvironment provided by the scaffold in the hemodynamic environment. Recapitulating the complex tissue microstructure and function of cardiovascular tissues is a highly challenging target. Therein the scaffold plays an instructive role, providing the microenvironment that attracts and harbors host cells, modulating the inflammatory response, and acting as a temporal roadmap for new tissue to be formed. Moreover, the biomechanical loads imposed by the hemodynamic environment play a pivotal role. Here, we provide a multidisciplinary view on in situ cardiovascular tissue engineering using synthetic scaffolds; starting from the state-of-the art, the principles of the biomaterial-driven host response and wound healing and the cellular players involved, toward the impact of the biomechanical, physical, and biochemical microenvironmental cues that are given by the scaffold design. To conclude, we pinpoint and further address the main current challenges for in situ cardiovascular regeneration, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.read more
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References
More filters
Journal ArticleDOI
Gender specificity of altered human immune cytokine profiles in aging.
Edward J. Goetzl,Edward J. Goetzl,Mei Chuan Huang,Junko Kon,Kalpesh Patel,Janice B. Schwartz,Katharine Fast,Luigi Ferrucci,Karen Madara,Dennis D. Taub,Dan L. Longo +10 more
TL;DR: Cytokine generation by T cells and monocytes was determined for 50 subjects aged 65 yr or older and concurrently studied young subjects individually matched to each old subject for sex, race, and national origin to show gender specific differences.
Journal ArticleDOI
Controlled enzymatic degradation of poly(ɛ-caprolactone)-based copolymers in the presence of porcine pancreatic lipase
TL;DR: In this paper, a porcine pancreatic lipase (PP lipase) can effectively catalyze the degradation of PCD electrospun mats (EMs) with 92.0% weight loss within 7 days while it shows no detectable effect on PCL EMs.
Journal ArticleDOI
Biomechanical regulation of human monocyte/macrophage molecular function.
TL;DR: It is demonstrated that human monocytes/macrophages respond to mechanical deformation with selective augmentation of MMPs, induction of immediate early genes, and induction of the M-CSF receptor.
Journal ArticleDOI
In situ tissue engineering of functional small-diameter blood vessels by host circulating cells only
Hanna Talacua,Aipm Anthal Smits,Dep Dimitri Muylaert,Jan Willem van Rijswijk,A Aryan Vink,Marianne C. Verhaar,Anita Anita Driessen-Mol,Lex La van Herwerden,Carlijn V. C. Bouten,Jolanda Kluin,Frank Frank Baaijens +10 more
TL;DR: This study proves that functional blood vessels can be formed in situ through the host inflammatory response, specifically by blood-borne cells, and proves the regenerative potential of cells in the circulatory system in the setting of in situ vascular tissue engineering.
Journal ArticleDOI
Circumferentially aligned fibers guided functional neoartery regeneration in vivo.
Meifeng Zhu,Zhihong Wang,Jiamin Zhang,Lina Wang,Xiaohu Yang,Jingrui Chen,Guanwei Fan,Shenglu Ji,Cheng Xing,Wang Kai,Qiang Zhao,Yan Zhu,Deling Kong,Lianyong Wang +13 more
TL;DR: It is demonstrated that the circumferentially oriented VSMCs and longitudinally aligned ECs were successfully regenerated in vivo after the bi-layered vascular grafts were implanted in rat abdominal aorta and no formation of thrombosis or intimal hyperplasia was observed up to 3 month post implantation.
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