Biomaterial-driven in situ cardiovascular tissue engineering : a multi-disciplinary perspective
TLDR
The main current challenges for in situ cardiovascular regeneration are pinpointed and further address, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.Abstract:
There is a persistent and growing clinical need for readily-available substitutes for heart valves and small-diameter blood vessels. In situ tissue engineering is emerging as a disruptive new technology, providing ready-to-use biodegradable, cell-free constructs which are designed to induce regeneration upon implantation, directly in the functional site. The induced regenerative process hinges around the host response to the implanted biomaterial and the interplay between immune cells, stem/progenitor cell and tissue cells in the microenvironment provided by the scaffold in the hemodynamic environment. Recapitulating the complex tissue microstructure and function of cardiovascular tissues is a highly challenging target. Therein the scaffold plays an instructive role, providing the microenvironment that attracts and harbors host cells, modulating the inflammatory response, and acting as a temporal roadmap for new tissue to be formed. Moreover, the biomechanical loads imposed by the hemodynamic environment play a pivotal role. Here, we provide a multidisciplinary view on in situ cardiovascular tissue engineering using synthetic scaffolds; starting from the state-of-the art, the principles of the biomaterial-driven host response and wound healing and the cellular players involved, toward the impact of the biomechanical, physical, and biochemical microenvironmental cues that are given by the scaffold design. To conclude, we pinpoint and further address the main current challenges for in situ cardiovascular regeneration, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.read more
Citations
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Donor Heterogeneity in the Human Macrophage Response to a Biomaterial under Hyperglycemia in vitro.
Suzanne E Koch,Franka L P Verhaegh,Simone Smink,Silvia M. Mihaila,Carlijn V. C. Bouten,Anthal I.P.M. Smits +5 more
TL;DR: The findings show that the hyperglycemic and hyperosmotic conditions may indeed influence the process of macrophage-driven in situ tissue engineering, and that the extent of this is likely to be patient-specific.
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Properties and Printability of the Synthesized Hydrogel Based on GelMA
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TL;DR: Gelatin methacryloyl (GelMA) has recently attracted increasing attention as mentioned in this paper , allowing for the adjustment of the mechanical properties using such factors as degree of functionalization, concentration, and photocrosslinking parameters.
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Tissue Engineering Concept
TL;DR: In this paper , the authors introduce the primary elements associated with tissue engineering along with their functionalities and bring together the various concepts in tissue engineering that offer significant potential for the generation of functional tissues and organs.
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