Journal ArticleDOI
Biophysical processes underlying cross-seeding in amyloid aggregation and implications in amyloid pathology.
TLDR
This review article focuses on the biophysical processes underlying the cross-seeding for some of the most commonly studied amyloid proteins, including hIAPP, human islet amyloids polypeptide (hIAPP), and alpha-synuclein.About:
This article is published in Biophysical Chemistry.The article was published on 2021-02-01. It has received 95 citations till now. The article focuses on the topics: Amyloid & Amylin.read more
Citations
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Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes
Danilo Milardi,Ehud Gazit,Sheena E. Radford,Yong Xu,Rodrigo Gallardo,Amedeo Caflisch,Gunilla T. Westermark,Per Westermark,Carmelo La Rosa,Ayyalusamy Ramamoorthy +9 more
TL;DR: A review of the current knowledge of the structures and pathology associated with hIAPP self-assembly and point out the opportunities for therapy that a detailed biochemical, biophysical, and cellular understanding of its aggregation may unveil.
Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease
Jay Rasmussen,Jay Rasmussen,Jasmin Mahler,Natalie Beschorner,Stephan A. Kaeser,Stephan A. Kaeser,Lisa M. Häsler,Lisa M. Häsler,Frank Baumann,Frank Baumann,Sofie Nyström,Erik Portelius,Erik Portelius,Kaj Blennow,Kaj Blennow,Tammaryn Lashley,Nick C. Fox,Diego Sepulveda-Falla,Diego Sepulveda-Falla,Markus Glatzel,Adrian L. Oblak,Bernardino Ghetti,K. Peter R. Nilsson,Per Hammarström,Matthias Staufenbiel,Lary C. Walker,Mathias Jucker,Mathias Jucker +27 more
TL;DR: In this paper, the spectral properties of conjugated oligothiophenes (LCO) were analyzed for β-amyloid plaques in postmortem tissue sections from frontal, temporal, and occipital neocortices in 40 cases of familial Alzheimer's disease (AD) or sporadic (idiopathic) AD (sAD).
Journal ArticleDOI
Kinetics theories to understand the mechanism of aggregation of a protein and to design strategies for its inhibition.
TL;DR: In this article, the authors focus on the contribution of molecular events to protein aggregation based on the analysis of kinetic profiles of aggregation and discuss the effect of inhibitors which target various species of aggregation pathways on the kinetic profile of protein aggregation.
Journal ArticleDOI
Antimicrobial α-defensins as multi-target inhibitors against amyloid formation and microbial infection.
TL;DR: In this paper, the authors proposed and demonstrated a new anti-amyloid and antimicrobial hypothesis to discover two host-defense antimicrobial peptides of α-defensins containing β-rich structures.
Journal ArticleDOI
Manganese promotes α-synuclein amyloid aggregation through the induction of protein phase transition
TL;DR: Zhang et al. as discussed by the authors showed that Mn2+ facilitates α-Syn phase transition to accelerate the formation of α-syn amyloid aggregates and provide new insights for targeting αSyn phase separation in PD treatment.
References
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Journal ArticleDOI
Mutation in the α-synuclein gene identified in families with Parkinson's disease
Mihael H. Polymeropoulos,Christian Lavedan,Elisabeth Leroy,Susan E. Ide,Anindya Dehejia,Amalia Dutra,Brian L. Pike,Holly Root,Jeffrey Rubenstein,Rebecca Boyer,Edward S. Stenroos,Settara C. Chandrasekharappa,Aglaia Athanassiadou,Theodore Papapetropoulos,William G. Johnson,Alice Lazzarini,Roger C. Duvoisin,Giuseppe Di Iorio,Lawrence I. Golbe,Robert L. Nussbaum +19 more
TL;DR: A mutation was identified in the α-synuclein gene, which codes for a presynaptic protein thought to be involved in neuronal plasticity, in the Italian kindred and in three unrelated families of Greek origin with autosomal dominant inheritance for the PD phenotype.
Journal ArticleDOI
Parkinson’s disease: clinical features and diagnosis
TL;DR: A thorough understanding of the broad spectrum of clinical manifestations of PD is essential to the proper diagnosis of the disease and genetic mutations or variants, neuroimaging abnormalities and other tests are potential biomarkers that may improve diagnosis and allow the identification of persons at risk.
Journal ArticleDOI
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium
Ian G. McKeith,Ian G. McKeith,Dennis W. Dickson,James Lowe,Murat Emre,John T. O'Brien,Howard Feldman,Jeffrey L. Cummings,John E. Duda,Carol F. Lippa,Elaine K. Perry,Dag Aarsland,Hiroyuki Arai,Clive Ballard,B. F. Boeve,David J. Burn,Durval C. Costa,T. Del Ser,Bruno Dubois,Douglas Galasko,Serge Gauthier,Christopher G. Goetz,Estrella Gómez-Tortosa,Glenda M. Halliday,L. A. Hansen,John Hardy,Takeshi Iwatsubo,Raj N. Kalaria,Daniel I. Kaufer,Rose Anne Kenny,Amos D. Korczyn,Kenji Kosaka,Virginia M.-Y. Lee,Andrew J. Lees,Irene Litvan,Elisabet Londos,Oscar L. Lopez,Satoshi Minoshima,Yoshikuni Mizuno,José Antonio Molina,Elizabeta B. Mukaetova-Ladinska,Florence Pasquier,Robert H. Perry,Jörg B. Schulz,John Q. Trojanowski,Masahito Yamada +45 more
TL;DR: The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them as mentioned in this paper.
Journal ArticleDOI
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.
Rejko Krüger,Wilfried Kuhn,Thomas Müller,Dirk Woitalla,Manuel B. Graeber,Sigfried Kösel,Horst Przuntek,Jörg T. Epplen,Ludger Schöls,Olaf Riess +9 more
Journal ArticleDOI
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies
TL;DR: It is shown thatLewy bodies and Lewy neurites from Parkinson’s disease and dementia with Lewy bodies are stained strongly by antibodies directed against amino- terminal and carboxyl-terminal sequences of α-synuclein, showing the presence of full- length or close to full-length α- synuclein.
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