Journal ArticleDOI
Bioprinting for cancer research
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TLDR
3D cancer models that mimic the tumor microenvironment are discussed, providing a platform for deeper understanding of cancer pathology, anticancer drug screening, and cancer treatment development.About:
This article is published in Trends in Biotechnology.The article was published on 2015-09-01. It has received 271 citations till now.read more
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An overview on 3D printing technology: Technological, materials, and applications
TL;DR: In this paper, the authors present an overview of the types of 3D printing technologies, the application of three-dimensional printing technology and lastly, the materials used for 3-D printing technology in manufacturing industry.
Journal ArticleDOI
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Guoyou Huang,Fei Li,Xin Zhao,Yufei Ma,Yuhui Li,Min Lin,Guorui Jin,Tian Jian Lu,Guy M. Genin,Feng Xu +9 more
TL;DR: This review encapsulates where recent advances appear to leave the ever-shifting state of the art in the cell microenvironment, and it highlights areas in which substantial potential and uncertainty remain.
Journal ArticleDOI
Screening out irrelevant cell-based models of disease
Peter Horvath,Peter Horvath,Nathalie Aulner,Marc Bickle,Anthony Davies,Anthony Davies,Elaine Del Nery,Daniel Ebner,María C. Montoya,Päivi Östling,Päivi Östling,Vilja Pietiäinen,Leo S. Price,Spencer L. Shorte,Gerardo Turcatti,Carina von Schantz,Neil O. Carragher +16 more
TL;DR: In this article, the authors propose a set of principles to facilitate the definition and development of disease-relevant assays, and discuss new opportunities for exploiting the latest advances in cell-based assay technologies in drug discovery.
Journal ArticleDOI
Manufacturing of hydrogel biomaterials with controlled mechanical properties for tissue engineering applications.
Armin Vedadghavami,Farnaz Minooei,Mohammad Hossein Mohammadi,Sultan Khetani,Ahmad Rezaei Kolahchi,Shohreh Mashayekhan,Amir Sanati-Nezhad +6 more
TL;DR: The most common approaches used for tuning mechanical properties of hydrogels including but are not limited to, interpenetrating polymer networks, nanocomposites, self-assembly techniques, and co-polymerization are discussed.
Journal ArticleDOI
Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs.
Nureddin Ashammakhi,Nureddin Ashammakhi,Samad Ahadian,Chun Xu,Chun Xu,H. Montazerian,Hyojin Ko,Rohollah Nasiri,Rohollah Nasiri,Natan Roberto de Barros,Ali Khademhosseini +10 more
TL;DR: This review highlights important advances in heterogeneous bioinks and bioprinting technologies to fabricate biomimetic tissue constructs and opportunities to further accelerate this research area are described.
References
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Journal ArticleDOI
3D bioprinting of tissues and organs
Sean V. Murphy,Anthony Atala +1 more
TL;DR: 3D bioprinting is being applied to regenerative medicine to address the need for tissues and organs suitable for transplantation and developing high-throughput 3D-bioprinted tissue models for research, drug discovery and toxicology.
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Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
Susan K. Hobbs,Wayne L. Monsky,Fan Yuan,W. G. Roberts,Linda G. Griffith,Vladimir P. Torchilin,Rakesh K. Jain +6 more
TL;DR: Delivery may be less efficient in cranial tumors than in subcutaneous tumors, delivery may be reduced during tumor regression induced by hormonal ablation, and permeability to a molecule is independent of pore cutoff size as long as the diameter of the molecule is much less than the pore diameter.
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Monodisperse Double Emulsions Generated from a Microcapillary Device
Andrew S. Utada,Elise Lorenceau,Darren R. Link,Peter D. Kaplan,Howard A. Stone,David A. Weitz +5 more
TL;DR: It is shown that the droplet size can be quantitatively predicted from the flow profiles of the fluids, which makes this a flexible and promising technique.
Journal ArticleDOI
Influence of tumour micro-environment heterogeneity on therapeutic response
TL;DR: The dynamic tumour topography varies drastically even throughout the same lesion, so evaluating tumours as complete organs, and not simply as masses of transformed epithelial cells, becomes paramount.