BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting.
Noa Dagan,Noam Barda,Noam Barda,Noam Barda,Eldad Kepten,Oren Miron,Oren Miron,Shay Perchik,Mark A. Katz,Mark A. Katz,Mark A. Katz,Miguel A. Hernán,Marc Lipsitch,Ben Y. Reis,Ran D. Balicer,Ran D. Balicer +15 more
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TLDR
This study in a nationwide mass vaccination setting suggests that the BNT162b2 mRNA vaccine is effective for a wide range of Covid-19–related outcomes, a finding consistent with that of the randomized trial.Abstract:
Background As mass vaccination campaigns against coronavirus disease 2019 (Covid-19) commence worldwide, vaccine effectiveness needs to be assessed for a range of outcomes across diverse p...read more
Citations
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Journal ArticleDOI
Effect of Covid-19 Vaccination on Transmission of Alpha and Delta Variants
David W Eyre,D. Taylor,M. B. Purver,D. Chapman,Tom Fowler,Koen B. Pouwels,A. Sarah Walker,Tim E. A. Peto +7 more
TL;DR: Vaccination was associated with a smaller reduction in transmission of the delta variant than of the alpha variant, and the effects of vaccination decreased over time, similar to those in unvaccinated persons by 12 weeks in index patients who had received ChAdOx1 nCoV-19 and attenuating substantially in those who hadreceived BNT162b2.
Journal ArticleDOI
Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection.
Martina Patone,Lahiru Handunnetthi,Defne Saatci,Jiafeng Pan,Srinivasa Vittal Katikireddi,Saif Razvi,David M. Hunt,Xue W Mei,Sharon Dixon,Francesco Zaccardi,Kamlesh Khunti,Peter J. Watkinson,Carol Coupland,Carol Coupland,James Doidge,David A Harrison,Rommel Ravanan,Aziz Sheikh,Aziz Sheikh,Chris Robertson,Julia Hippisley-Cox +20 more
TL;DR: In this article, a self-controlled case series study was conducted to investigate hospital admissions from neurological complications in the 28 days after a first dose of ChAdOx1nCoV-19 (n = 20,417,752) or BNT162b2 (n= 12,134,782), and after a SARS-coV-2-positive test.
Journal ArticleDOI
Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients.
Hector Rincon-Arevalo,Mira Choi,Ana Luisa Stefanski,Fabian Halleck,Ulrike Weber,Franziska Szelinski,Bernd Jahrsdörfer,Hubert Schrezenmeier,Carolin Ludwig,Arne Sattler,Katja Kotsch,Alexander Potekhin,Yidan Chen,Gerd R Burmester,Kai-Uwe Eckardt,Gabriela Maria Guerra,Pawel Durek,Frederik Heinrich,Marta Ferreira-Gomes,Andreas Radbruch,Klemens Budde,Andreia C. Lino,Mir-Farzin Mashreghi,Mir-Farzin Mashreghi,Eva Schrezenmeier,Thomas Dörner +25 more
TL;DR: In this article, the authors found that immunosuppression resulted in impaired protective immunity after mRNA vaccination, including Ig induction with corresponding generation of plasmablasts and memory B cells.
Journal ArticleDOI
Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine-breakthrough infections: a multi-center cohort study
Po Ying Chia,Po Ying Chia,Sean Wei Xiang Ong,Calvin J Chiew,Li Wei Ang,Jean-Marc Chavatte,Tze Minn Mak,Lin Cui,Shirin Kalimuddin,Shirin Kalimuddin,Wan Ni Chia,Chee Wah Tan,Louis Y.A. Chai,Louis Y.A. Chai,Seow Yen Tan,Shuwei Zheng,Raymond T. P. Lin,Lin-Fa Wang,Yee Sin Leo,Vernon J. Lee,David C. Lye,Barnaby Edward Young,Barnaby Edward Young +22 more
TL;DR: In this article, the authors conducted a multi-centre retrospective cohort study of patients in Singapore who had received a licensed mRNA vaccine and been admitted to hospital with B.1.2 infection.
Journal ArticleDOI
Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients.
Arne Sattler,Eva Schrezenmeier,Ulrike Weber,Alexander Potekhin,Friederike Bachmann,Henriette Straub-Hohenbleicher,Klemens Budde,Elena Storz,Vanessa Proß,Yasmin Bergmann,Linda Marie Laura Thole,Caroline Tizian,Oliver Hölsken,Oliver Hölsken,Andreas Diefenbach,Hubert Schrezenmeier,Bernd Jahrsdörfer,Tomasz Zemojtel,Katharina Jechow,Christian Conrad,Sören Lukassen,Diana Stauch,Nils Lachmann,Mira Choi,Fabian Halleck,Katja Kotsch +25 more
TL;DR: In this paper, the authors comprehensively analyzed humoral and cellular responses in kidney transplant recipients after the standard second vaccination dose and found that spike-specific CD8+ T helper cell responses were less abundant than their CD4+ counterparts in healthy controls and hemodialysis patients and almost undetectable in transplant patients.
References
More filters
Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal ArticleDOI
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
Journal ArticleDOI
Validation of a combined comorbidity index.
Mary E. Charlson,Ted P. Szatrowski,Ted P. Szatrowski,Janey C. Peterson,Janey C. Peterson,Jeffrey P. Gold +5 more
TL;DR: The estimated relative risk of death from an increase of one in the comorbidity score proved approximately equal to that from an additional decade of age.
Journal ArticleDOI
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Lindsey R. Baden,Hana M. El Sahly,Brandon Essink,Karen L. Kotloff,Sharon E. Frey,Rick Novak,David Diemert,Stephen A. Spector,Nadine Rouphael,C. Buddy Creech,John W McGettigan,Shishir Khetan,Nathan Segall,Joel Solis,Adam Brosz,Carlos Fierro,Howard J. Schwartz,Kathleen M. Neuzil,Lawrence Corey,Peter B. Gilbert,Holly Janes,Dean Follmann,Mary A. Marovich,John R. Mascola,Laura Polakowski,Julie E. Ledgerwood,Barney S. Graham,Hamilton Bennett,Rolando Pajon,Conor Knightly,Brett Leav,Weiping Deng,Honghong Zhou,Shu Liang Han,Melanie Ivarsson,Jacqueline Miller,Tal Z Zaks +36 more
TL;DR: The mRNA-1273 vaccine as discussed by the authors is a lipid nanoparticle-encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19.
Journal ArticleDOI
Using Big Data to Emulate a Target Trial When a Randomized Trial Is Not Available
Miguel A. Hernán,James M. Robins +1 more
TL;DR: This work outlines a framework for comparative effectiveness research using big data that makes the target trial explicit and channels counterfactual theory for comparing the effects of sustained treatment strategies, organizes analytic approaches, provides a structured process for the criticism of observational studies, and helps avoid common methodologic pitfalls.
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