BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting.
Noa Dagan,Noam Barda,Noam Barda,Noam Barda,Eldad Kepten,Oren Miron,Oren Miron,Shay Perchik,Mark A. Katz,Mark A. Katz,Mark A. Katz,Miguel A. Hernán,Marc Lipsitch,Ben Y. Reis,Ran D. Balicer,Ran D. Balicer +15 more
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TLDR
This study in a nationwide mass vaccination setting suggests that the BNT162b2 mRNA vaccine is effective for a wide range of Covid-19–related outcomes, a finding consistent with that of the randomized trial.Abstract:
Background As mass vaccination campaigns against coronavirus disease 2019 (Covid-19) commence worldwide, vaccine effectiveness needs to be assessed for a range of outcomes across diverse p...read more
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Journal ArticleDOI
COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study.
Victoria Hall,Victoria Hall,Sarah Foulkes,Ayoub Saei,Nick Andrews,Nick Andrews,Blanche Oguti,Blanche Oguti,Andre Charlett,Andre Charlett,Andre Charlett,Edgar Wellington,Julia Stowe,Natalie Gillson,Ana Atti,Jasmin Islam,Ioannis Karagiannis,Katie Munro,Jameel Khawam,Meera Chand,Colin S Brown,Mary Ramsay,Mary Ramsay,Jamie Lopez-Bernal,Susan Hopkins,Susan Hopkins,N Andrews,A Atti,H Aziz,Tim Brooks,CS Brown,D Camero,C Carr,MA Chand,A Charlett,Hayley Crawford,Michael J. Cole,J Conneely,Silvia D'Arcangelo,Joanna Ellis,S Evans,S Foulkes,N Gillson,Robin Gopal,L Hall,V J Hall,P Harrington,Susan R. Hopkins,Jacqueline Hewson,Katja Hoschler,D Ironmonger,J Islam,Meaghan Kall,I Karagiannis,O Kay,J Khawam,E King,Peter Kirwan,R Kyffin,Angie Lackenby,M Lattimore,Ezra Linley,J Lopez-Bernal,L Mabey,Reuben McGregor,Shahjahan Miah,Ejm Monk,K Munro,Z Naheed,A Nissr,A M O'Connell,B Oguti,Henrietta U. Okafor,S Organ,J Osbourne,Ashley Otter,Minal Patel,Steven Platt,D Pople,K Potts,M Ramsay,Julie V. Robotham,Sakib Rokadiya,Cathy Rowe,A Saei,G Sebbage,Amanda Semper,Madhumita Shrotri,Ruth Simmons,Alex Soriano,P Staves,S Taylor,Arthur Taylor,A Tengbe,S Tonge,Amoolya Vusirikala,Sarah Wallace,E Wellington,Maria Zambon,D Corrigan,M Sartaj,L Cromey,Sharon Campbell,K Braithwaite,L Price,L Haahr,S Stewart,ED Lacey,Linda Partridge,Gretchen A Stevens,Y Ellis,H Hodgson,C Norman,B Larru,S Mcwilliam,A Roynon,J Northfield,Stephen Winchester,P Cieciwa,Aditi Pai,P Bakker,C Loughrey,A Watt,F Adair,Adrian Hawkins,Alastair Grant,R Temple-Purcell,J Howard,N Slawson,C Subudhi,Shân Davies,A Bexley,R Penn,N Wong,G Boyd,A Rajgopal,A Arenas-Pinto,R Matthews,A Whileman,R Laugharne,J Ledger,Trevor J. Barnes,Chris Jones,N Osuji,N Chitalia,T Bailey,S Akhtar,G Harrison,S Horne,Naomi F. Walker,Ken Agwuh,V Maxwell,J Graves,Stephen R. Williams,A O'Kelly,P Ridley,A Cowley,H Johnstone,P Swift,Jane Democratis,Manjula Meda,S Brake,J Gunn,A Selassi,S Hams,V Irvine,Badrinathan Chandrasekaran,C Forsyth,J Radmore,C Thomas,Kevin K. Brown,Stuart K. Roberts,P Burns,K Gajee,T Lewis,T M Byrne,F Sanderson,Stephen R Knight,Emily MacNaughton,Bjl Burton,Helen V. Smith,R Chaudhuri,J Aeron-Thomas,K Hollinshead,R.J. Shorten,A Swan,C Favager,J Murira,S Baillon,S Hamer,Aarti Shah,J Russell,D Brennan,A Dave,Ajay Chawla,F Westwell,D Adeboyeku,Padmasayee Papineni,C Pegg,Martin S. Williams,Shazaad Ahmad,Alex Horsley,Christian Gabriel,K Pagget,G Maloney,J Ashcroft,I Del Rosario,R Crosby-Nwaobi,D Flanagan,D Dhasmana,Stephen J. Fowler,E Cameron,L Prentice,C Sinclair,V Bateman,K McLelland-Brooks,A Ho,Michael P. Murphy,A Cochrane,A Gibson,K. Black,K Tempeton,Stacey Donaldson,L Coke,N Elumogo,J Elliott,Debra Padgett,A Cross,Mariyam Mirfenderesky,S Joyce,I Sinanovic,M Howard,P Cowling,M Brazil,E Hanna,A Abdelrazik,S Brand,EA Sheridan,B Wadams,A Lloyd,J Mouland,J Giles,G Pottinger,H Coles,Mark Joseph,M Lee,S Orr,H Chenoweth,D Browne,Cressida Auckland,R Lear,Tabitha Mahungu,Alison Rodger,Simon Warren,D Brooking,S Pai,R Druyeh,Edward M. Smith,S. Stone,Sarah Meisner,D Delgado,E Underhill,L Keen,M Aga,P Domingos,S Gormley,Caroline Kerrison,S Birch,T DeSilva,L Allsop,S Ambalkar,M Beekes,S Jose,J Tomlinson,Sharen Painter,Claire Price,Justin Pepperell,Keith D. James,T Trinick,L Moore,Jeremy N. Day,A Boulos,I Knox,E Defever,D McCracken,K Gray,A Houston,Tim Planche,R Pritchard Jones,Diane Wycherley,Sara Bennett,J Marrs,K Nimako,Benjamin J. Stewart,SC Bain,N Kalakonda,S Khanduri,A Ashby,Matthew T. G. Holden,N Mahabir,J Harwood,Brendan A I Payne,K Court,Nicholas J. White,R Longfellow,L E Hughes,M E Green,M Halkes,P Mercer,A Roebuck,Eleri Wilson-Davies,L Gallego,Rajeka Lazarus,N Aldridge,Louise Berry,Frances L. Game,Timothy M Reynolds,Christopher W Holmes,Martin Wiselka,A Higham,M Booth,C Duff,J Alderton,D Hilton,J Powell,Alan Jackson,AJ Plant,Nada Ahmed,T Chin,M Z Qazzafi,A M Moody,Robert Tilley,T Donaghy,M O'Kane,K Shipman,R Sierra,Chetan Parmar,Gordon B. Mills,Daniel Harvey,Ywj Huang,J Birch,Louise Robinson,S Board,A Broadley,C Laven,N Todd,David W Eyre,Katie Jeffery,Susanna Dunachie,Christopher J A Duncan,Paul Klenerman,Lance Turtle,Helen Baxendale,Jonathan L. Heeney +353 more
TL;DR: The SIREN study as discussed by the authors showed that the BNT162b2 vaccine can prevent both symptomatic and asymptomatic infection in working-age adults in the UK.
Journal ArticleDOI
Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile.
Alejandro Jara,Eduardo A. Undurraga,Cecilia González,Fabio Paredes,Tomás Fontecilla,Gonzalo Jara,Alejandra Pizarro,Johanna Acevedo,Katherinne Leo,Francisco Javier León,Carlos Sans,Paulina Leighton,Pamela Suárez,Heriberto García-Escorza,Rafael Araos +14 more
TL;DR: In this article, estimates of vaccine effectiveness are urgently needed to support mass vaccination campaigns to prevent coronavirus disease 2019 (Covid-19) are occurring in many countries.
Journal ArticleDOI
Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents.
Robert W. Frenck,Nicola P. Klein,Nicholas Kitchin,Alejandra Gurtman,Judith Absalon,Stephen Lockhart,John L. Perez,Emmanuel B. Walter,Shelly Senders,Ruth Bailey,Kena A. Swanson,Hua Ma,Xia Xu,Kenneth Koury,Warren Kalina,David K. C. Cooper,Timothy Jennings,Donald M Brandon,Stephen J. Thomas,Özlem Türeci,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +25 more
TL;DR: The vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had not been authorized for emergency use in persons younger than 16 years of.
Journal ArticleDOI
Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study.
Anika Singanayagam,Anika Singanayagam,Anika Singanayagam,Seran Hakki,Jake Dunning,Jake Dunning,Kieran J Madon,Michael A. Crone,Aleksandra Koycheva,Nieves Derqui-Fernandez,Jack L Barnett,Michael G Whitfield,Robert Varro,Andre Charlett,Rhia Kundu,Joe Fenn,Jessica Cutajar,Valerie Quinn,Emily Conibear,Wendy S. Barclay,Paul S. Freemont,Graham P. Taylor,Shazaad Ahmad,Maria Zambon,Neil M. Ferguson,Ajit Lalvani,Anjna Badhan,Simon Dustan,Chitra Tejpal,Anjeli V Ketkar,J. S. Narean,Sarah Hammett,Eimear McDermott,Timesh D Pillay,Hamish Houston,Constanta Luca,Jada Samuel,Samuel Bremang,Samuel Evetts,John Poh,Charlotte Anderson,David C. Jackson,Shahjahan Miah,Joanna Ellis,Angie Lackenby +44 more
TL;DR: In this article, the authors investigated transmission and viral load kinetics in vaccinated and unvaccinated individuals with mild delta variant infection in the community, and found that faster viral load growth was correlated with higher peak viral load (correlation 0·42 [95% credible interval 0·13 to 0·65]) and slower decline (0·44 [−0·67 to −0·18]).
Journal ArticleDOI
SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses.
Jackson S. Turner,Jane A. O’Halloran,Elizaveta Kalaidina,Wooseob Kim,Aaron J. Schmitz,Julian Q. Zhou,Tingting Lei,Mahima Thapa,Rita E. Chen,James Brett Case,Fatima Amanat,Adriana M Rauseo,Alem Haile,Xuping Xie,Michael K. Klebert,Teresa Suessen,William D. Middleton,Pei Yong Shi,Florian Krammer,Sharlene A. Teefey,Michael S. Diamond,Rachel M. Presti,Ali H. Ellebedy +22 more
TL;DR: In this article, the authors examined antigen-specific B-cell responses in peripheral blood and draining lymph nodes in 14 individuals who had received 2-doses of BNT162b2, an mRNA-based vaccine that encodes the full-length SARS-CoV-2 spike (S) gene1.
References
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