Journal ArticleDOI
Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies.
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High levels of cardiomyocyte death occur for at least 4 days after grafting into injured hearts, in large part due to ischemia.About:
This article is published in Journal of Molecular and Cellular Cardiology.The article was published on 2001-05-01. It has received 873 citations till now. The article focuses on the topics: Cellular cardiomyoplasty & Necrosis.read more
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Myoblast transplantation for heart failure: where are we heading?
Ottavio Alfieri,Ugolino Livi,Luigi Martinelli,Giorgio Arpesella,Carlo Valfrè,Elisabetta Lapenna,Michel Desnos,Albert Hagège,Philippe Menasché +8 more
TL;DR: Neither skeletal myoblasts nor bone marrow cells fulfill the major criteria required for a true cardiac regeneration: a coupling of the grafted cells with those of the recipient myocardium and the subsequent generation of a contractile force.
Microfluidics-Assisted Fabrication of Gelatin-Silica Core–Shell Microgels for Injectable Tissue Constructs
Chaenyung Cha,Jonghyun Oh,Keekyoung Kim,Yiling Qiu,Maria Joh,Su Ryon Shin,Su Ryon Shin,Xin-Xin Wang,Gulden Camci-Unal,Kai-Tak Wan,Ronglih Liao,Ali Khademhosseini,Ali Khademhosseini +12 more
TL;DR: Overall, the microfluidic approach to generate cell-adhesive microgel core, coupled with silica hydrogels as a protective shell, will be highly useful as a cell culture platform to generate a wide range of injectable tissue constructs.
Journal ArticleDOI
Decreased expression of c-kit and telomerase in a rat model of chronic endometrial ischemia.
Jianguo Hu,Rui Yuan +1 more
TL;DR: The present work shows that chronic ischemia and chronic endometrial ischemIA-associated stem/progenitor cells apoptosis may be responsible for the pathogenesis of thin endometrium.
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Protective Effect of S-Adenosyl-L-Methionine on Oxidative Stress-Induced Apoptosis Regulates Nrf2 via IGF-I in Rat Bone Marrow Mesenchymal Stem Cells
TL;DR: The results suggest that the cytoprotective effect of SAM against H2O2- induced apoptosis is mediated by increased Nrf2 activity through IGF-I, which could regulate the metabolic fate and survival of MSCs.
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Stem cell therapy for acute myocardial infarction - focusing on the comparison between Muse cells and mesenchymal stem cells
TL;DR: In this paper , the authors described stem cell therapies using conventional BM-MNCs and BM-MSCs, and Muse cells which have potential for clinical use for the treatment of acute myocardial infarction (AMI).
References
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Journal ArticleDOI
Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
Journal ArticleDOI
Cellular survival: a play in three Akts
TL;DR: The mechanisms by which survival factors regulate the PI3K/c-Akt cascade, the evidence that activation of the PI 3K/ c-AKT pathway promotes cell survival, and the current spectrum of c- akt targets and their roles in mediating c- Akt-dependent cell survival are reviewed.
Journal Article
Apoptosis, oncosis, and necrosis : an overview of cell death
Guido Majno,Isabelle Joris +1 more
TL;DR: Some of the typical features of apoptosis are discussed, such as budding (as opposed to blebbing and zeiosis) and the inflammatory response, and stands in contrast to apoptosis, which leads to necrosis with karyorhexis and cell shrinkage.
Journal ArticleDOI
Derivation of pluripotent stem cells from cultured human primordial germ cells
Michael J. Shamblott,Joyce Axelman,Shunping Wang,Elizabeth M. Bugg,John W. Littlefield,Peter J. Donovan,Paul D. Blumenthal,George R. Huggins,John D. Gearhart +8 more
TL;DR: In this article, a set of primordial germ cells (PGCs, 5-9 weeks postfertilization) were cultured on mouse STO fibroblast feeder layers in the presence of human recombinant leukemia inhibitory factor (HILI) and forskolin.
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Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts.
TL;DR: A simple genetic manipulation can be used to select essentially pure cultures of cardiomyocytes from differentiating ES cells that are suitable for the formation of intracardiac grafts, and should be applicable to all ES-derived cell lineages.