Journal ArticleDOI
Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies.
Reads0
Chats0
TLDR
High levels of cardiomyocyte death occur for at least 4 days after grafting into injured hearts, in large part due to ischemia.About:
This article is published in Journal of Molecular and Cellular Cardiology.The article was published on 2001-05-01. It has received 873 citations till now. The article focuses on the topics: Cellular cardiomyoplasty & Necrosis.read more
Citations
More filters
Journal ArticleDOI
Transplantation of human embryonic stem cell-derived endothelial cells for vascular diseases.
TL;DR: This review will focus on the differentiation pathways of hESCs and their therapeutic potential for vascular diseases, as well as the monitoring of transplanted cells' fate via molecular imaging.
Journal ArticleDOI
Human Embryonic Stem Cells and Cardiac Repair
TL;DR: The phenotype of hESC-derived cardiomyocytes and preclinical experience with these cells are described and the need for preparations of high cardiac purity, improved methods of delivery, and approaches to overcome immune rejection and other causes of graft cell death are considered.
Journal ArticleDOI
Contractile force generation by 3D hiPSC-derived cardiac tissues is enhanced by rapid establishment of cellular interconnection in matrix with muscle-mimicking stiffness.
Soah Lee,Vahid Serpooshan,Xinming Tong,Sneha Venkatraman,Meelim Lee,Jae Cheol Lee,Orlando Chirikian,Joseph C. Wu,Sean M. Wu,Fan Yang +9 more
TL;DR: Human cardiac microtissues encapsulating human induced pluripotent stem cell-derived cardiomyocytes in chemically-crosslinked gelatin hydrogels with tunable stiffness and degradation demonstrate that muscle-mimicking stiffness together with robust cellular interconnection contributes to enhancement in sarcomeric organization and contractile function of the engineered cardiac tissue.
Journal ArticleDOI
Molecular imaging of cardiovascular gene products.
TL;DR: The basic science of gene therapy will be reviewed first, followed by application in clinical cardiology and concluding with other applications for molecular imaging.
Journal ArticleDOI
Long-term outcome of fetal cell transplantation on postinfarction ventricular remodeling and function
Mu Yao,Thomas Dieterle,Sharon L. Hale,Joan Dow,Laurence H. Kedes,Kirk L. Peterson,Robert A. Kloner,Robert A. Kloner +7 more
TL;DR: F fetal cell-transplant therapy mitigated the longer-term adverse effects of LV remodeling following a myocardial infarction, and improved LV ejection fraction over the course of 10 months.
References
More filters
Journal ArticleDOI
Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
Journal ArticleDOI
Cellular survival: a play in three Akts
TL;DR: The mechanisms by which survival factors regulate the PI3K/c-Akt cascade, the evidence that activation of the PI 3K/ c-AKT pathway promotes cell survival, and the current spectrum of c- akt targets and their roles in mediating c- Akt-dependent cell survival are reviewed.
Journal Article
Apoptosis, oncosis, and necrosis : an overview of cell death
Guido Majno,Isabelle Joris +1 more
TL;DR: Some of the typical features of apoptosis are discussed, such as budding (as opposed to blebbing and zeiosis) and the inflammatory response, and stands in contrast to apoptosis, which leads to necrosis with karyorhexis and cell shrinkage.
Journal ArticleDOI
Derivation of pluripotent stem cells from cultured human primordial germ cells
Michael J. Shamblott,Joyce Axelman,Shunping Wang,Elizabeth M. Bugg,John W. Littlefield,Peter J. Donovan,Paul D. Blumenthal,George R. Huggins,John D. Gearhart +8 more
TL;DR: In this article, a set of primordial germ cells (PGCs, 5-9 weeks postfertilization) were cultured on mouse STO fibroblast feeder layers in the presence of human recombinant leukemia inhibitory factor (HILI) and forskolin.
Journal ArticleDOI
Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts.
TL;DR: A simple genetic manipulation can be used to select essentially pure cultures of cardiomyocytes from differentiating ES cells that are suitable for the formation of intracardiac grafts, and should be applicable to all ES-derived cell lineages.