Journal ArticleDOI
Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies.
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High levels of cardiomyocyte death occur for at least 4 days after grafting into injured hearts, in large part due to ischemia.About:
This article is published in Journal of Molecular and Cellular Cardiology.The article was published on 2001-05-01. It has received 873 citations till now. The article focuses on the topics: Cellular cardiomyoplasty & Necrosis.read more
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Heat shock pretreatment improves mesenchymal stem cell viability by heat shock proteins and autophagy to prevent cisplatin-induced granulosa cell apoptosis.
TL;DR: HSP can alleviate the apoptosis and improve the survival of BMSCs under chemotherapy environment and the mechanism may be associated with the elevated expression of HSP70 and HSP90 and the attenuation of autophagy.
Journal ArticleDOI
Direct Cardiac Reprogramming: A Novel Approach for Heart Regeneration
TL;DR: Through direct cardiac reprogramming, new cardiomyocytes can be generated and scar tissue reduced to restore cardiac function, and, thus, direct cardiacReprogramming may serve as a powerful strategy for cardiac regeneration.
Journal ArticleDOI
A chemical biology approach to myocardial regeneration.
Erik Willems,Marion Lanier,Elvira Forte,Frederick Lo,Frederick Lo,John R. Cashman,Mark Mercola +6 more
TL;DR: The extracellular factors that control stem cell cardiomyogenesis are reviewed and new approaches that combine embryology with stem cell biology to discover drug-like small molecules that stimulate cardiogenesis and potentially contribute to the development of pharmaceutical strategies for heart muscle regeneration are described.
Journal ArticleDOI
Transplantation of Sendai viral angiopoietin-1-modified mesenchymal stem cells for ischemic limb disease.
Wenhua Piao,Huishan Wang,Makoto Inoue,Mamoru Hasegawa,Hirofumi Hamada,Jianhua Huang,Jianhua Huang +6 more
TL;DR: SeVhAng-1 modification enhanced angiogenetic effect of MSCs by both angiogenesis and cell protection, and may serve as a more effective tool in dealing with ischemic limb disease.
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Cardiac Tissues From Stem Cells: New Routes to Maturation and Cardiac Regeneration.
Giulia Campostrini,Laura M. Windt,Berend J. van Meer,Berend J. van Meer,Milena Bellin,Milena Bellin,Christine L. Mummery,Christine L. Mummery +7 more
TL;DR: The ability of human pluripotent stem cells to form all cells of the body has provided many opportunities to study disease and produce cells that can be used for therapy in regenerative medicine as discussed by the authors.
References
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Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
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Cellular survival: a play in three Akts
TL;DR: The mechanisms by which survival factors regulate the PI3K/c-Akt cascade, the evidence that activation of the PI 3K/ c-AKT pathway promotes cell survival, and the current spectrum of c- akt targets and their roles in mediating c- Akt-dependent cell survival are reviewed.
Journal Article
Apoptosis, oncosis, and necrosis : an overview of cell death
Guido Majno,Isabelle Joris +1 more
TL;DR: Some of the typical features of apoptosis are discussed, such as budding (as opposed to blebbing and zeiosis) and the inflammatory response, and stands in contrast to apoptosis, which leads to necrosis with karyorhexis and cell shrinkage.
Journal ArticleDOI
Derivation of pluripotent stem cells from cultured human primordial germ cells
Michael J. Shamblott,Joyce Axelman,Shunping Wang,Elizabeth M. Bugg,John W. Littlefield,Peter J. Donovan,Paul D. Blumenthal,George R. Huggins,John D. Gearhart +8 more
TL;DR: In this article, a set of primordial germ cells (PGCs, 5-9 weeks postfertilization) were cultured on mouse STO fibroblast feeder layers in the presence of human recombinant leukemia inhibitory factor (HILI) and forskolin.
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Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts.
TL;DR: A simple genetic manipulation can be used to select essentially pure cultures of cardiomyocytes from differentiating ES cells that are suitable for the formation of intracardiac grafts, and should be applicable to all ES-derived cell lineages.