Journal ArticleDOI
Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies.
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High levels of cardiomyocyte death occur for at least 4 days after grafting into injured hearts, in large part due to ischemia.About:
This article is published in Journal of Molecular and Cellular Cardiology.The article was published on 2001-05-01. It has received 873 citations till now. The article focuses on the topics: Cellular cardiomyoplasty & Necrosis.read more
Citations
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Journal ArticleDOI
Heart Failure Management: The Present and the Future
Mohammad N. Jameel,Jianyi Zhang +1 more
TL;DR: Novel modalities that have been shown in preclinical studies to exert beneficial effects in animal models of severe LV dysfunction and seem to have the potential to make an impact in the clinical practice of heart-failure management are reviewed.
Book ChapterDOI
Clinical trials of cardiac repair with adult bone marrow- derived cells.
TL;DR: Analysis of pooled data suggests that BMC injection enhances left ventricular function, reduces infarct scar size, and improves remodeling in patients with acute MI as well as chronic IHD and BMC therapy also improves clinical outcomes during follow-up without any increase in adverse effects.
Journal ArticleDOI
Overexpression of Csx/Nkx2.5 and GATA-4 enhances the efficacy of mesenchymal stem cell transplantation after myocardial infarction.
TL;DR: Transplantation of MSCs overexpressing Csx/Nkx2.5 and GATA-4 represents a new treatment strategy with the potential to improve cardiac function after myocardial infarction.
Journal ArticleDOI
A methylcellulose and collagen based temperature responsive hydrogel promotes encapsulated stem cell viability and proliferation in vitro
TL;DR: It is demonstrated that human mesenchymal stem cells encapsulated within the gel remained viable and showed raised levels of dsDNA at increasing time points, an indication of cell proliferation.
Journal ArticleDOI
Enhanced potency of cell-based therapy for ischemic tissue repair using an injectable bioactive epitope presenting nanofiber support matrix
Jörn Tongers,Matthew J. Webber,Erin E Vaughan,Eduard Sleep,Marie-Ange Renault,Jerome Roncalli,Ekaterina Klyachko,Tina Thorne,Yang Yu,Katja Theres Marquardt,Katja Theres Marquardt,Christine Kamide,Aiko Ito,Sol Misener,Meredith Millay,Ting Liu,Kentaro Jujo,Gangjian Qin,Douglas W. Losordo,Samuel I. Stupp,Raj Kishore,Raj Kishore +21 more
TL;DR: An injectable, bioactive peptide-based nanofiber matrix that presents an integrin-binding epitope derived from fibronectin improves regenerative efficacy of cell-based strategies in ischemic tissue by enhancing cell survival, retention, and reparative functions.
References
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Journal ArticleDOI
Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
Journal ArticleDOI
Cellular survival: a play in three Akts
TL;DR: The mechanisms by which survival factors regulate the PI3K/c-Akt cascade, the evidence that activation of the PI 3K/ c-AKT pathway promotes cell survival, and the current spectrum of c- akt targets and their roles in mediating c- Akt-dependent cell survival are reviewed.
Journal Article
Apoptosis, oncosis, and necrosis : an overview of cell death
Guido Majno,Isabelle Joris +1 more
TL;DR: Some of the typical features of apoptosis are discussed, such as budding (as opposed to blebbing and zeiosis) and the inflammatory response, and stands in contrast to apoptosis, which leads to necrosis with karyorhexis and cell shrinkage.
Journal ArticleDOI
Derivation of pluripotent stem cells from cultured human primordial germ cells
Michael J. Shamblott,Joyce Axelman,Shunping Wang,Elizabeth M. Bugg,John W. Littlefield,Peter J. Donovan,Paul D. Blumenthal,George R. Huggins,John D. Gearhart +8 more
TL;DR: In this article, a set of primordial germ cells (PGCs, 5-9 weeks postfertilization) were cultured on mouse STO fibroblast feeder layers in the presence of human recombinant leukemia inhibitory factor (HILI) and forskolin.
Journal ArticleDOI
Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts.
TL;DR: A simple genetic manipulation can be used to select essentially pure cultures of cardiomyocytes from differentiating ES cells that are suitable for the formation of intracardiac grafts, and should be applicable to all ES-derived cell lineages.