Journal ArticleDOI
Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies.
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High levels of cardiomyocyte death occur for at least 4 days after grafting into injured hearts, in large part due to ischemia.About:
This article is published in Journal of Molecular and Cellular Cardiology.The article was published on 2001-05-01. It has received 873 citations till now. The article focuses on the topics: Cellular cardiomyoplasty & Necrosis.read more
Citations
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CRISPR/Cas9-Induced Loss of Keap1 Enhances Anti-oxidation in Rat Adipose-Derived Mesenchymal Stem Cells.
TL;DR: It is revealed that loss of Keap1 resulted in anti-oxidative ability in Ad-MSCs, suggesting that the strategy can hopefully increase the viability of mesenchymal stem cells after grafting.
Journal ArticleDOI
Efficient gene transfer of a simian immuno-deficiency viral vector into cardiomyocytes derived from primate embryonic stem cells.
Mihoko Nagata,Masafumi Takahashi,Shin-ichi Muramatsu,Yasuji Ueda,Yutaka Hanazono,Koichi Takeuchi,Koji Okada,Yutaka Suzuki,Yasushi Kondo,Masafumi Suemori,Uichi Ikeda,Imaharu Nakano,Eiji Kobayashi,Mamoru Hasegawa,Keiya Ozawa,Norio Nakatsuji,Kazuyuki Shimada +16 more
TL;DR: Embryonic stem (ES) cells continually proliferate and can generate large numbers of differentiated cells, which offers considerable potential for development research and regenerative cell therapy.
Journal ArticleDOI
Heart regeneration using pluripotent stem cells.
TL;DR: The updated knowledge, perspectives, and limitations of PSC-CMs for heart regeneration are summarized and the recent first clinical trial using human iPSC-C Ms (hiPSCs) is launched in Japan.
Journal ArticleDOI
Cell therapy in congestive heart failure.
Ze-Wei Tao,Long-gui Li +1 more
TL;DR: Treatment of Congestive heart failure by exogenous cell implantation by using potential sources such as BMCs and CSCs to treat animal CHF have shown improved ventricular remodelling and heart function.
Journal ArticleDOI
Engineered heart tissue graft derived from somatic cell nuclear transferred embryonic stem cells improve myocardial performance in infarcted rat heart
Shuanghong Lü,Ying Li,Shaorong Gao,Sheng Liu,Haibin Wang,Wenjun He,Jin Zhou,Zhiqiang Liu,Ye Zhang,Qiuxia Lin,Cumi Duan,Xiangzhong Jerry Yang,Xiangzhong Jerry Yang,Changyong Wang +13 more
TL;DR: Large contractile EHT grafts can be constructed in vitro with the ability to survive after implantation and improve myocardial performance of infarcted rat hearts and NT‐ES cells can be used as a source of seeding cells for cardiac tissue engineering.
References
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Journal ArticleDOI
Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
Journal ArticleDOI
Cellular survival: a play in three Akts
TL;DR: The mechanisms by which survival factors regulate the PI3K/c-Akt cascade, the evidence that activation of the PI 3K/ c-AKT pathway promotes cell survival, and the current spectrum of c- akt targets and their roles in mediating c- Akt-dependent cell survival are reviewed.
Journal Article
Apoptosis, oncosis, and necrosis : an overview of cell death
Guido Majno,Isabelle Joris +1 more
TL;DR: Some of the typical features of apoptosis are discussed, such as budding (as opposed to blebbing and zeiosis) and the inflammatory response, and stands in contrast to apoptosis, which leads to necrosis with karyorhexis and cell shrinkage.
Journal ArticleDOI
Derivation of pluripotent stem cells from cultured human primordial germ cells
Michael J. Shamblott,Joyce Axelman,Shunping Wang,Elizabeth M. Bugg,John W. Littlefield,Peter J. Donovan,Paul D. Blumenthal,George R. Huggins,John D. Gearhart +8 more
TL;DR: In this article, a set of primordial germ cells (PGCs, 5-9 weeks postfertilization) were cultured on mouse STO fibroblast feeder layers in the presence of human recombinant leukemia inhibitory factor (HILI) and forskolin.
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Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts.
TL;DR: A simple genetic manipulation can be used to select essentially pure cultures of cardiomyocytes from differentiating ES cells that are suitable for the formation of intracardiac grafts, and should be applicable to all ES-derived cell lineages.