Journal ArticleDOI
Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies.
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High levels of cardiomyocyte death occur for at least 4 days after grafting into injured hearts, in large part due to ischemia.About:
This article is published in Journal of Molecular and Cellular Cardiology.The article was published on 2001-05-01. It has received 873 citations till now. The article focuses on the topics: Cellular cardiomyoplasty & Necrosis.read more
Citations
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Enhancing stem cell survival in vivo for tissue repair.
Jeong S. Hyun,Misha C. Tran,Victor W. Wong,Victor W. Wong,Michael T. Chung,David Lo,David Lo,Daniel T. Montoro,Derrick C. Wan,Michael T. Longaker +9 more
TL;DR: This review focuses on current advances and techniques being used to increase in vivo stem cell survival for the purpose of tissue regeneration.
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Myocardial regeneration: present and future trends.
TL;DR: Current data derived from animal models suggest that it may be possible to treat heart failure by inserting genetic materials or myogenic cells into injured myocardium, and this exciting research still faces significant difficulties before it can develop into a clinical therapeutic tool.
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Grafting an acellular 3-dimensional collagen scaffold onto a non-transmural infarcted myocardium induces neo-angiogenesis and reduces cardiac remodeling.
Mohamed A. Gaballa,Julia N.E. Sunkomat,Hoang Thai,Hoang Thai,Eugene Morkin,Gordon A. Ewy,Steven Goldman,Steven Goldman +7 more
TL;DR: A 3D collagen type 1 scaffold grafted onto an injured myocardium induced neo-vessel formation and reduced LV remodeling in rats.
Journal ArticleDOI
The evolving role of haematopoietic cell transplantation in radiation injury: potentials and limitations
N Dainiak,R C Ricks +1 more
TL;DR: A review of radiation incident registries indicates that, during this time, 31 patients have undergone transplantation with stem cells from the bone marrow, peripheral blood, cord blood or fetal liver, and 27 patients have expired and the remaining 4 patients have survived with a rejected allograft.
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Combinatorial Polymer Electrospun Matrices Promote Physiologically-Relevant Cardiomyogenic Stem Cell Differentiation
Mukesh Kumar Gupta,Joel M. Walthall,Raghav Venkataraman,Spencer W. Crowder,Dae Kwang Jung,Shann S. Yu,Tromondae K. Feaster,Xintong Wang,Todd D. Giorgio,Charles C. Hong,Franz J. Baudenbacher,Antonis K. Hatzopoulos,Hak-Joon Sung +12 more
TL;DR: Data indicate that ESC-derived cardiomyocyte differentiation and maturation can be promoted by tuning the mechanical and chemical properties of polymer scaffold via copolymerization and electrospinning techniques.
References
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Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
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Cellular survival: a play in three Akts
TL;DR: The mechanisms by which survival factors regulate the PI3K/c-Akt cascade, the evidence that activation of the PI 3K/ c-AKT pathway promotes cell survival, and the current spectrum of c- akt targets and their roles in mediating c- Akt-dependent cell survival are reviewed.
Journal Article
Apoptosis, oncosis, and necrosis : an overview of cell death
Guido Majno,Isabelle Joris +1 more
TL;DR: Some of the typical features of apoptosis are discussed, such as budding (as opposed to blebbing and zeiosis) and the inflammatory response, and stands in contrast to apoptosis, which leads to necrosis with karyorhexis and cell shrinkage.
Journal ArticleDOI
Derivation of pluripotent stem cells from cultured human primordial germ cells
Michael J. Shamblott,Joyce Axelman,Shunping Wang,Elizabeth M. Bugg,John W. Littlefield,Peter J. Donovan,Paul D. Blumenthal,George R. Huggins,John D. Gearhart +8 more
TL;DR: In this article, a set of primordial germ cells (PGCs, 5-9 weeks postfertilization) were cultured on mouse STO fibroblast feeder layers in the presence of human recombinant leukemia inhibitory factor (HILI) and forskolin.
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Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts.
TL;DR: A simple genetic manipulation can be used to select essentially pure cultures of cardiomyocytes from differentiating ES cells that are suitable for the formation of intracardiac grafts, and should be applicable to all ES-derived cell lineages.