Journal ArticleDOI
Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies.
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High levels of cardiomyocyte death occur for at least 4 days after grafting into injured hearts, in large part due to ischemia.About:
This article is published in Journal of Molecular and Cellular Cardiology.The article was published on 2001-05-01. It has received 873 citations till now. The article focuses on the topics: Cellular cardiomyoplasty & Necrosis.read more
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Cell therapy for cardiovascular regeneration.
TL;DR: The new advance in cardiovascular regeneration therapy from cardiac regeneration to cardiac re-organization is discussed, which is involved in recent progress of on-going clinical trials, basic research in cardiovascular regenerate, and the possibility of tissue engineering technology.
Journal ArticleDOI
Implantable and Biodegradable Macroporous Iron Oxide Frameworks for Efficient Regeneration and Repair of Infracted Heart.
Wenshuo Wang,Hongyue Tao,Yun Zhao,Xiaotian Sun,Jing Tang,Cordelia Selomulya,Jia Tang,Tianchan Chen,Yang Wang,Minglei Shu,Lei Wei,Guanyu Yi,Jixue Zhou,Lai Wei,Chunsheng Wang,Biao Kong +15 more
TL;DR: The construction, characterization and surgical application of a multilayered iron oxide-based macroporous composite framework demonstrated that the current framework might hold great potential for cardiac repair in patients with myocardial infraction.
Journal ArticleDOI
Generation of a Human Cardiac Patch Based on a Reendothelialized Biological Scaffold (BioVaSc)
Sebastian Schürlein,Reem Al Hijailan,Tobias Weigel,Asifiqbal Kadari,Christoph Rücker,Frank Edenhofer,Heike Walles,Jan Hansmann +7 more
TL;DR: A human cardiac patch is developed, using a biological collagen‐based vascularized scaffold (BioVaSc®), and constitutes a promising tool for drug development, in addition to its potential in clinical applications.
Journal ArticleDOI
Effects of Tongxinluo-facilitated cellular cardiomyoplasty with autologous bone marrow-mesenchymal stem cells on postinfarct swine hearts.
Hai-Yan Qian,Yuejin Yang,Ji Huang,Runlin Gao,Kefei Dou,Guosheng Yang,Jian-Jun Li,Rui Shen,Zuo-Xiang He,Minjie Lu,Shihua Zhao +10 more
TL;DR: In this article, the authors evaluated whether Tongxinluo (TXL) treatment around the transplantation of mesenchymal stem cells (MSCs) can improve survival and subsequent activities of implanted cells in swine hearts with acute myocardial infarction (AMI) and reperfusion.
References
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Journal ArticleDOI
Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
Journal ArticleDOI
Cellular survival: a play in three Akts
TL;DR: The mechanisms by which survival factors regulate the PI3K/c-Akt cascade, the evidence that activation of the PI 3K/ c-AKT pathway promotes cell survival, and the current spectrum of c- akt targets and their roles in mediating c- Akt-dependent cell survival are reviewed.
Journal Article
Apoptosis, oncosis, and necrosis : an overview of cell death
Guido Majno,Isabelle Joris +1 more
TL;DR: Some of the typical features of apoptosis are discussed, such as budding (as opposed to blebbing and zeiosis) and the inflammatory response, and stands in contrast to apoptosis, which leads to necrosis with karyorhexis and cell shrinkage.
Journal ArticleDOI
Derivation of pluripotent stem cells from cultured human primordial germ cells
Michael J. Shamblott,Joyce Axelman,Shunping Wang,Elizabeth M. Bugg,John W. Littlefield,Peter J. Donovan,Paul D. Blumenthal,George R. Huggins,John D. Gearhart +8 more
TL;DR: In this article, a set of primordial germ cells (PGCs, 5-9 weeks postfertilization) were cultured on mouse STO fibroblast feeder layers in the presence of human recombinant leukemia inhibitory factor (HILI) and forskolin.
Journal ArticleDOI
Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts.
TL;DR: A simple genetic manipulation can be used to select essentially pure cultures of cardiomyocytes from differentiating ES cells that are suitable for the formation of intracardiac grafts, and should be applicable to all ES-derived cell lineages.