Journal ArticleDOI
Catalytic asymmetric induction. Highly enantioselective addition of dialkylzincs to aldehydes
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This article is published in Journal of the American Chemical Society.The article was published on 1986-09-01. It has received 479 citations till now. The article focuses on the topics: Addition reaction & Enantioselective synthesis.read more
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Cooperative titanocene and phosphine catalysis: accelerated C-X activation for the generation of reactive organometallics.
TL;DR: It was discovered that phosphine ligands effectively accelerate the reductive transmetalation event to enable the metalation of C-X bonds at temperatures as low as -40 °C.
Journal ArticleDOI
Highly enantioselective synthesis of (E)-allylic alcohols.
TL;DR: In this article, the asymmetric addition of alkenylzincs to aromatic and α-branched aliphatic aldehydes catalyzed by 1 generated the corresponding ( £ )-allylic alcohols with >95% ee and good to excellent chemical yields.
Journal ArticleDOI
A homoannularly bridged hydroxyamino ferrocene as an efficient catalyst for the enantioselective ethylation of aromatic and aliphatic aldehydes.
TL;DR: In this article, eleven aromatic and aliphatic aldehydes have been alkylated with Et2Zn in the presence of the homoannularly bridged hydroxyamino ferrocene I.
Journal ArticleDOI
Chiral Ligands Derived from Abrine 8. An Experimental and Theoretical Study of Free Ligand Conformational Preferences and the Addition of Diethylzinc to Benzaldehyde
TL;DR: A structure was proposed for the transition state during ethyl group transfer when using ligands 8a-d and the change in enantioselectivity was successfully predicted when diastereomeric ligands 11 and 12 were compared in this chiral addition of diethylzinc to benzaldehyde.
Journal ArticleDOI
Chiral Schiff Bases as Highly Active and Enantioselective Catalysts in Catalytic Addition of Dialkylzinc to Aldehydes
TL;DR: Chiral Schiff base catalysts based on the ONO-tridentate ligand for the catalytic enantioselective addition of dialkylzinc to aldehydes have been developed and the catalyst loading minimum is decreased.
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