Journal ArticleDOI
Catalytic asymmetric induction. Highly enantioselective addition of dialkylzincs to aldehydes
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This article is published in Journal of the American Chemical Society.The article was published on 1986-09-01. It has received 479 citations till now. The article focuses on the topics: Addition reaction & Enantioselective synthesis.read more
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Journal ArticleDOI
Hydroxyamides versus amino alcohols in the enantioselective addition of diethylzinc to benzaldehyde
Tomás de las Casas Engel,Beatriz Lora Maroto,Antonio García Martínez,Santiago de la Moya Cerero +3 more
TL;DR: In this paper, two series of structurally related enantiopure isoborneols (10-amino and 10amino-10oxoisobornols) have been obtained from ketopinic acid and compared as chiral ligands for the enantioselective addition of diethylzinc to benzaldehyde in the absence of Ti(O-i -Pr) 4.
Journal ArticleDOI
Catalytic Asymmetric Alkylation of Aldehydes by Using Trialkylboranes
Takahiro Ukon,Toshiro Harada +1 more
TL;DR: Triethylborane can be used in the asymmetric alkylation of aldehydes by using a 3-(3,5-diphenylphenyl)-H8-BINOL-derived titanium(IV) catalyst in the presence of an excess amount of titanium tetraisopropoxide.
Journal ArticleDOI
Enantioselective Addition of Organozinc to Aldehydes and Ketones Catalyzed by Immobilized Chiral Ligands
Ratnasamy Somanathan,Lucía Z. Flores-López,Ruben Montalvo-Gonzalez,Daniel Chávez,Miguel Parra-Hake,Gerardo Aguirre +5 more
TL;DR: In this paper, the authors use catalytic enanti-lective addition of organozinc reagents to carbonyl groups is a valuable method for the synthesis of optically active alcohols.
Book ChapterDOI
1.7 – Organozinc, Organocadmium and Organomercury Reagents
TL;DR: The addition of organozinc compounds to aldehydes and ketones is of considerable synthetic utility as discussed by the authors, and it is possible to obtain high yields, good regioselectivity and, in some cases, excellent diastereoselectivities.
Journal ArticleDOI
Novel use of aryloxyaluminum dichloride in the chiral diamine mediated asymmetric addition reaction of grignard reagents to benzaldehyde
TL;DR: In this article, an asymmetric addition reaction of Grignard reagent-chiral diamine (1 or 2 ) complexes has been shown to afford the corresponding carbinols in good enantioselectivity.
Related Papers (5)
Enantioselective Addition of Organometallic Reagents to Carbonyl Compounds: Chirality Transfer, Multiplication, and Amplification†
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Enantioselective addition of diethylzinc to benzaldehyde catalyzed by a small amount of chiral 2-amino-1-alcohols
Nobuki Oguni,Takao Omi +1 more