Journal ArticleDOI
Catalytic asymmetric induction. Highly enantioselective addition of dialkylzincs to aldehydes
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This article is published in Journal of the American Chemical Society.The article was published on 1986-09-01. It has received 479 citations till now. The article focuses on the topics: Addition reaction & Enantioselective synthesis.read more
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Sulfur derivatives of ephedra alkaloids - new and highly efficient chiral catalysts
TL;DR: Sulfur derivatives of ephedrine catalyze the 1,2-addition of diethylzinc to benzaldehyde in high enantiomeric excess as discussed by the authors, and the actual catalytically active species, containing zinc, has been extracted from the reaction mixture.
Journal ArticleDOI
Catalytic Synthesis of Enantiopure Chiral Alcohols via Addition of Grignard Reagents to Carbonyl Compounds
TL;DR: In this paper, a review summarizes the developments in the enantioselective addition of Grignard reagents to carbonyl compounds has been made over the past decade.
Journal ArticleDOI
Chiral piperazine as a new chiral catalyst for the enantioselective addition of dialkyl zincs to aryl aldehydes
TL;DR: Optically active sec -alcohols in 90% enantiomeric excess were obtained from the enantioselective addition of dialkyl zincs to aryl aldehydes in the presence of a catalytic amount of dilithium salt of (2 S, 5 S )-2, 5-diisopropylpiperazine as discussed by the authors.
Journal ArticleDOI
Dual Stereoselectivity in the Dialkylzinc Reaction Using (-)-β-Pinene Derived Amino Alcohol Chiral Auxiliaries
Caitlin M. Binder,April Bautista,M. Zaidlewicz,Marek P. Krzemiński,Allen G. Oliver,Bakthan Singaram +5 more
TL;DR: Regioisomeric amino alcohols 2-MAP and 3-MAP, even though they were prepared from one enantiomer of nopinone, provide antipodal enantiofacial selectivity in the dialkylzinc addition reaction.
Journal ArticleDOI
Rigid aminoalcohol backbone as a highly defined chiral template for the preparation of optically active tertiary α-hydroxyl acids
Chris H. Senanayake,Kevin Q. Fang,Paul Grover,Roger P. Bakale,Charles P. Vandenbossche,Stephen A. Wald +5 more
TL;DR: Constrained amino alcohol derived-ketoester or amides have provided a new entry for the production of enantiopure acid 1 for (S)-oxybutynin this article.
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