Journal ArticleDOI
Catalytic asymmetric induction. Highly enantioselective addition of dialkylzincs to aldehydes
Reads0
Chats0
About:
This article is published in Journal of the American Chemical Society.The article was published on 1986-09-01. It has received 479 citations till now. The article focuses on the topics: Addition reaction & Enantioselective synthesis.read more
Citations
More filters
Journal ArticleDOI
Transformation of Amino Acids into Nonracemic 1‐(Heteroaryl)ethanamines by the Enamino Ketone Methodology
TL;DR: In this paper, Weinreb amides and ethynyl ketones were transformed into chiral enamino ketones, and deprotection by catalytic hydrogenation furnished free amines.
Journal ArticleDOI
Practical enantioselective reduction of ketones using oxazaborolidine catalyst generated in situ from chiral lactam alcohol and borane
TL;DR: In this paper, the borane reduction of various prochiral ketones with high enantioselectivity up to 98% was shown to be catalyzed by a reduction intermediate prepared in situ from chiral lactam alcohol 3 and boranes at room temperature.
Journal ArticleDOI
Approach to a better understanding and modeling of (S)-dihydrofuran-2-yl, (S)-tetrahydrofuran-2-yl-, and furan-2-yl-β-dialkylaminoethanol ligands for enantioselective alkylation
Claudio Paolucci,Goffredo Rosini +1 more
TL;DR: In this paper, the influence of an oxygen atom adjacent to the stereogenic center of β-amino alcohol derivatives used as ligands for catalysts in the asymmetric alkylation of aldehydes was investigated.
Journal ArticleDOI
Determination of Absolute Configuration of Secondary Alcohols Using Thin-Layer Chromatography
TL;DR: A new implementation of the competing enantioselective conversion (CEC) method was developed to qualitatively determine the absolute configuration of enantioenriched secondary alcohols using thin-layer chromatography.
Journal ArticleDOI
Asymmetric addition of diethylzinc to aromatic aldehydes by chiral ferrocene-based catalysts
Tae-Jeong Kim,Hee-Yeol Lee,Eun-Sook Ryu,Dong-Kyu Park,Chan Sik Cho,Sang Chul Shim,Jong Hwa Jeong +6 more
TL;DR: A series of chiral C1- and C2-symmetric ferrocenyl Schiff bases (1a-c), ferrocene amino alcohols (2a, 2b, 3), 1,1′-ferrocene-diol (3), and 1, 1′-Ferrocene disulfonamide (4) were employed as base catalysts or ligand for titanium(IV) complexes in the asymmetric addition of diethylzinc to aromatic aldehydes as mentioned in this paper.
Related Papers (5)
Enantioselective Addition of Organometallic Reagents to Carbonyl Compounds: Chirality Transfer, Multiplication, and Amplification†
Ryoji Noyori,Masato Kitamura +1 more
Enantioselective addition of diethylzinc to benzaldehyde catalyzed by a small amount of chiral 2-amino-1-alcohols
Nobuki Oguni,Takao Omi +1 more