Journal ArticleDOI
Catalytic asymmetric induction. Highly enantioselective addition of dialkylzincs to aldehydes
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This article is published in Journal of the American Chemical Society.The article was published on 1986-09-01. It has received 479 citations till now. The article focuses on the topics: Addition reaction & Enantioselective synthesis.read more
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Enantioselective ProPhenol-Catalyzed Addition of 1,3-Diynes to Aldehydes to Generate Synthetically Versatile Building Blocks and Diyne Natural Products
TL;DR: A highly enantioselective method for the catalytic addition of terminal 1,3-diynes to aldehydes was developed using the dinuclear zinc ProPhenol system and triphenylphosphine oxide was found to interact synergistically with the catalyst to substantially enhance the chiral recognition.
Journal ArticleDOI
A practical o-hydroxybenzylamines promoted enantioselective addition of dialkylzincs to aldehydes with asymmetric amplification
TL;DR: In this paper, a strong positive nonlinear relationship was observed for the reaction enantioselctivity with the use of o -hydroxybenzylamine 2e, which is very accessible through a short stereoselective synthetic route.
Journal ArticleDOI
Rationalization of enantioselectivities in dialkylzinc additions to benzaldehyde catalyzed by fenchone derivatives.
TL;DR: Predictions for ligand-tuning to improve catalyst efficiency of fenchone-based ligands in dialkylzinc additions to aldehydes are enabled.
Journal ArticleDOI
Enantioselective Reductive Coupling of Acetylene to N-Arylsulfonyl Imines via Rhodium Catalyzed C−C Bond-Forming Hydrogenation: (Z)-Dienyl Allylic Amines
TL;DR: The first highly enantioselective catalytic vinylation of aldimines to furnish allylic amines is reported, and the present protocol circumvents use of preformed organometallic reagents.
Journal ArticleDOI
Functional-group-tolerant, nickel-catalyzed cross-coupling reaction for enantioselective construction of tertiary methyl-bearing stereocenters.
TL;DR: The first Negishi nickel-catalyzed stereospecific cross-coupling reaction of secondary benzylic esters is reported and the utility of this transformation is highlighted in the enantioselective synthesis of a retinoic acid receptor agonist and a fatty acid amide hydrolase inhibitor.
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