Cell Division Intersects with Cell Geometry
James B. Moseley,Paul Nurse +1 more
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TLDR
Geometry-sensing mechanisms control both the decision to enter into cell division and the physical orientation of the chromosome segregation machinery, suggesting that signals controlling cell division may be linked to the mechanisms that ensure proper chromosome segregation.About:
This article is published in Cell.The article was published on 2010-07-23 and is currently open access. It has received 99 citations till now. The article focuses on the topics: Cell division & Division (mathematics).read more
Citations
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Journal ArticleDOI
Influence of Cell Geometry on Division-Plane Positioning
TL;DR: A simple computational model is developed that quantitatively predicts division-axis orientation probability for a wide variety of cell shapes, even in multicellular contexts, and estimates scaling exponents for length-dependent microtubule forces.
Journal ArticleDOI
Oscillations in the prefrontal cortex: a gateway to memory and attention.
TL;DR: The profound modifications of the PFC neuronal network associated with changes in oscillatory coherence are controlled by neuromodulators such as dopamine, which thereby allow or prevent the formation of cell assemblies for information encoding and storage.
Journal ArticleDOI
What can mice tell us about how vision works
TL;DR: Recent advances in understanding the mouse visual system at the anatomical, receptive field and perceptual level are discussed, focusing on the opportunities and constraints those features provide toward the goal of understanding how vision works.
Journal ArticleDOI
Tasks for inhibitory interneurons in intact brain circuits.
Lisa Roux,György Buzsáki +1 more
TL;DR: Recent techniques based on targeted expression of neuronal activity modulators, such as optogenetics, allow physiological identification and perturbation of specific interneuron subtypes in the intact brain and facilitate the understanding of the multiple roles of inhibitory interneurons in shaping circuit functions.
Journal ArticleDOI
The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia
TL;DR: Evidence that schizophrenia is associated with a reduction in N-methyl-d-aspartate receptor (NMDAR) function is reviewed to provide evidence for preferential disruption of GABAergic circuits in the context of NMDAR hypo-activity states.
References
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Journal ArticleDOI
Geometric control of cell life and death.
TL;DR: Human and bovine capillary endothelial cells were switched from growth to apoptosis by using micropatterned substrates that contained extracellular matrix-coated adhesive islands of decreasing size to progressively restrict cell extension.
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The extracellular matrix guides the orientation of the cell division axis
Manuel Théry,Victor Racine,A. Pépin,Matthieu Piel,Yong Chen,Jean-Baptiste Sibarita,Michel Bornens +6 more
TL;DR: It is proposed that the ECM controls the location of actin dynamics at the membrane, and thus the segregation of cortical components in interphase and mitosis and is maintained on the cortex of mitotic cells and used for spindle orientation.
Journal ArticleDOI
Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells
Toru Hirota,Toru Hirota,Toru Hirota,Naoko Kunitoku,Takashi Sasayama,Tomotoshi Marumoto,Dongwei Zhang,Masayuki Nitta,Katsuyoshi Hatakeyama,Hideyuki Saya +9 more
TL;DR: It is found that initial activation of Aurora-A in late G2 phase of the cell cycle is essential for recruitment of the cyclin B1-Cdk1 complex to centrosomes, where it becomes activated and commits cells to mitosis.
Journal ArticleDOI
How Cells Coordinate Growth and Division
Paul Jorgensen,Mike Tyers +1 more
TL;DR: This work has shown that in metazoans, cell cycles can be actively coupled to growth, but in certain cell types extracellular signals may independently induce growth and division.
Journal ArticleDOI
Assembly Dynamics of the Bacterial MinCDE System and Spatial Regulation of the Z Ring
TL;DR: The positioning of a cytoskeletal element that dictates the division plane is a fundamental problem in biology and the Min system consists of three proteins that cooperate to position the Z ring through a fascinating oscillation, which inhibits the formation of theZ ring away from midcell.
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