Chamber-Specific Cardiac Expression of Tbx5 and Heart Defects in Holt–Oram Syndrome
Benoit G. Bruneau,Malcolm Logan,Nicole M. Davis,Tatjana Levi,Tatjana Levi,Clifford J. Tabin,Jonathan G. Seidman,Jonathan G. Seidman,Christine E. Seidman,Christine E. Seidman +9 more
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TLDR
The role of T-box transcription factor, Tbx5, in cardiac development has been examined in the developing mouse and chick heart and correlated this pattern with cardiac defects caused by human TBX5 mutations in Holt-Oram syndrome.About:
This article is published in Developmental Biology.The article was published on 1999-07-01 and is currently open access. It has received 484 citations till now. The article focuses on the topics: Atrial septal defects & Cardiac chamber formation.read more
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Journal ArticleDOI
Isl1 Identifies a Cardiac Progenitor Population that Proliferates Prior to Differentiation and Contributes a Majority of Cells to the Heart
Chen-Leng Cai,Xingqun Liang,Yunqing Shi,Po Hsien Chu,Samuel L. Pfaff,Ju Chen,Sylvia M. Evans +6 more
TL;DR: Two sets of cardiogenic precursors are defined, one of which expresses and requires Isl1 and the other of which does not, which have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells.
Journal ArticleDOI
Human cardiovascular progenitor cells develop from a KDR + embryonic-stem-cell-derived population
Lei Yang,Mark H. Soonpaa,Eric Adler,Torsten K. Roepke,Steven J. Kattman,Marion Kennedy,Els Henckaerts,Kristina Bonham,Geoffrey W. Abbott,R. Michael Linden,R. Michael Linden,Loren J. Field,Gordon Keller,Gordon Keller +13 more
TL;DR: Analysis of the development of the cardiovascular lineages in human embryonic stem cell differentiation cultures identifies a human cardiovascular progenitor that defines one of the earliest stages of human cardiac development.
Journal ArticleDOI
Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling
Xiaojun Lian,Cheston Hsiao,Gisela F. Wilson,Kexian Zhu,Laurie B. Hazeltine,Samira M. Azarin,Kunil K. Raval,Kunil K. Raval,Jianhua Zhang,Jianhua Zhang,Timothy J. Kamp,Timothy J. Kamp,Sean P. Palecek +12 more
TL;DR: It is shown that temporal modulation of Wnt signaling is both essential and sufficient for efficient cardiac induction in hPSCs under defined, growth factor-free conditions.
Journal ArticleDOI
A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease
Benoit G. Bruneau,Georges Nemer,Joachim P. Schmitt,Frédéric Charron,Lynda Robitaille,Sophie Jeanne Cécile Caron,David A. Conner,David A. Conner,Manfred Gessler,Mona Nemer,Christine E. Seidman,Christine E. Seidman,Jonathan G. Seidman,Jonathan G. Seidman +13 more
TL;DR: These studies provide one potential explanation for Holt-Oram syndrome conduction system defects, suggest mechanisms for intrafamilial phenotypic variability, and account for related cardiac malformations caused by other transcription factor mutations.
Journal ArticleDOI
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation
Luika A. Timmerman,Joaquín Grego-Bessa,Angel Raya,Esther Bertran,José M. Pérez-Pomares,Juan Diez,Sergi Aranda,Sergio Palomo,Frank McCormick,Juan Carlos Izpisúa-Belmonte,José Luis de la Pompa +10 more
TL;DR: It is demonstrated that Notch activity promotes EMT during both cardiac development and oncogenic transformation via transcriptional induction of the Snail repressor, a potent and evolutionarily conserved mediator of EMT in many tissues and tumor types.
References
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A series of normal stages in the development of the chick embryo
TL;DR: The preparation of a series of normal stages of the chick embryo does not need justification at a time when chick ernbryos are not only widely used in descriptive and experimental embryology but are proving to be increasingly valuable in medical research, as in work on viruses and cancer.
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Sonic Hedgehog Mediates the Polarizing Activity of the ZPA
TL;DR: A vertebrate gene related to the Drosophila segment polarity gene hedgehog, which is expressed specifically in the ZPA and in other regions of the embryo, that is capable of polarizing limbs in grafting experiments is isolated.
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TL;DR: Assessment of Developmental Stage of Pre- and Postimplantation Mouse Embryos Based on the Staging System of Theiler (1989) and general Observations on the Urogenital Ridges, Gonads, and Genital Duct System.
Journal ArticleDOI
Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome.
Craig T. Basson,D. R. Bachinsky,R. C. Lin,Tatjana Levi,Jacob A. Elkins,Johanna Soults,David Grayzel,Elena Kroumpouzou,Thomas A. Traill,Janine M. LeBlanc-Straceski,Janine M. LeBlanc-Straceski,Beatrice Renault,Raju Kucherlapati,Jonathan G. Seidman,Christine E. Seidman +14 more
TL;DR: It is concluded that TBX5 is critical for limb and heart development and suggest that haploinsufficiency ofTBX5 causes Holt-Oram syndrome.
Journal ArticleDOI
Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury ( T ) gene family
Li Qy,Newbury-Ecob Ra,Newbury-Ecob Ra,Terrett Ja,David I. Wilson,Ann Curtis,Yi Ch,Gebuhr T,P Bullen,Stephen C. Robson,Tom Strachan,Damien Bonnet,Stanislas Lyonnet,Young Id,Raeburn Ja,Alan Buckler,Law Dj,J D Brook +17 more
TL;DR: Tissue in situ hybridization studies on human embryos from days 26 to 52 of gestation reveal expression of TBXS in heart and limb, consistent with a role in human embryonic development.