Characteristics of ischaemic stroke associated with COVID-19.
Rahma Beyrouti,Matthew Adams,Laura A Benjamin,Hannah Cohen,Simon F. Farmer,Yee Yen Goh,Fiona Humphries,Hans Rolf Jäger,Nicholas A Losseff,Nicholas A Losseff,Richard J. Perry,Sachit Shah,Robert Simister,David Turner,Arvind Chandratheva,David J. Werring +15 more
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TLDR
The demographic, clinical, radiological and laboratory characteristics of six consecutive patients assessed between 1 and 16 April 2020 at the National Hospital for Neurology and Neurosurgery, Queen Square, London, UK with acute ischaemic stroke and COVID-19 are described.Abstract:
Coronavirus disease 2019 (COVID19), caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) infection, is associated with coagulopathy causing venous and arterial thrombosis. 2 Recent data from the pandemic epicentre in Wuhan, China, reported neurological complications in 36% of 214 patients with COVID-19; acute cerebrovascular disease (mainly ischaemic stroke) was more common among 88 patients with severe COVID-19 than those with nonsevere disease (5.7% vs 0.8%). However, the mechanisms, phenotype and optimal management of ischaemic stroke associated with COVID-19 remain uncertain. We describe the demographic, clinical, radiological and laboratory characteristics of six consecutive patients assessed between 1 and 16 April 2020 at the National Hospital for Neurology and Neurosurgery, Queen Square, London, UK, with acute ischaemic stroke and COVID-19 (confirmed by reversetranscriptase PCR (RTPCR)) (table 1). All six patients had large vessel occlusion with markedly elevated Ddimer levels (≥1000μg/L). Three patients had multiterritory infarcts, two had concurrent venous thrombosis, and, in two, ischaemic strokes occurred despite therapeutic anticoagulation.read more
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Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study.
Aravinthan Varatharaj,Aravinthan Varatharaj,Naomi Thomas,Mark Ellul,Mark Ellul,Mark Ellul,Nicholas W. S. Davies,Thomas A Pollak,Elizabeth L Tenorio,Mustafa Sultan,Ava Easton,Gerome Breen,Michael S. Zandi,Jonathan P. Coles,Hadi Manji,Rustam Al-Shahi Salman,David K. Menon,Timothy R Nicholson,Laura A Benjamin,Laura A Benjamin,Alan Carson,Craig J. Smith,Martin R Turner,Tom Solomon,Tom Solomon,Tom Solomon,Rachel Kneen,Rachel Kneen,Sarah Pett,Ian Galea,Ian Galea,Rhys H. Thomas,Rhys H. Thomas,Benedict D Michael,Benedict D Michael,Benedict D Michael,Claire Allen,Neil Archibald,James Arkell,Peter Arthur-Farraj,Mark R. Baker,Harriet A. Ball,Verity Bradley-Barker,Zoe Brown,Stefania Bruno,Lois Carey,Christopher Carswell,Annie Chakrabarti,James Choulerton,Mazen Daher,Ruth Davies,Rafael Di Marco Barros,Sofia Dima,Rachel Dunley,Dipankar Dutta,Richard James Booth Ellis,Alex Everitt,Joseph Fady,Patricia Fearon,Leonora Fisniku,Ivie Gbinigie,Alan Gemski,Emma Gillies,Effrossyni Gkrania-Klotsas,Julie Grigg,Hisham Hamdalla,Jack Hubbett,Neil Hunter,Anne-Catherine Huys,Ihmoda Ihmoda,Sissi Ispoglou,Ashwani Jha,Ramzi Joussi,Dheeraj Kalladka,Hind Khalifeh,Sander Kooij,Guru Kumar,Sandar Kyaw,Lucia Li,Edward Littleton,Malcolm R. Macleod,Mary Joan MacLeod,Barbara Madigan,Vikram Mahadasa,Manonmani Manoharan,Richard Marigold,Isaac Marks,Paul M. Matthews,Michael Mccormick,Caroline Mcinnes,Antonio Metastasio,Philip Milburn-McNulty,Clinton Mitchell,Duncan Mitchell,Clare Morgans,Huw R. Morris,Jasper M. Morrow,Ahmed Mubarak Mohamed,Paula Mulvenna,Louis Murphy,Robert Namushi,Edward J Newman,Wendy Phillips,Ashwin Pinto,David A Price,Harald Proschel,Terry Quinn,Deborah Ramsey,Christine Roffe,Amy L Ross Russell,Neshika Samarasekera,Stephen Sawcer,Walee Sayed,Lakshmanan Sekaran,Jordi Serra-Mestres,Victoria K. Snowdon,Gayle Strike,James Sun,Christina Tang,Mark Vrana,Ryckie G. Wade,Chris Wharton,Lou Wiblin,Iryna Boubriak,Katie Herman,Gordon T. Plant +125 more
TL;DR: This is the first nationwide, cross-specialty surveillance study of acute neurological and psychiatric complications of COVID-19 and provides valuable and timely data that are urgently needed by clinicians, researchers, and funders.
Journal ArticleDOI
Neurological Associations of COVID-19
Mark Ellul,Laura A Benjamin,Bhagteshwar Singh,Suzannah Lant,Benedict D Michael,Benedict D Michael,Ava Easton,Rachel Kneen,Sylviane Defres,James Sejvar,Tom Solomon,Tom Solomon,Tom Solomon +12 more
TL;DR: The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is of a scale not seen since the 1918 influenza pandemic and the proportion of infections leading to neurological disease will probably remain small.
Journal ArticleDOI
The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings.
Ross W. Paterson,Ross W. Paterson,Rachel Brown,Laura A Benjamin,Laura A Benjamin,Ross Nortley,Ross Nortley,Sarah Wiethoff,Sarah Wiethoff,Tehmina Bharucha,Tehmina Bharucha,Tehmina Bharucha,Dipa L Jayaseelan,Dipa L Jayaseelan,Guru Kumar,Rhian E Raftopoulos,Laura Zambreanu,Laura Zambreanu,Vinojini Vivekanandam,Anthony Khoo,Ruth Geraldes,Ruth Geraldes,Krishna Chinthapalli,Krishna Chinthapalli,Elena Boyd,Hatice Tuzlali,Gary Price,Gerry Christofi,Jasper M. Morrow,Jasper M. Morrow,Patricia McNamara,Benjamin C Mcloughlin,Soon Tjin Lim,Puja Mehta,Viva Levee,Stephen Keddie,Wisdom Yong,S Anand Trip,S Anand Trip,Alexander J.M. Foulkes,Alexander J.M. Foulkes,Gary Hotton,Thomas D. Miller,Alex Everitt,Christopher Carswell,Nicholas W. S. Davies,Michael Yoong,David Attwell,Jemeen Sreedharan,Eli Silber,Jonathan M. Schott,Arvind Chandratheva,Richard J. Perry,Robert Simister,Anna M. Checkley,Nicky Longley,Simon F. Farmer,Francesco Carletti,Catherine F Houlihan,Maria Thom,Michael P. Lunn,Jennifer Spillane,Jennifer Spillane,Robin Howard,Robin Howard,Angela Vincent,Angela Vincent,David J. Werring,Chandrashekar Hoskote,Hans Rolf Jäger,Hans Rolf Jäger,Hadi Manji,Hadi Manji,Michael S. Zandi,Michael S. Zandi +74 more
TL;DR: A case series of 43 patients with neurological complications of SARS-CoV-2 infection includes encephalopathies, encephalitis, acute disseminated encephalomyelitis with haemorrhagic change, transverse myelitis, ischaemic stroke, and Guillain-Barré syndrome.
Journal ArticleDOI
Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia.
David H. Brann,Tatsuya Tsukahara,Caleb Weinreb,Marcela Lipovsek,Koen Van den Berge,Koen Van den Berge,Boying Gong,Rebecca K. Chance,Iain C. Macaulay,Hsin-jung Chou,Russell B. Fletcher,Diya Das,Diya Das,Kelly Street,Hector Roux de Bézieux,Yoon Gi Choi,Davide Risso,Sandrine Dudoit,Elizabeth Purdom,Jonathan Mill,Ralph Abi Hachem,Hiroaki Matsunami,Darren W. Logan,Bradley J. Goldstein,Matthew S. Grubb,John Ngai,Sandeep Robert Datta +26 more
TL;DR: It is suggested that CoV-2 infection of non-neuronal cell types leads to anosmia and related disturbances in odor perception in COVID-19 patients.
Journal ArticleDOI
Platelet gene expression and function in patients with COVID-19.
Bhanu Kanth Manne,Frederik Denorme,Elizabeth A. Middleton,Irina Portier,Jesse W. Rowley,Chris Stubben,Aaron C. Petrey,Neal D. Tolley,Li Guo,Mark J. Cody,Andrew S. Weyrich,Christian C. Yost,Matthew T. Rondina,Robert A. Campbell +13 more
TL;DR: It is demonstrated that SARS-CoV-2 infection is associated with platelet hyperreactivity, which may contribute to COVID-19 pathophysiology.
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