Characterization of a novel coronavirus associated with severe acute respiratory syndrome.
Paul A. Rota,M. Steven Oberste,Stephan S. Monroe,W. Allan Nix,Ray Campagnoli,Joseph P. Icenogle,Silvia Peñaranda,Bettina Bankamp,Kaija Maher,Min hsin Chen,Suxiong Tong,Azaibi Tamin,Luis Lowe,Michael Frace,Joseph L. DeRisi,Qi Chen,David Wang,Dean D. Erdman,Teresa C. T. Peret,Cara C. Burns,Thomas G. Ksiazek,Pierre E. Rollin,Anthony Sanchez,Stephanie L. Liffick,Brian P. Holloway,Josef Limor,Karen A. McCaustland,Mellissa Olsen-Rasmussen,Ron A. M. Fouchier,Stephan Günther,Albert Osterhaus,Christian Drosten,Mark A. Pallansch,Larry J. Anderson,William J. Bellini +34 more
TLDR
Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closelyrelated to any of the previouslycharacterized coronaviruses.Citations
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Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
Wenhui Li,Michael Moore,Natalya Vasilieva,Jianhua Sui,Swee Kee Wong,Michael A. Berne,Mohan Somasundaran,John L. Sullivan,Katherine Luzuriaga,Thomas C. Greenough,Hyeryun Choe,Michael Farzan +11 more
TL;DR: It is found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells, indicating that ACE2 is a functional receptor for SARS-CoV.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
Keiji Kuba,Yumiko Imai,Shuan Rao,Hong Gao,Feng Guo,Bin Guan,Yi Huan,Peng Yang,Yanli Zhang,Wei Deng,Linlin Bao,Binlin Zhang,Guang Liu,Zhong Wang,Mark C. Chappell,Yanxin Liu,Dexian Zheng,Andreas Leibbrandt,Teiji Wada,Arthur S. Slutsky,Depei Liu,Chuan Qin,Chengyu Jiang,Josef M. Penninger +23 more
TL;DR: A molecular explanation why SARS-CoV infections cause severe and often lethal lung failure and suggest a rational therapy for SARS and possibly other respiratory disease viruses is provided.
Journal ArticleDOI
Bats are natural reservoirs of SARS-like coronaviruses.
Wendong Li,Zhengli Shi,Meng Yu,Wuze Ren,Craig Smith,Jonathan H. Epstein,Hanzhong Wang,Gary Crameri,Zhihong Hu,Huajun Zhang,Jianhong Zhang,Jennifer A. McEachern,Hume Field,Peter Daszak,Bryan T. Eaton,Shuyi Zhang,Lin-Fa Wang +16 more
TL;DR: It is reported that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak, and these viruses display greater genetic variation than SARS-CoV isolated from humans or from civets.
Journal ArticleDOI
The severe acute respiratory syndrome.
TL;DR: The concerted and coordinated response that contained SARS is a triumph for global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats.
References
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Journal ArticleDOI
Coronavirus as a possible cause of severe acute respiratory syndrome
Jsm Peiris,Sik To Lai,Llm Poon,Yi Guan,Lyc Yam,Wilina Lim,John M. Nicholls,Wks Yee,WW Yan,MT Cheung,V. C. C. Cheng,KH Chan,Dnc Tsang,R Yung,Ting Kin Ng,KY Yuen +15 more
TL;DR: Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression.
Journal ArticleDOI
Full-Length Human Immunodeficiency Virus Type 1 Genomes from Subtype C-Infected Seroconverters in India, with Evidence of Intersubtype Recombination
Kavita S. Lole,Robert C. Bollinger,Ramesh S. Paranjape,Deepak A. Gadkari,Smita Kulkarni,Nicole G. Novak,Roxann G. Ingersoll,Haynes W. Sheppard,Stuart C. Ray +8 more
TL;DR: Because these clones were obtained from Indian seroconverters, they are likely to facilitate vaccine-related efforts in India by providing potential antigens for vaccine candidates as well as for assays of vaccine responsiveness.
Journal ArticleDOI
The Genome Sequence of the SARS-associated Coronavirus
Marco A. Marra,Steven J.M. Jones,Caroline R. Astell,Robert A. Holt,Angela Brooks-Wilson,Yaron S.N. Butterfield,Jaswinder Khattra,Jennifer Asano,Sarah Barber,Susanna Y. Chan,Alison Cloutier,Shaun M. Coughlin,Doug Freeman,Noreen Girn,Obi L. Griffith,Stephen Leach,Michael Mayo,Helen McDonald,Stephen B. Montgomery,Pawan Pandoh,Anca Petrescu,A. Gordon Robertson,Jacqueline E. Schein,Asim Siddiqui,Duane E. Smailus,Jeff M. Stott,George S. Yang,Francis A. Plummer,Anton Andonov,Harvey Artsob,Nathalie Bastien,Kathy Bernard,Timothy F. Booth,Donnie Bowness,Martin Czub,Michael Drebot,Lisa Fernando,Ramon Flick,Michael Garbutt,Michael Gray,Allen Grolla,Steven M. Jones,Heinz Feldmann,Adrienne Meyers,Amin Kabani,Yan Li,Susan Normand,Ute Ströher,Graham A. Tipples,Shaun Tyler,Robert Vogrig,Diane M. Ward,Brynn Watson,Robert C. Brunham,Mel Krajden,Martin Petric,Danuta M. Skowronski,Chris Upton,Rachel L. Roper +58 more
TL;DR: The genome sequence reveals that the severe acute respiratory syndrome–associated coronavirus known as the Tor2 isolate is only moderately related to other known coronaviruses, andylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronavirs.
Journal ArticleDOI
Virus-encoded proteinases and proteolytic processing in the Nidovirales.
TL;DR: This paper presents a meta-anatomy of the EMMARM, a probabilistic model of the immune response to EMT, which states that EMTs are more likely to attack the nervous system than the immune systems of mice.
Journal ArticleDOI
Virus Maturation by Budding
TL;DR: It is proposed that the budding of enveloped viruses in general is governed by lateral interactions between peripheral or integral membrane proteins, which has implications for the mechanism by which the virion is uncoated during virus entry.
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