Journal ArticleDOI
Comparison of GEANT4 very low energy cross section models with experimental data in water.
Sebastien Incerti,A. Ivanchenko,M. Karamitros,A. Mantero,Philippe Moretto,H.N. Tran,B. Mascialino,Christophe Champion,Vladimir Ivanchenko,Mario A. Bernal,Ziad Francis,Carmen Villagrasa,G. Baldacchino,Paul Gueye,R. Capra,Pentti Nieminen,C. Zacharatou +16 more
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TLDR
The results show that microdosimetric measurements in liquid water are necessary to assess quantitatively the validity of the software implementation for the liquid water phase, and represent a first step in the extension of the GEANT4 Monte Carlo toolkit to the simulation of biological effects of ionizing radiation.Abstract:
Purpose: TheGEANT4 general-purpose Monte Carlo simulation toolkit is able to simulate physical interaction processes of electrons, hydrogen and helium atoms with charge states ( H 0 , H + ) and ( He 0 , He + , He 2 + ), respectively, in liquid water, the main component of biological systems, down to the electron volt regime and the submicrometer scale, providing GEANT4 users with the so-called “GEANT4-DNA” physics models suitable for microdosimetry simulation applications. The corresponding software has been recently re-engineered in order to provide GEANT4 users with a coherent and unique approach to the simulation of electromagnetic interactions within the GEANT4 toolkit framework (since GEANT4 version 9.3 beta). This work presents a quantitative comparison of these physics models with a collection of experimental data in water collected from the literature. Methods: An evaluation of the closeness between the total and differential cross section models available in theGEANT4 toolkit for microdosimetry and experimental reference data is performed using a dedicated statistical toolkit that includes the Kolmogorov–Smirnov statistical test. The authors used experimental data acquired in water vapor as direct measurements in the liquid phase are not yet available in the literature. Comparisons with several recommendations are also presented. Results: The authors have assessed the compatibility of experimental data withGEANT4microdosimetry models by means of quantitative methods. The results show that microdosimetric measurements in liquid water are necessary to assess quantitatively the validity of the software implementation for the liquid water phase. Nevertheless, a comparison with existing experimental data in water vapor provides a qualitative appreciation of the plausibility of the simulation models. The existing reference data themselves should undergo a critical interpretation and selection, as some of the series exhibit significant deviations from each other. Conclusions: TheGEANT4-DNA physics models available in the GEANT4 toolkit have been compared in this article to available experimental data in the water vapor phase as well as to several published recommendations on the mass stopping power. These models represent a first step in the extension of the GEANT4 Monte Carlo toolkit to the simulation of biological effects of ionizing radiation.read more
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Journal ArticleDOI
Recent developments in GEANT4
John Allison,K. Amako,John Apostolakis,Pedro Arce,Makoto Asai,Tsukasa Aso,Enrico Bagli,Alexander Bagulya,Sw. Banerjee,G. Barrand,B. R. Beck,Alexey Bogdanov,D. Brandt,Jeremy M. C. Brown,Helmut Burkhardt,Ph Canal,D. Cano-Ott,Stephane Chauvie,Kyung-Suk Cho,G.A.P. Cirrone,Gene Cooperman,M. A. Cortés-Giraldo,G. Cosmo,Giacomo Cuttone,G.O. Depaola,Laurent Desorgher,X. Dong,Andrea Dotti,Victor Daniel Elvira,Gunter Folger,Ziad Francis,A. Galoyan,L. Garnier,M. Gayer,K. Genser,Vladimir Grichine,Vladimir Grichine,Susanna Guatelli,Susanna Guatelli,Paul Gueye,P. Gumplinger,Alexander Howard,Ivana Hřivnáčová,S. Hwang,Sebastien Incerti,Sebastien Incerti,A. Ivanchenko,Vladimir Ivanchenko,F.W. Jones,S. Y. Jun,Pekka Kaitaniemi,Nicolas A. Karakatsanis,Nicolas A. Karakatsanis,M. Karamitrosi,M.H. Kelsey,Akinori Kimura,Tatsumi Koi,Hisaya Kurashige,A. Lechner,S. B. Lee,Francesco Longo,M. Maire,Davide Mancusi,A. Mantero,E. Mendoza,B. Morgan,K. Murakami,T. Nikitina,Luciano Pandola,P. Paprocki,J Perl,Ivan Petrović,Maria Grazia Pia,W. Pokorski,J. M. Quesada,M. Raine,Maria A.M. Reis,Alberto Ribon,A. Ristic Fira,Francesco Romano,Giorgio Ivan Russo,Giovanni Santin,Takashi Sasaki,D. Sawkey,J. I. Shin,Igor Strakovsky,A. Taborda,Satoshi Tanaka,B. Tome,Toshiyuki Toshito,H.N. Tran,Pete Truscott,L. Urbán,V. V. Uzhinsky,Jerome Verbeke,M. Verderi,B. Wendt,H. Wenzel,D. H. Wright,Douglas Wright,T. Yamashita,J. Yarba,H. Yoshida +102 more
TL;DR: Geant4 as discussed by the authors is a software toolkit for the simulation of the passage of particles through matter, which is used by a large number of experiments and projects in a variety of application domains, including high energy physics, astrophysics and space science, medical physics and radiation protection.
Journal ArticleDOI
Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit
Mario A. Bernal,Marie-Claude Bordage,Jeremy M. C. Brown,Jeremy M. C. Brown,Marie Davídková,E. Delage,Z. El Bitar,Shirin A. Enger,Ziad Francis,Susanna Guatelli,Vladimir Ivanchenko,M. Karamitros,Ioanna Kyriakou,Lydia Maigne,Sylvain Meylan,K. Murakami,Shogo Okada,H. Payno,Yann Perrot,Ivan Petrović,Q.T. Pham,Aleksandra Ristić-Fira,Takashi Sasaki,Václav Štěpán,H.N. Tran,Carmen Villagrasa,Sebastien Incerti +26 more
TL;DR: This paper presents the most recent review of the Geant4-DNA extension, as available to Geant 4 users since June 2015 (release 10.2 Beta), and includes the description of new physical models for thedescription of electron elastic and inelastic interactions in liquid water, as well as new examples dedicated to the simulation of physicochemical and chemical stages of water radiolysis.
Journal ArticleDOI
A review of the use and potential of the GATE Monte Carlo simulation code for radiation therapy and dosimetry applications
David Sarrut,Manuel Bardiès,Nicolas Boussion,Nicolas Freud,Sébastien Jan,Jean Michel Létang,George Loudos,Lydia Maigne,Sara Marcatili,Thibault Mauxion,Panagiotis Papadimitroulas,Yann Perrot,Uwe Pietrzyk,Charlotte Robert,Dennis R. Schaart,Dimitris Visvikis,Irène Buvat +16 more
TL;DR: The authors' review the applicability of the open-source GATE Monte Carlo simulation platform based on the GEANT4 toolkit for radiation therapy and dosimetry applications and the computational times associated with several applications are provided to illustrate the practical feasibility of the simulations using current computing facilities.
Journal ArticleDOI
Geant4-DNA example applications for track structure simulations in liquid water: A report from the Geant4-DNA Project.
Sebastien Incerti,Sebastien Incerti,Ioanna Kyriakou,Mario A. Bernal,Marie-Claude Bordage,Marie-Claude Bordage,Ziad Francis,Susanna Guatelli,Susanna Guatelli,Vladimir Ivanchenko,M. Karamitros,Nathanael Lampe,Sang Bae Lee,Sylvain Meylan,Chul Hee Min,Wook Geun Shin,Pentti Nieminen,Dosatsu Sakata,Dosatsu Sakata,Dosatsu Sakata,Nicolas Tang,Carmen Villagrasa,H.N. Tran,Jeremy M. C. Brown +23 more
TL;DR: This Special Report presents a description of Geant4-DNA user applications dedicated to the simulation of track structures (TS) in liquid water and associated physical quantities (e.g., range, stopping power, mean free path…) and shows that the most recent sets of physics models available in Geant 4-DNA enable more accurate simulation of stopping powers, dose point kernels, and W-values in liquidWater.
Journal ArticleDOI
Radiation track, DNA damage and response—a review
Hooshang Nikjoo,Dimitris Emfietzoglou,T. Liamsuwan,Reza Taleei,David Liljequist,Shuzo Uehara +5 more
TL;DR: It is hypothesized that concepts of condensed-matter physics along with the new genomic knowledge and technologies and mechanistic mathematical modeling in conjunction with advances in experimental DNA repair and cell signaling have now provided us with unprecedented opportunities in radiation biophysics to address problems in targeted cancer therapy, and genetic risk estimation in humans.
References
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Journal ArticleDOI
Geant4—a simulation toolkit
S. Agostinelli,John Allison,K. Amako,J. Apostolakis,Henrique Araujo,P. Arce,Makoto Asai,D. Axen,S. Banerjee,G. Barrand,F. Behner,Lorenzo Bellagamba,J. Boudreau,L. Broglia,A. Brunengo,H. Burkhardt,Stephane Chauvie,J. Chuma,R. Chytracek,Gene Cooperman,G. Cosmo,P. V. Degtyarenko,Andrea Dell'Acqua,G. Depaola,D. Dietrich,R. Enami,A. Feliciello,C. Ferguson,H. Fesefeldt,Gunter Folger,Franca Foppiano,Alessandra Forti,S. Garelli,S. Gianì,R. Giannitrapani,D. Gibin,J. J. Gomez Y Cadenas,I. González,G. Gracia Abril,G. Greeniaus,Walter Greiner,Vladimir Grichine,A. Grossheim,Susanna Guatelli,P. Gumplinger,R. Hamatsu,K. Hashimoto,H. Hasui,A. Heikkinen,A. S. Howard,Vladimir Ivanchenko,A. Johnson,F.W. Jones,J. Kallenbach,Naoko Kanaya,M. Kawabata,Y. Kawabata,M. Kawaguti,S.R. Kelner,Paul R. C. Kent,A. Kimura,T. Kodama,R. P. Kokoulin,M. Kossov,Hisaya Kurashige,E. Lamanna,Tapio Lampén,V. Lara,Veronique Lefebure,F. Lei,M. Liendl,W. S. Lockman,Francesco Longo,S. Magni,M. Maire,E. Medernach,K. Minamimoto,P. Mora de Freitas,Yoshiyuki Morita,K. Murakami,M. Nagamatu,R. Nartallo,Petteri Nieminen,T. Nishimura,K. Ohtsubo,M. Okamura,S. W. O'Neale,Y. Oohata,K. Paech,J Perl,Andreas Pfeiffer,Maria Grazia Pia,F. Ranjard,A.M. Rybin,S.S Sadilov,E. Di Salvo,Giovanni Santin,Takashi Sasaki,N. Savvas,Y. Sawada,Stefan Scherer,S. Sei,V. Sirotenko,David J. Smith,N. Starkov,H. Stoecker,J. Sulkimo,M. Takahata,Satoshi Tanaka,E. Tcherniaev,E. Safai Tehrani,M. Tropeano,P. Truscott,H. Uno,L. Urbán,P. Urban,M. Verderi,A. Walkden,W. Wander,H. Weber,J.P. Wellisch,Torre Wenaus,D.C. Williams,Douglas Wright,T. Yamada,H. Yoshida,D. Zschiesche +126 more
TL;DR: The Gelfant 4 toolkit as discussed by the authors is a toolkit for simulating the passage of particles through matter, including a complete range of functionality including tracking, geometry, physics models and hits.
Journal ArticleDOI
EDF Statistics for Goodness of Fit and Some Comparisons
TL;DR: In this paper, a practical guide to goodness-of-fit tests using statistics based on the empirical distribution function (EDF) is presented, and five of the leading statistics are examined.
Journal ArticleDOI
THE Geant4-DNA project
Sebastien Incerti,G. Baldacchino,Mario A. Bernal,R. Capra,Christophe Champion,Ziad Francis,Paul Gueye,A. Mantero,B. Mascialino,Philippe Moretto,Petteri Nieminen,Carmen Villagrasa,C. Zacharatou +12 more
TL;DR: An overview of the whole on-going Geant4-DNA project is presented, including its most recent developments that are available in the Geant 4 toolkit since December 2009, as well as an illustration example simulating the direct irradiation of a biological chromatin fiber.
Posted Content
The Geant4-DNA project
Sebastien Incerti,G. Baldacchino,Mario A. Bernal,R. Capra,Christophe Champion,Ziad Francis,Susanna Guatelli,Paul Gueye,A. Mantero,B. Mascialino,Philippe Moretto,Pentti Nieminen,Anatoly B. Rosenfeld,Carmen Villagrasa,C. Zacharatou +14 more
TL;DR: The Geant4-DNA project as mentioned in this paper proposes to develop an open-source simulation software based and fully included in the general-purpose geant4 Monte Carlo simulation toolkit, which is used to simulate biological damages induced by ionising radiation at the cellular and sub-cellular scale.
Journal ArticleDOI
Collective oscillation in liquid water
TL;DR: In this paper, the optical properties of liquid water were extended in the vacuum ultraviolet up to an energy of 25.6 eV and the indices of refraction and dielectric functions were obtained by a Kramers-Kronig analysis.
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Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit
Mario A. Bernal,Marie-Claude Bordage,Jeremy M. C. Brown,Jeremy M. C. Brown,Marie Davídková,E. Delage,Z. El Bitar,Shirin A. Enger,Ziad Francis,Susanna Guatelli,Vladimir Ivanchenko,M. Karamitros,Ioanna Kyriakou,Lydia Maigne,Sylvain Meylan,K. Murakami,Shogo Okada,H. Payno,Yann Perrot,Ivan Petrović,Q.T. Pham,Aleksandra Ristić-Fira,Takashi Sasaki,Václav Štěpán,H.N. Tran,Carmen Villagrasa,Sebastien Incerti +26 more
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