Journal ArticleDOI
Conformational change as one of the earliest alterations of tau in Alzheimer’s disease
Reads0
Chats0
TLDR
It is suggested that the formation of the MCI epitope is one of the earliest pathological alterations of tau in AD.About:
This article is published in Neurobiology of Aging.The article was published on 2000-09-01. It has received 297 citations till now. The article focuses on the topics: Neurofibrillary tangle & Tau protein.read more
Citations
More filters
Journal ArticleDOI
Neuropathological Alterations in Alzheimer Disease
TL;DR: Postmortem studies have enabled the staging of the progression of both amyloid and tangle pathologies, and the development of diagnostic criteria that are now used worldwide, and these cross-sectional neuropathological data have been largely validated by longitudinal in vivo studies using modern imaging biomarkers such as amyloids PET and volumetric MRI.
Journal ArticleDOI
Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury.
Ann C. McKee,Robert C. Cantu,Christopher J. Nowinski,E. Tessa Hedley-Whyte,Brandon E. Gavett,Andrew E. Budson,Veronica Santini,H. J. Lee,Caroline A. Kubilus,Robert S. Stern +9 more
TL;DR: This work reviews 48 cases of neuropathologically verified CTE recorded in the literature and document the detailed findings of CTE in 3 professionalathletes, 1 football player and 2 boxers.
Journal ArticleDOI
Trans-Synaptic Spread of Tau Pathology In Vivo
Li Liu,Valerie Drouet,Jessica W. Wu,Menno P. Witter,Scott A. Small,Catherine L. Clelland,Karen Duff +6 more
TL;DR: The mouse recapitulates the tauopathy that defines the early stages of AD and provides a model for testing mechanisms and functional outcomes associated with disease progression and support a trans-synaptic mechanism of spread along anatomically connected networks, between connected and vulnerable neurons.
Journal ArticleDOI
Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome
TL;DR: It is shown that Abeta immunotherapy reduces not only extracellular Abeta plaques but also intracellular AbETA accumulation and most notably leads to the clearance of early tau pathology.
Journal ArticleDOI
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
Wendy Noble,Emmanuel Planel,Cindy Zehr,Vicki Olm,Jordana L Meyerson,Farhana Suleman,Kate Gaynor,Lili Wang,John LaFrancois,Boris Feinstein,Mark P. Burns,Pavan Krishnamurthy,Yi Wen,Ratan Bhat,Jada Lewis,Dennis W. Dickson,Karen Duff +16 more
TL;DR: Results support the idea that kinases are involved in tauopathy progression and that kinase inhibitors may be effective therapeutically and that lithium exerts its effect through GSK-3 inhibition.
References
More filters
Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TL;DR: The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.
Journal ArticleDOI
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.
Gregory T. Bramblett,Michel Goedert,Ross Jakes,Sandra E. Merrick,John Q. Trojanowski,Virginia M.-Y. Lee +5 more
TL;DR: It is demonstrated that native A68 does not bind to microtubules (MTs), yet dephosphorylated A68 regains the ability to bind to MTs, and phosphorylation of Ser396 may destabilize MTs in AD, resulting in the degeneration of affected cells.
Journal ArticleDOI
Staging of Alzheimer-Related Cortical Destruction
TL;DR: The patterns of staining typically found with each of these techniques in the brains of patients with progressively severe AD are described and how the specific changes observed can be used as a staging system for diagnostic purposes are described.
Journal ArticleDOI
Tau protein and the neurofibrillary pathology of Alzheimer's disease.
TL;DR: Current evidence suggests that protein kinases or protein phosphatases with a specificity for serine/threonine-proline residues are involved in the abnormal phosphorylation of tau.
Journal ArticleDOI
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
Eriko S. Matsuo,Ryong Woon Shin,Melvin L. Billingsley,Andre Van deVoorde,Michael J. O'Connor,John Q. Trojanowski,Virginia M.-Y. Lee +6 more
TL;DR: Examination of human adult tau from brain biopsies demonstrated that biopsy-derived tau is phosphorylated at most sites thought to be abnormally phosphorylate tau, suggesting that the down-regulation of phosphatases in the AD brain could lead to the generation of maximallyosphorylated PHF-tau that does not bind microtubules and aggregates as PHFs in neurofibrillary tangles and dystrophic neurites.
Related Papers (5)
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Mike Hutton,Corinne Lendon,Patrizia Rizzu,Matt Baker,Susanne Froelich,Susanne Froelich,Henry Houlden,Stuart Pickering-Brown,Sumitra Chakraverty,Adrian M. Isaacs,Andrew Grover,J. Hackett,Jennifer Adamson,Sarah Lincoln,Dennis W. Dickson,Peter Davies,Ronald C. Petersen,M. Stevens,E. De Graaff,E. Wauters,J. Van Baren,M. Hillebrand,Marijke Joosse,J. M. Kwon,Petra Nowotny,Lien Kuei Che,Joanne Norton,John C. Morris,L. A. Reed,John Q. Trojanowski,Hans Basun,Lars Lannfelt,M. Neystat,Stanley Fahn,Frances Dark,Tony Tannenberg,Peter R. Dodd,Nicholas K. Hayward,John B.J. Kwok,Peter R. Schofield,Athena Andreadis,Julie S. Snowden,David Craufurd,David Neary,F. Owen,Ben A. Oostra,John Hardy,Alison Goate,J. C. van Swieten,David M. A. Mann,Timothy Lynch,Peter Heutink +51 more