Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling.
Kristi L. Norris,Rui Hao,Liang-Fu Chen,Chun-Hsiang Lai,Meghan Kapur,Peter J. Shaughnessy,Dennis Chou,Jin Yan,J. Paul Taylor,Simone Engelender,Anna E. West,Kah-Leong Lim,Tso-Pang Yao +12 more
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TLDR
Under moderate mitochondrial stress conditions, parkin stimulates mitochondrial fusion instead of mitophagy by catalyzing K63-linked ubiquitination and inactivating α-synuclein, which provides a physiological context to functionally connect key PARK genes in the pathogenesis of Parkinson disease.About:
This article is published in Journal of Biological Chemistry.The article was published on 2015-05-29 and is currently open access. It has received 74 citations till now. The article focuses on the topics: Parkin & PINK1.read more
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Oxidative stress and Parkinson’s disease
TL;DR: A mini review of the classical pathways involving these mechanisms of neurodegeneration, the biochemical and molecular events that mediate or regulate DA neuronal vulnerability, and the role of PD-related gene products in modulating cellular responses to oxidative stress in the course of the Neurodegenerative process are given.
Journal ArticleDOI
Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease.
TL;DR: Understanding the common nature of interactions among these three damage mechanisms may help to identify putative neuroprotective strategies that would be beneficial in both the clinical conditions.
Journal ArticleDOI
Regulators of mitochondrial dynamics in cancer.
Daniela Senft,Ze'ev Ronai +1 more
TL;DR: This review focuses on key regulators of mitochondrial dynamics and their role in cancer.
Journal ArticleDOI
Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism
Xia Gao,Katie Lee,Michael A. Reid,Sydney M. Sanderson,Chuping Qiu,Siqi Li,Juan Liu,Jason W. Locasale +7 more
TL;DR: A role for serine in supporting mitochondrial function and cell proliferation through ceramide metabolism is defined, and supplementation of the lipid component of bovine serum or C16:0-ceramide could partially restore defects in cell proliferation and mitochondrial fragmentation induced by serine deprivation.
Journal ArticleDOI
Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.
Anna Villar-Piqué,Tomás Lopes da Fonseca,Tomás Lopes da Fonseca,Tiago F. Outeiro,Tiago F. Outeiro,Tiago F. Outeiro +5 more
TL;DR: Establishing whether alpha‐synuclein has a causative role in all synucleinopathies will enable the identification of targets for the development of novel therapeutic strategies for this devastating group of disorders.
References
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Journal ArticleDOI
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
TL;DR: It is reported that chronic, systemic inhibition of complex I by the lipophilic pesticide, rotenone, causes highly selective nigrostriatal dopaminergic degeneration that is associated behaviorally with hypokinesia and rigidity.
Journal ArticleDOI
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
TL;DR: It is shown that Parkin is selectively recruited to dysfunctional mitochondria with low membrane potential in mammalian cells and this recruitment promotes autophagy of damaged mitochondria and implicate a failure to eliminate dysfunctional mitochondira in the pathogenesis of Parkinson's disease.
Journal ArticleDOI
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.
Derek P. Narendra,Seok Min Jin,Atsushi Tanaka,Der-Fen Suen,Clement A. Gautier,Jie Shen,Mark R. Cookson,Richard J. Youle +7 more
TL;DR: The authors suggest that PINK1 and Parkin form a pathway that senses damaged mitochondria and selectively targets them for degradation.
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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Sven Geisler,Kira M. Holmström,Diana Skujat,Fabienne C. Fiesel,Oliver Rothfuss,Philipp J. Kahle,Wolfdieter Springer +6 more
TL;DR: Functional links between PINK1, Parkin and the selective autophagy of mitochondria, which is implicated in the pathogenesis of Parkinson's disease, are provided.
Journal ArticleDOI
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
TL;DR: It is concluded that Mfn1 and Mfn2 have both redundant and distinct functions and act in three separate molecular complexes to promote mitochondrial fusion, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population.
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