Cytokine Storm.
David C. Fajgenbaum,Carl H. June +1 more
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From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory, and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia.Abstract:
From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory (D.C.F.), and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy (C.H.J.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. Address reprint requests to Dr. Fajgenbaum at davidfa@ pennmedicine . upenn . edu or to Dr. June at cjune@ upenn . edu.read more
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IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis
Josephine Diony Nanda,Tzong-Shiann Ho,Tzong-Shiann Ho,Rahmat Dani Satria,Rahmat Dani Satria,Ming-Kai Jhan,Yung-Ting Wang,Chiou Feng Lin +7 more
TL;DR: In this paper, the potential immunopathogenic role of IL-18 when it participates in DENV infection and dengue disease progression was discussed based on existing findings and related past studies.
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Prime-Boost Vaccination With Covaxin/BBV152 Induces Heightened Systemic Cytokine and Chemokine Responses.
Nathella Pavan Kumar,V V Banurekha,Girish Kumar C P,Arul Nancy,Chandrasekaran Padmapriyadarsini,A Stella Mary,K. R. Uma Devi,Manoj V Murhekar,Subash Babu +8 more
TL;DR: In this article, the effect of prime-boost vaccination with Covaxin on systemic immune responses was investigated and it was shown that the effect on the plasma levels of a wide panel of cytokines and chemokines at baseline (M0) and at months 1 (M1), 2 (M2) and 3 (M3) following primeboost vaccination in healthy volunteers.
Journal ArticleDOI
Interplay of Immunosuppression and Immunotherapy Among Patients With Cancer and COVID-19.
Ziad Bakouny,Chris Labaki,Punita Grover,Joy Awosika,Shuchi Gulati,Chih-Yuan Hsu,Saif Alimohamed,Babar Bashir,Stephanie Berg,Mehmet Asim Bilen,Daniel W. Bowles,Cecilia A. Castellano,Aakash Desai,Arielle Elkrief,Omar Eton,Leslie A. Fecher,Daniel Blake Flora,Matthew D. Galsky,Margaret E. Gatti-Mays,Alicia Gesenhues,Michael Glover,Dharmesh Gopalakrishnan,Shilpa Gupta,Thorvardur R. Halfdanarson,Brandon Hayes-Lattin,Mohamed Hendawi,Emily Hsu,Clara Hwang,Roman Jandarov,Chinmay Jani,Douglas B. Johnson,Monika Joshi,Hina Khan,Shaheer Khan,N Knox,Vadim S. Koshkin,Amit A. Kulkarni,Daniel Kwon,Sara Matar,Rana R. McKay,Sanjay Mishra,Feras Aymen Moria,Amanda Nizam,Nora L. Nock,Taylor K. Nonato,Justin Panasci,Lauren D. Pomerantz,Andrew J. Portuguese,Destie Provenzano,Matthew Puc,Yuan James Rao,Terence Duane Rhodes,Gregory J. Riely,Jacob J Ripp,Andrea V. Rivera,Erika Ruiz-García,Andrew Schmidt,Adam J. Schoenfeld,Gary K. Schwartz,Sumit A. Shah,Justin Shaya,Suki Subbiah,Lisa May Ling Tachiki,Matthew D Tucker,Melissa Valdez-Reyes,Lisa Weissmann,Michael Wotman,Elizabeth Marie Wulff-Burchfield,Zhuoer Xie,Yuanchu J Yang,M. A. Thomson,Dimpy P. Shah,Jeremy L. Warner,Yu Shyr,Toni K. Choueiri,Trisha Wise-Draper +75 more
TL;DR: In this paper , the authors investigated the association of baseline immunosuppression and/or IO-based therapies with COVID-19 severity and cytokine storm in patients with cancer.
Journal ArticleDOI
High Titers of Low Affinity Antibodies in COVID-19 Patients Are Associated With Disease Severity
Jan Hendriks,Richard B.M. Schasfoort,Michelle Koerselman,M. J. Dannenberg,Alexander D. Cornet,Albertus Beishuizen,J. G. P. Van Der Palen,Johannes G. Krabbe,A. H. L. Mulder,Marcel Karperien +9 more
TL;DR: In critically ill patients, antibody production is high, but affinity is low, and maturation is impaired, which may play a role in disease exacerbation and could be valuable as a prognostic marker for predicting severity.
Journal ArticleDOI
Albumin protects the liver from tumor necrosis factor α-induced immunopathology
Marta Duran-Güell,Roger Flores-Costa,Mireia Casulleras,Cristina López-Vicario,Esther Titos,Alba Díaz,José Alcaraz-Quiles,Raquel Horrillo,Montserrat Costa,Javier Fernández,Vicente Arroyo,Joan Clària +11 more
TL;DR: In this article, the authors investigated whether albumin also has the ability to protect tissues from the damaging actions of these inflammatory mediators, and they circumscribed their investigation to tumor necrosis factor (TNF) α, which exemplifies the connection between immunity and tissue injury.
References
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Gout-associated uric acid crystals activate the NALP3 inflammasome
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