Cytokine Storm.
David C. Fajgenbaum,Carl H. June +1 more
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From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory, and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia.Abstract:
From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory (D.C.F.), and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy (C.H.J.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. Address reprint requests to Dr. Fajgenbaum at davidfa@ pennmedicine . upenn . edu or to Dr. June at cjune@ upenn . edu.read more
Citations
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Long COVID: a narrative review of the clinical aftermaths of COVID-19 with a focus on the putative pathophysiology and aspects of physical activity
S. Haunhorst,Wilhelm Bloch,Heiko Wagner,Claudia Ellert,Karsten Krüger,D Vilser,Kathrin Finke,Philipp A. Reuken,Mathias W. Pletz,Andreas Stallmach,Christian Puta +10 more
TL;DR: Different aspects of Long COVID are explored and the literature on what is known about its clinical manifestations, potential pathophysiological mechanisms, and treatment options are mapped.
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Cytokine adsorption during ECMO for COVID-19-related ARDS.
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COVID-19: The Impact on Cardiovascular System.
Jozica Šikić,Zrinka Planinić,Vid Matišić,Tea Friščić,Vilim Molnar,Dorijan Jagačić,Lovro Vujičić,Neven Tudorić,Lana Postružin Gršić,Đivo Ljubičić,Dragan Primorac +10 more
TL;DR: In this article, the authors reviewed the available literature on cardiovascular implications of COVID-19; both the acute and the chronic, and provided evidence-based medicine principles to the attending clinicians in order to provide fast and reliable treatment to their patients.
Journal ArticleDOI
Anemia in diabetes mellitus in Africa: A systematic review and meta-analysis
Ronald Olum,Felix Bongomin,Mark Mohan Kaggwa,Irene Andia-Biraro,Irene Andia-Biraro,Joseph Baruch Baluku +5 more
TL;DR: In this paper, a systematic review and meta-analysis was conducted to estimate the prevalence of anemia among people with diabetes mellitus in Africa, and the pooled prevalence was 35% (95% CI: 28%−42%, I2 = 97.7%).
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Insights into pandemic respiratory viruses: manipulation of the antiviral interferon response by SARS-CoV-2 and influenza A virus
GuanQun Liu,Michaela U. Gack +1 more
TL;DR: In this paper , the authors summarize the growing knowledge about the interplay of SARS-CoV-2 and antiviral innate immunity, with an emphasis on the regulation of type-I or -III interferon responses that are critically implicated in COVID-19 pathogenesis.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
Tim R. Mosmann,R L Coffman +1 more
TL;DR: Two types of cloned helper T cells are described, defined primarily by differences in the pattern of lymphokines ynthesized, and the different functions of the two types of cells and their lymphokine synthesis are discussed.
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From inflammation to sickness and depression: when the immune system subjugates the brain
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IL-17 and Th17 Cells.
TL;DR: The investigation of the differentiation, effector function, and regulation of Th17 cells has opened up a new framework for understanding T cell differentiation and now appreciate the importance of Th 17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease.
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Gout-associated uric acid crystals activate the NALP3 inflammasome
TL;DR: It is shown that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1β and IL-18 in mice deficient in the IL-1β receptor.
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