Cytokine Storm.
David C. Fajgenbaum,Carl H. June +1 more
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From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory, and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia.Abstract:
From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory (D.C.F.), and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy (C.H.J.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. Address reprint requests to Dr. Fajgenbaum at davidfa@ pennmedicine . upenn . edu or to Dr. June at cjune@ upenn . edu.read more
Citations
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Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19
Xixi Jing,Min Xu,Deye Song,Tingting Yue,Yali Wang,Pan Zhang,Yanjun Zhang,Min Zhang,Tommy Tsan-Yuk Lam,Nuno R. Faria,Erik De Clercq,Guang-qi Li +11 more
TL;DR: In this paper , the early responses of inflammatory cytokines would lead to high or low titers of anti-SARS-CoV-2 antibodies in COVID-19 patients.
Journal ArticleDOI
Comparison of the Characteristics of Cytokine Storm and Immune Response Induced by SARS-CoV, MERS-CoV, and SARS-CoV-2 Infections.
TL;DR: In this article, the authors compared the characters of cytokine storms and immune responses caused by three highly pathogenic and infectious coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome-coronavirus(MERS)-CoV, and severe Acute Respiratory Syndrome Coronavirus 2(SARS -CoV-2), and analyzes the possible mechanisms to guide clinical treatment in the future.
Journal ArticleDOI
Pathophysiology of The Acute Respiratory Distress Syndrome: Insights from Clinical Studies
Pratik Sinha,Lieuwe D. J. Bos +1 more
TL;DR: In this article, some of the key advances made in our knowledge of the pathophysiology of acute respiratory distress syndrome (ARDS) based on histopathology, imaging, protein, and transcriptomic biomarkers are presented.
Journal ArticleDOI
The heterogeneous landscape and early evolution of pathogen-associated CpG dinucleotides in SARS-CoV-2.
Andrea Di Gioacchino,Petr Šulc,Anastassia V. Komarova,Benjamin D. Greenbaum,Rémi Monasson,Simona Cocco +5 more
TL;DR: In this article, the distribution of CpG dinucleotides, a pathogen-associated molecular pattern, in the SARS-CoV-2 genome was analyzed.
Journal ArticleDOI
Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors
TL;DR: In this article, the authors discuss the diverse spectrum of cardiovascular toxicities associated with immune checkpoint inhibitors (ICI) and provide insight and future directions on mechanisms and treatments for immune-related adverse events (irAEs) involving the myocardium, pericardium, vasculature, and conduction system.
References
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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
Tim R. Mosmann,R L Coffman +1 more
TL;DR: Two types of cloned helper T cells are described, defined primarily by differences in the pattern of lymphokines ynthesized, and the different functions of the two types of cells and their lymphokine synthesis are discussed.
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Gout-associated uric acid crystals activate the NALP3 inflammasome
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