Cytokine Storm.
David C. Fajgenbaum,Carl H. June +1 more
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From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory, and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia.Abstract:
From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory (D.C.F.), and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy (C.H.J.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. Address reprint requests to Dr. Fajgenbaum at davidfa@ pennmedicine . upenn . edu or to Dr. June at cjune@ upenn . edu.read more
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Potential use of serum-derived bovine immunoglobulin/protein isolate for the management of COVID-19.
Netanya S. Utay,David M. Asmuth,Shahin Gharakhanian,Moises Contreras,Christopher D. Warner,Christopher J. Detzel +5 more
TL;DR: Serum derived bovine immunoglobulin/protein isolate (SBI) as discussed by the authors was used to prevent the cytokine storm in colorectal cancer patients by binding and neutralizing inflammatory antigens, decreasing intestinal permeability, interfering with ACE2 binding by viral proteins, and improving the fecal microbiome.
Journal ArticleDOI
Phenotypic PIA-Dependent Biofilm Production by Clinical Non-Typeable Staphylococcus aureus Is Not Associated with the Intensity of Inflammation in Mammary Gland: A Pilot Study Using Mouse Mastitis Model.
Jully Gogoi-Tiwari,Dorji Dorji,Harish Kumar Tiwari,Gayatri D Shirolkar,J.W. Aleri,Trilochan Mukkur +5 more
TL;DR: In this article, the authors investigated the impact of biofilm formation by clinical Staphylococcus aureus on cytokine production and mammary tissue damage by using a mouse mastitis model.
Journal ArticleDOI
Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis
Alba Grifoni,Tonino Alonzi,Galit Alter,Douglas M. Noonan,Alan L. Landay,Adriana Albini,Delia Goletti +6 more
TL;DR: In this paper , a review of the recent understanding of age-related changes affecting key components of immunity is presented, focusing on immunosenescence and inflammaging that are impacted by common infectious diseases that are characterized by a high mortality, and includes COVID-19, HIV and tuberculosis.
Journal ArticleDOI
Diffuse interstitial pneumonia-like/macrophage activation syndrome-like changes in patients with COVID-19 correlate with length of illness.
Juan C. Felix,Yuri Sheinin,David Suster,Natali Ronen,Mariam Ratiani,Tana Vanden Heuvel,Emilie Winge,Mollie Patton,Mary J. Rau,Linna Ge,Yunguang Sun,Sameer S Udhane,John F. Langenheim,Hallgeir Rui +13 more
TL;DR: In this paper, the pathologic changes in the lungs of COVID-19 decedents and correlate these changes with demographic data, clinical course, therapies, and duration of illness.
Journal ArticleDOI
Alterations in levels of cytokine following treatment to predict outcome of sepsis: A meta-analysis.
TL;DR: In this article , the authors investigated the relationship between changes in cytokine levels after treatment compared with those on hospital admission, and their relationship with the prognosis of patients with sepsis.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
Tim R. Mosmann,R L Coffman +1 more
TL;DR: Two types of cloned helper T cells are described, defined primarily by differences in the pattern of lymphokines ynthesized, and the different functions of the two types of cells and their lymphokine synthesis are discussed.
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From inflammation to sickness and depression: when the immune system subjugates the brain
TL;DR: In response to a peripheral infection, innate immune cells produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour, which can lead to an exacerbation of sickness and the development of symptoms of depression in vulnerable individuals.
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IL-17 and Th17 Cells.
TL;DR: The investigation of the differentiation, effector function, and regulation of Th17 cells has opened up a new framework for understanding T cell differentiation and now appreciate the importance of Th 17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease.
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Gout-associated uric acid crystals activate the NALP3 inflammasome
TL;DR: It is shown that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1β and IL-18 in mice deficient in the IL-1β receptor.
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