Cytokine Storm.
David C. Fajgenbaum,Carl H. June +1 more
Reads0
Chats0
TLDR
From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory, and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia.Abstract:
From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory (D.C.F.), and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy (C.H.J.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. Address reprint requests to Dr. Fajgenbaum at davidfa@ pennmedicine . upenn . edu or to Dr. June at cjune@ upenn . edu.read more
Citations
More filters
Journal ArticleDOI
Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.
TL;DR: In this paper, the authors evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform trial, which used a Bayesian statistical model with predefined criteria for superiority, efficacy, equivalence or futility.
Journal ArticleDOI
Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19.
Aldo Bonaventura,Aldo Bonaventura,Alessandra Vecchié,Lorenzo Dagna,Kimberly Martinod,Dave L. Dixon,Benjamin W. Van Tassell,Francesco Dentali,Fabrizio Montecucco,Steffen Massberg,Marcel Levi,Antonio Abbate +11 more
TL;DR: In this paper, the authors proposed that SARS-CoV-2 infection induces a process known as immunothrombosis, in which activated neutrophils and monocytes interact with platelets and the coagulation cascade, leading to intravascular clot formation in small and larger vessels.
Journal ArticleDOI
COVID-19 and the human innate immune system.
TL;DR: In this article, a conceptual framework for the interaction of the human innate immune system with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was provided to link the clinical observations with experimental findings that have been made during the first year of the pandemic.
Journal ArticleDOI
Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia.
Patrícia O. Guimarães,Daniel Quirk,Remo H. Furtado,Lilia N. Maia,José F. Saraiva,Murillo Oliveira Antunes,Roberto Kalil Filho,Vagner Madrini Junior,Alexandre de Matos Soeiro,Alexandre P. Tognon,Viviane C Veiga,Priscilla de Aquino Martins,Diogo D.F. Moia,Bruna S. Sampaio,Silvia R.L. Assis,Ronaldo V P Soares,Luciana P.A. Piano,Kleber Castilho,Roberta G.R.A.P. Momesso,Frederico Monfardini,Hélio Penna Guimarães,Dario Ponce de Leon,Majori Dulcine,Marcia Pinheiro,Levent M. Gunay,J. Jasper Deuring,Luiz Vicente Rizzo,Tamas Koncz,Otavio Berwanger +28 more
TL;DR: Among patients hospitalized with Covid-19 pneumonia, tofacitinib led to a lower risk of death or respiratory failure through day 28 than placebo, and the proportional odds of having a worse score on the eight-level ordinal scale with tofacinib, as compared with placebo.
Journal ArticleDOI
The signal pathways and treatment of cytokine storm in COVID-19.
TL;DR: In this paper, the authors discuss the latest developments in the immunopathological characteristics of COVID-19 and focus on CS including the current research status of the different cytokines involved, and discuss the induction, function, downstream signaling and existing and potential interventions for targeting these cytokines or related signal pathways.
References
More filters
Journal ArticleDOI
Impaired natural killer activity in lymphohistiocytosis syndrome
Nestor Perez,Jean-Louis Virelizier,Fernando Arenzana-Seisdedos,Alain Fischer,Claude Griscelli +4 more
TL;DR: The findings indicate that testing NK activity is useful for the diagnosis of lymphohistiocytosis syndrome and can be used as an index of activity of the disease, among other major clinical and biologic signs of this syndrome.
Journal ArticleDOI
Hyperinduction of Cyclooxygenase-2-Mediated Proinflammatory Cascade: A Mechanism for the Pathogenesis of Avian Influenza H5N1 Infection
Suki M. Y. Lee,CY Cheung,John M. Nicholls,Kenrie P Y Hui,Connie Y. H. Leung,Mongkol Uiprasertkul,George L. Tipoe,Yu-Lung Lau,Leo L.M. Poon,Nancy Y. Ip,Yi Guan,J. S. Malik Peiris +11 more
TL;DR: It is revealed that cyclooxygenase-2 (COX-2) was strongly induced in H5N1-infected macrophages in vitro and in epithelial cells of lung tissue samples obtained during autopsy of patients who died of H5n1 disease.
Journal ArticleDOI
Protection against lethal bacterial infection in mice by monocyte-chemotactic and -activating factor.
TL;DR: In vivo effect on the survival of mice paralleled the reduced recovery of viable P. aeruginosa or S. typhimurium from the peritoneal cavity, since MCAF exhibited chemotaxis on murine macrophages as well as enhanced phagocytosis and killing of bacteria in vitro, is responsible for eliminating bacteria and thus enhancing the survival rate.
Journal ArticleDOI
The Mechanism of Superantigen-Mediated Toxic Shock: Not a Simple Th1 Cytokine Storm
TL;DR: The results demonstrate unequivocally that TCRαβ T cells are critical for lethality in toxic shock but it is the early TNF-α response and not the later cytokine surge that mediates lethal shock.
Journal ArticleDOI
Preclinical In Vivo Modeling of Cytokine Release Syndrome Induced by ErbB-Retargeted Human T Cells: Identifying a Window of Therapeutic Opportunity?
Sjoukje J. C. van der Stegen,David M. Davies,Scott Wilkie,Julie Foster,Jane K. Sosabowski,Jerome Burnet,Lynsey M. Whilding,Roseanna Maria Petrovic,Sadaf Ghaem-Maghami,Stephen J. Mather,Jean-Pierre Jeannon,Jean-Pierre Jeannon,Ana C. Parente-Pereira,John Maher,John Maher,John Maher +15 more
TL;DR: These data demonstrate that CAR-induced cytokine release syndrome can be modeled in mice that express target Ag in an appropriate distribution, and argue that ErbB-retargeted T cells can achieve therapeutic benefit in the absence of unacceptable toxicity, providing that route of administration and dose are carefully optimized.
Related Papers (5)
Dexamethasone in Hospitalized Patients with Covid-19
Peter Horby,Wei Shen Lim,Jonathan Emberson,M Mafham,Jennifer L Bell,Louise Linsell,Natalie Staplin,Christopher E. Brightling,Andrew Ustianowski,E Elmahi,B Prudon,Christopher A Green,Timothy Felton,David Chadwick,K Rege,C Fegan,Lucy C Chappell,Saul N. Faust,Thomas Jaki,Katie Jeffery,Alan A Montgomery,Kathryn M Rowan,Edmund Juszczak,J K Baillie,Richard Haynes,Martin J Landray +25 more
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more