scispace - formally typeset
Open AccessJournal ArticleDOI

Cytokine Storm.

David C. Fajgenbaum, +1 more
- 03 Dec 2020 - 
- Vol. 383, Iss: 23, pp 2255-2273
Reads0
Chats0
TLDR
From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory, and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia.
Abstract: 
From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory (D.C.F.), and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy (C.H.J.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. Address reprint requests to Dr. Fajgenbaum at davidfa@ pennmedicine . upenn . edu or to Dr. June at cjune@ upenn . edu.

read more

Content maybe subject to copyright    Report

Citations
More filters
Journal ArticleDOI

An Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome

M. Taylor, +30 more
- 15 Jul 2022 - 
TL;DR: Clinical outcomes in children with hemophagocytic lymphohistiocytosis and macrophage activation syndrome who were managed before and after implementation of an evidence-based guideline (EBG) suggest that a multidisciplinary treatment pathway for MAS-HLH contributed meaningfully to favorable patient outcomes.
Journal ArticleDOI

Association between polymorphisms of cytokine genes and diabetic nephropathy: A comprehensive systematic review and meta-analysis.

Jinwen Wu, +4 more
- 08 Aug 2021 - 
TL;DR: In this article, a structured bibliographic search on PubMed, Scopus, and EMBASE databases has been performed to identify related papers to investigate the cytokine gene polymorphisms association with diabetic nephropathy.
Journal ArticleDOI

Current Therapeutics for COVID-19, What We Know about the Molecular Mechanism and Efficacy of Treatments for This Novel Virus

Divya Narayanan, +1 more
- 01 Jul 2022 - 
TL;DR: This review focuses on currently used therapies in the United States and discusses the molecular mechanisms by which these therapies target the SARS-CoV-2 virus or the COVID-19 disease process, and the evolution of data surrounding the efficacy of these therapies.
Journal ArticleDOI

Case report: A rare case of Rosai–Dorfman–Destombes disease after the COVID-19 infection

Pooja Gogia, +4 more
- 19 Dec 2022 - 
TL;DR: A 55-year-old Asian-American woman with no significant medical history or recent use of new drugs initially presented with cervical lymphadenopathy and urticarial rash 1 week after receiving the COVID-19 messenger RNA (mRNA) vaccine (Moderna, mRNA-1273) against SARS-CoV-2 as mentioned in this paper .
Journal ArticleDOI

Dermatologic adverse events associated with IDH inhibitors ivosidenib and enasidenib for the treatment of acute myeloid leukemia.

Rose Parisi, +7 more
- 01 Oct 2022 - 
TL;DR: In this paper , the authors performed a retrospective analysis of 169 patients who were treated with either ivosidenib or enasidenib as single agent or in combination with induction chemotherapy at Memorial Sloan Kettering Cancer Center from January 1, 2013 to April 1, 2021.
References
More filters
Journal ArticleDOI

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang, +28 more
- 24 Jan 2020 - 
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.

Tim R. Mosmann, +1 more
- 01 Jan 1989 - 
TL;DR: Two types of cloned helper T cells are described, defined primarily by differences in the pattern of lymphokines ynthesized, and the different functions of the two types of cells and their lymphokine synthesis are discussed.
Journal ArticleDOI

From inflammation to sickness and depression: when the immune system subjugates the brain

Robert Dantzer, +4 more
- 01 Jan 2008 - 
TL;DR: In response to a peripheral infection, innate immune cells produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour, which can lead to an exacerbation of sickness and the development of symptoms of depression in vulnerable individuals.
Journal ArticleDOI

IL-17 and Th17 Cells.

Thomas Korn, +3 more
- 20 Mar 2009 - 
TL;DR: The investigation of the differentiation, effector function, and regulation of Th17 cells has opened up a new framework for understanding T cell differentiation and now appreciate the importance of Th 17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease.
Journal ArticleDOI

Gout-associated uric acid crystals activate the NALP3 inflammasome

Fabio Martinon, +4 more
- 09 Mar 2006 - 
TL;DR: It is shown that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1β and IL-18 in mice deficient in the IL-1β receptor.
Related Papers (5)

Dexamethasone in Hospitalized Patients with Covid-19

Peter Horby, +25 more
- 17 Jul 2020 - 

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang, +28 more
- 24 Jan 2020 - 

COVID-19: consider cytokine storm syndromes and immunosuppression

Puja Mehta, +6 more
- 28 Mar 2020 - 

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.

Fei Zhou, +19 more
- 28 Mar 2020 - 

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann, +13 more
- 16 Apr 2020 -