Cytokine Storm.
David C. Fajgenbaum,Carl H. June +1 more
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From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory, and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia.Abstract:
From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory (D.C.F.), and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy (C.H.J.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. Address reprint requests to Dr. Fajgenbaum at davidfa@ pennmedicine . upenn . edu or to Dr. June at cjune@ upenn . edu.read more
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MXene-Based Aptasensors: Advances, Challenges, and Prospects
Qurat ul Ain Zahra,S. Ullah,Faisal Shahzad,Ben Jun Qiu,Xiaona Fang,Ayesha Ammar,Zhaofeng Luo,Shabi Abbas Zaidi +7 more
TL;DR: The combination of 2D MXenes with high affinity aptamers has resulted in the development of innovative aptasensing approaches for food/water safety and clinical diagnosis as discussed by the authors , where the authors address sensing platforms for the identification of several types of cancers, mycotoxins, and other analytes.
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Autoantibodies in COVID‐19 correlate with antiviral humoral responses and distinct immune signatures
Patricia Taeschler,Carlo Cervia,Yves Zurbuchen,Sara Hasler,Christian Pou,Zi Yan Tan,Sarah Adamo,Miro E. Raeber,E. B. Bächli,Alain Rudiger,Melina Stüssi-Helbling,Lars C. Huber,Petter Brodin,Jakob Nilsson,Elsbeth Probst-Müller,Onur Boyman +15 more
TL;DR: This study longitudinally screened for clinically relevant systemic autoantibodies to assess their prevalence, temporal trajectory, and association with immunity, comorbidities, and severity of COVID‐19.
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Hypoxia-inducible factor (HIF): The link between obesity and COVID-19.
Antoine Fakhry AbdelMassih,Elaria Yacoub,Reem J. Husseiny,Aya Kamel,Rafeef Hozaien,Meryam El Shershaby,Maram Rajab,Shenoda Yacoub,Maryam A. Eid,Maryam Elahmady,Mahenar Gadalla,Sherouk Mokhtar,Alaa A. Hassan,Aya S. Abou-Zeid,Mahinour Hussein,Nour Aboushadi,Nadine Emad,Nihal Zahra,A. Hassan,Engy Hussein,Nourhan Ibrahim,Nadine El Nahhas,Tasneem Elahmady,Mohamed E. Khallaf,Hadeel Mustafa,Nancy Anis,Mirna Albehairy,Farid Hanna,Laila Moris,Jianping Ye +29 more
TL;DR: The discrepancy of manifestations seen in COVID-19 seems to be mediated by a differential immune response rather than a differential viral load, which can directly correlate the effect of a hypoxic environment with the increase of HIF-1α level as mentioned in this paper.
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Daily monitoring of viral load measured as SARS-CoV-2 antigen and RNA in blood, IL-6, CRP and complement C3d predicts outcome in patients hospitalized with COVID-19.
Claus Lohman Brasen,Henry Christensen,Dorte Aalund Olsen,Søren Kahns,Rikke Fredslund Andersen,Jeppe B. Madsen,Amanda Lassen,Helene Kierkegaard,Anders A. Jensen,Thomas Vognbjerg Sydenham,Jonna Skov Madsen,Jens Kjølseth Møller,Ivan Brandslund +12 more
TL;DR: In this paper, the amount of antigen produced in the body during a COVID-19 infection might differ between patients, and that maximum concentrations would predict the degree of both inflammation and outcome for patients.
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Next-Generation CAR T-cell Therapies
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References
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Gout-associated uric acid crystals activate the NALP3 inflammasome
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