Differential Behaviors of Atrial Versus Ventricular Fibroblasts A Potential Role for Platelet-Derived Growth Factor in Atrial-Ventricular Remodeling Differences
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TLDR
Atrial fibroblasts behave differently than ventricular fibro Blasts over a range of in vitro and in vivo paradigms, with atrial Fibroblast showing enhanced reactivity that may explain greater atrial fibrotic responses.Abstract:
Background— In various heart disease paradigms, atria show stronger fibrotic responses than ventricles. The possibility that atrial and ventricular fibroblasts respond differentially to pathological stimuli has not been examined. Methods and Results— We compared various morphological, secretory, and proliferative response indexes of canine atrial versus ventricular fibroblasts. Cultured atrial fibroblasts showed faster cell surface area increases, distinct morphology at confluence, and greater α-smooth muscle actin expression than ventricular fibroblasts. Atrial fibroblast proliferation ([3H]thymidine incorporation) responses were consistently greater for a range of growth factors, including fetal bovine serum, platelet-derived growth factor (PDGF), basic fibroblast growth factor, angiotensin II, endothelin-1, and transforming growth factor-β1. Normal atrial tissue showed larger myofibroblast density compared with ventricular tissue, and the difference was exaggerated by congestive heart failure. Congesti...read more
Citations
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Atrial Fibrillation in Primary Aldosteronism
Chien-Ting Pan,Cheng-Hsuan Tsai,Zheng-Wei Chen,Yi-Yao Chang,Vin-Cent Wu,Chi-Sheng Hung,Yen-Hung Lin +6 more
TL;DR: The current evidence of the relationship between PA and AF is outlined, recent progress in the management of PA is highlighted, and the results of medical treatment with mineralocorticoid receptor antagonists (MRAs) have been inconsistent.
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A temporal window of vulnerability for development of atrial fibrillation with advancing heart failure.
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TL;DR: The present study was designed to determine the time‐course of development of electrical and structural remodelling of the atria and ventricles, and their contribution to induction of AF and VT/VF in a canine model of HF.
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The degree of left atrial structural remodeling impacts left ventricular ejection fraction in patients with atrial fibrillation.
Mehmet Akkaya,Nassir F. Marrouche,Koji Higuchi,Matthias Koopmann,Kavitha Damal,Eugene G. Kholmovski,Christopher J. McGann +6 more
TL;DR: Patients with extensive LA fibrosis appear to have depressed LV function pre-ablation, suggesting that structural remodeling in the LA may also be triggering and promoting remodeling within the ventricular myocardium.
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Cardiac gene expression profiling – the quest for an atrium-specific biomarker
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TL;DR: In this paper, an approach was described to identify genes preferably expressed in atrial cardiomyocytes compared with ventricular cells by RNA microarray and confirmed by quantitative real-time polymerase chain reaction.
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Sodium tanshinone IIA sulfonate attenuates the transforming growth factor-β1-induced differentiation of atrial fibroblasts into myofibroblasts in vitro.
TL;DR: It is demonstrated that sodium tanshinone IIA sulfonate exerts antifibrotic effects by modulating atrial fibroblast differentiation through ERK phosphorylation and the Smad pathway.
References
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