Journal ArticleDOI
Down-regulation of the miRNA master regulators Drosha and Dicer is associated with specific subgroups of breast cancer
Konstantin J. Dedes,Rachael Natrajan,Maryou B K Lambros,Felipe C. Geyer,María Ángeles López-García,María Ángeles López-García,Kay Savage,Robin L. Jones,Jorge S. Reis-Filho +8 more
TLDR
The results suggest that down-regulation of Drosha and/or Dicer is not robustly associated with the outcome of breast cancer patients treated with adjuvant anthracycline-based chemotherapy but preferentially observed in distinct subgroups of breast cancers.About:
This article is published in European Journal of Cancer.The article was published on 2011-01-01. It has received 147 citations till now. The article focuses on the topics: Drosha & Dicer.read more
Citations
More filters
Journal ArticleDOI
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
TL;DR: Recent advances in the understanding of miRNAs in cancer and in other diseases are described and the challenge of identifying the most efficacious therapeutic candidates is discussed and a perspective on achieving safe and targeted delivery of miRNA therapeutics is provided.
Journal ArticleDOI
MicroRNA biogenesis pathways in cancer
Shuibin Lin,Richard I. Gregory +1 more
TL;DR: Global miRNA depletion caused by genetic and epigenetic alterations in components of the miRNA biogenesis machinery is oncogenic, highlighting the importance of miRNA dysregulation in cancer.
Journal ArticleDOI
MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer.
TL;DR: The role of microRNAs in the diagnosis, prognosis, and therapy of breast cancer is discussed in this paper, where the authors present the state-of-the-art on the role of miRNAs.
Journal ArticleDOI
miRNA Deregulation in Cancer Cells and the Tumor Microenvironment
TL;DR: Insight is provided into the regulatory mechanisms involved in the deregulation of miRNAs in cancer cells and the tumor microenvironment and therapeutic intervention strategies to overcome this deregulation are discussed.
Journal ArticleDOI
DICER1: mutations, microRNAs and mechanisms
TL;DR: This Review reflects on the molecular properties of the Dicer enzymes in small RNA silencing pathways, and rationalizes the newly discovered mutations on the basis of the activities and functions of its determinants.
References
More filters
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal Article
Oncomirs : microRNAs with a role in cancer
TL;DR: I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.
Journal ArticleDOI
A microRNA expression signature of human solid tumors defines cancer gene targets
Stefano Volinia,George A. Calin,Chang Gong Liu,Stefan Ambs,Amelia Cimmino,Fabio Petrocca,Rosa Visone,Marilena V. Iorio,Claudia Roldo,Manuela Ferracin,Robyn L. Prueitt,Nozumu Yanaihara,Giovanni Lanza,Aldo Scarpa,Andrea Vecchione,Massimo Negrini,Curtis C. Harris,Carlo M. Croce +17 more
TL;DR: The results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes.
Journal ArticleDOI
Oncomirs — microRNAs with a role in cancer
TL;DR: Evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes.
Journal ArticleDOI
Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up.
C. W. Elston,Ian O. Ellis +1 more
TL;DR: The results demonstrate that this method for histological grading provides important prognostic information and, if the grading protocol is followed consistently, reproducible results can be obtained.
Related Papers (5)
Dicer, Drosha, and outcomes in patients with ovarian cancer
William M. Merritt,Yvonne G. Lin,Liz Y. Han,Aparna A. Kamat,Whitney A. Spannuth,Rosemarie Schmandt,Diana L. Urbauer,Len A. Pennacchio,Len A. Pennacchio,Jan Fang Cheng,Jan Fang Cheng,Alpa M. Nick,Michael T. Deavers,Alexandra A. Mourad-Zeidan,Hua Wang,Peter R. Mueller,Marc E. Lenburg,Joe W. Gray,Samuel C. Mok,Michael J. Birrer,Gabriel Lopez-Berestein,Robert L. Coleman,Menashe Bar-Eli,Anil K. Sood +23 more
MicroRNA gene expression deregulation in human breast cancer.
Marilena V. Iorio,Manuela Ferracin,Chang Gong Liu,Angelo Veronese,Riccardo Spizzo,Silvia Sabbioni,Eros Magri,Massimo Pedriali,Muller Fabbri,Manuela Campiglio,Sylvie Ménard,Juan P. Palazzo,Anne L. Rosenberg,Piero Musiani,Stefano Volinia,Italo Nenci,George A. Calin,Patrizia Querzoli,Massimo Negrini,Carlo M. Croce +19 more