Effectiveness of Rotavirus Vaccination: A Systematic Review of the First Decade of Global Postlicensure Data, 2006-2016.
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Postlicensure data from countries across geographic regions and with different child mortality levels demonstrate that under routine use, both RV1 and RV5 are effective against rotav virus disease, supporting the World Health Organization recommendation that all countries introduce rotavirus vaccine into their national immunization program.Abstract:
Two rotavirus vaccines, Rotarix (RV1) and RotaTeq (RV5), were licensed for global use in 2006. A systematic review of 48 peer- reviewed articles with postlicensure data from 24 countries showed a median RV1 vaccine effectiveness (VE) of 84%, 75%, and 57% in countries with low, medium, and high child mortality, respectively, and RV5 VE of 90% and 45% in countries with low and high child mortality, respectively. A partial vaccine series provided considerable protection, but not to the same level as a full series. VE tended to decline in the second year of life, particularly in medium- and high-mortality settings, and tended to be greater against more severe rotavirus disease. Postlicensure data from countries across geographic regions and with different child mortality levels demonstrate that under routine use, both RV1 and RV5 are effective against rotavirus disease, supporting the World Health Organization recommendation that all countries introduce rotavirus vaccine into their national immunization program.read more
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Reference EntryDOI
Vaccines for preventing rotavirus diarrhoea: vaccines in use
Karla Soares-Weiser,Harriet MacLehose,Hanna Bergman,Irit Ben-Aharon,Sukrti Nagpal,Elad Goldberg,Femi Pitan,Nigel A. Cunliffe +7 more
TL;DR: Evaluating rotavirus vaccines approved for use (RV1, RV5, and LLR) for preventingRotavirus diarrhoea in children with high-mortality rates found that RV1 probably prevents 40% of severe all-cause diarrhoeA episodes, and RV5probably prevents 40%, based on one large multicentre trial in Latin America and Finland.
Journal ArticleDOI
Global impact of rotavirus vaccine introduction on rotavirus hospitalisations among children under 5 years of age, 2008-16: findings from the Global Rotavirus Surveillance Network.
Negar Aliabadi,Sebastien Antoni,Jason M. Mwenda,Goitom Weldegebriel,Joseph Nsiari-Muzeyi Biey,Dah Cheikh,Kamal Fahmy,Nadia Teleb,Hossam Ashmony,Hinda Ahmed,Danni S. Daniels,Dovile Videbaek,Annemarie Wasley,Simarjit Singh,Lucia Helena de Oliveira,Gloria Rey-Benito,N Jennifer Sanwogou,Pushpa Ranjan Wijesinghe,Jayantha B. L. Liyanage,Batmunkh Nyambat,Varja Grabovac,James D. Heffelfinger,Kimberley Fox,Fem Julia Paladin,Tomoka Nakamura,Mary Agocs,Jillian Murray,Thomas Cherian,Catherine Yen,Umesh D. Parashar,Fatima Serhan,Jacqueline E. Tate,Adam L. Cohen +32 more
TL;DR: A significant and sustained reduction in the proportion of hospital admissions for acute gastroenteritis due to rotavirus was seen among children younger than 5 years in GRSN sites followingRotavirus vaccine introduction, highlighting the need to incorporate rotav virus vaccines into immunisation programmes in countries that have not yet introduced them and underline the importance of high-quality surveillance.
Journal ArticleDOI
Real-world effectiveness of rotavirus vaccines, 2006-19: a literature review and meta-analysis.
TL;DR: Rotavirus vaccines were effective in preventing rotavirus diarrhoea, with higher performance in countries with lower child mortality, and non-product-specific vaccination was similar for Rotarix and RotaTeq mixed series.
Journal ArticleDOI
Differences of Rotavirus Vaccine Effectiveness by Country: Likely Causes and Contributing Factors.
TL;DR: Various factors that have been identified or suggested as being involved in the differences of rotavirus vaccine effectiveness are reviewed here and recognition of these factors will help to achieve gradual worldwide improvement of rotvirusvaccine effectiveness.
Journal ArticleDOI
Effect of Antibiotic-Mediated Microbiome Modulation on Rotavirus Vaccine Immunogenicity: A Human, Randomized-Control Proof-of-Concept Trial.
Vanessa C. Harris,Bastiaan W. Haak,Scott A. Handley,Baoming Jiang,Daniel E. Velasquez,Barry L. Hykes,Lindsay Droit,Guy A.M. Berbers,E. M. Kemper,Ester M. M. van Leeuwen,Michael Boele van Hensbroek,Willem Joost Wiersinga +11 more
TL;DR: It is demonstrated that microbiota modification alters the immune response to RVV and supports further exploration of microbiome manipulation to improve RVV immunogenicity.
References
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Book
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Cochrane Handbook for Systematic Reviews of Interventions
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TL;DR: The tremendous incidence of rotavirus disease underscores the urgent need for interventions, such as vaccines, to prevent childhood deaths in developing nations.
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Safety and Efficacy of a Pentavalent Human–Bovine (WC3) Reassortant Rotavirus Vaccine
Timo Vesikari,David O. Matson,Penelope H. Dennehy,Pierre Van Damme,Mathuram Santosham,Zoe M. Rodriguez,Michael J. Dallas,Joseph F. Heyse,Michelle G. Goveia,Steven Black,Henry R. Shinefield,Celia D. C. Christie,Samuli Ylitalo,Robbin F. Itzler,Michele L. Coia,Matthew T. Onorato,Ben A. Adeyi,Gary S. Marshall,Leif Gothefors,Dirk Campens,Aino Karvonen,James P. Watt,Katherine L. O'Brien,Mark J. DiNubile,H Fred Clark,John W. Boslego,Paul A. Offit,Penny M. Heaton +27 more
TL;DR: This vaccine was efficacious in preventing rotavirus gastroenteritis, decreasing severe disease and health care contacts, and the risk of intussusception was similar in vaccine and placebo recipients.
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