Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA
Pan Wu,Pan Wu,Yongzhen Mo,Miao Peng,Ting Tang,Yu Zhong,Xiangying Deng,Fang Xiong,Can Guo,Xu Wu,Xu Wu,Yong Li,Xiaoling Li,Guiyuan Li,Guiyuan Li,Zhaoyang Zeng,Zhaoyang Zeng,Wei Xiong,Wei Xiong +18 more
Reads0
Chats0
TLDR
The aim of this review is to provide a theoretical basis and relevant references, which may promote the discovery of more functional peptides encoded by ncRNAs, and further develop novel anticancer therapeutic targets, as well as diagnostic and prognostic cancer markers.Citations
More filters
Journal ArticleDOI
Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy
TL;DR: The use of epi-drugs alone, or in combination with chemotherapy or immunotherapy, has shown compelling outcomes, including augmentation of anti-tumoral effects, overcoming drug resistance, and activation of host immune response.
Journal ArticleDOI
The role of microenvironment in tumor angiogenesis
Xianjie Jiang,Xianjie Jiang,Jie Wang,Xiangying Deng,Fang Xiong,Shanshan Zhang,Zhaojian Gong,Xiayu Li,Ke Cao,Hao Deng,Yi He,Qianjin Liao,Bo Xiang,Bo Xiang,Ming Zhou,Ming Zhou,Can Guo,Zhaoyang Zeng,Zhaoyang Zeng,Guiyuan Li,Guiyuan Li,Xiaoling Li,Xiaoling Li,Wei Xiong,Wei Xiong +24 more
TL;DR: The regulatory role of the microenvironment in tumor angiogenesis is discussed and high expression of angiogenic factors and inflammatory cytokines in the tumor microenvironment, as well as hypoxia, are presumed to be the reasons for poor therapeutic efficacy of current anti-angiogenic drugs.
Journal ArticleDOI
The small peptide world in long noncoding RNAs.
TL;DR: The methods of lncRNA classification, the investigations regarding their coding potential and the functional significance of the peptides they encode are discussed.
Journal ArticleDOI
Targeting circular RNAs as a therapeutic approach: current strategies and challenges
TL;DR: In this paper, a review of strategies that can be used to overexpress or knockdown circRNAs as a therapeutic approach is presented and major challenges and future directions for the development of circRNA-based therapeutics are discussed.
References
More filters
Journal ArticleDOI
MEGA7: Molecular Evolutionary Genetics Analysis version 7.0 for bigger datasets
TL;DR: The latest version of the Molecular Evolutionary Genetics Analysis (Mega) software, which contains many sophisticated methods and tools for phylogenomics and phylomedicine, has been optimized for use on 64-bit computing systems for analyzing larger datasets.
Journal ArticleDOI
Clustal W and Clustal X version 2.0
Mark A. Larkin,Gordon Blackshields,Nigel P. Brown,R. Chenna,Paul A. McGettigan,Hamish McWilliam,Franck Valentin,Iain M. Wallace,Andreas Wilm,Rodrigo Lopez,J.D. Thompson,Toby J. Gibson,Desmond G. Higgins +12 more
TL;DR: The Clustal W and ClUSTal X multiple sequence alignment programs have been completely rewritten in C++ to facilitate the further development of the alignment algorithms in the future and has allowed proper porting of the programs to the latest versions of Linux, Macintosh and Windows operating systems.
Journal ArticleDOI
An integrated encyclopedia of DNA elements in the human genome
TL;DR: The Encyclopedia of DNA Elements project provides new insights into the organization and regulation of the authors' genes and genome, and is an expansive resource of functional annotations for biomedical research.
Journal Article
An integrated encyclopedia of DNA elements in the human genome.
TL;DR: The Encyclopedia of DNA Elements project provides new insights into the organization and regulation of the authors' genes and genome, and is an expansive resource of functional annotations for biomedical research.
Journal ArticleDOI
UniProt: the Universal Protein knowledgebase
Rolf Apweiler,Amos Marc Bairoch,Cathy H. Wu,Winona C. Barker,Brigitte Boeckmann,Serenella Ferro,Elisabeth Gasteiger,Hongzhan Huang,Rodrigo Lopez,Michele Magrane,Maria Jesus Martin,Darren A. Natale,Claire O'Donovan,Nicole Redaschi,Lai-Su L. Yeh +14 more
TL;DR: The Swiss-Prot, TrEMBL and PIR protein database activities have united to form the Universal Protein Knowledgebase (UniProt), which is to provide a comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase, with extensive cross-references and query interfaces.