Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction.
TLDR
Emodin, an anthraquinone compound derived from genus Rheum and Polygonum, significantly blocked the S protein and ACE2 interaction in a dose-dependent manner and suggested that emodin may be considered as a potential lead therapeutic agent in the treatment of SARS.Citations
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Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2
Yadi Zhou,Yuan Hou,Jiayu Shen,Yin Huang,William R. Martin,Feixiong Cheng,Feixiong Cheng,Feixiong Cheng +7 more
TL;DR: This study presents an integrative, antiviral drug repurposing methodology implementing a systems pharmacology-based network medicine platform, quantifying the interplay between the HCoV–host interactome and drug targets in the human protein–protein interaction network.
Journal ArticleDOI
Potential Interventions for Novel Coronavirus in China: A Systematic Review
Lei Zhang,Yunhui Liu +1 more
TL;DR: It is suggested that all the potential interventions be implemented to control the emerging COVID‐19 if the infection is uncontrollable and the current children's RNA‐virus vaccines including influenza vaccine should be immunized for uninfected people and health care workers.
Journal ArticleDOI
COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives.
TL;DR: The interaction between the viral spike protein and angiotensin-converting enzyme 2, which triggers entry of the virus into host cells, is likely to be involved in the cardiovascular manifestations of COVID-19.
Journal ArticleDOI
COVID-19 diagnosis and management: a comprehensive review.
Giuseppe Pascarella,Alessandro Strumia,Chiara Piliego,Federica Bruno,Romualdo Del Buono,Fabio Costa,Simone Scarlata,Felice Eugenio Agrò +7 more
TL;DR: An overview of the known clinical features and treatment options for COVID‐19 is provided and quarantine is the only intervention that appears to be effective in decreasing the contagion rate.
Journal ArticleDOI
Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New Coronavirus (SARS-CoV-2): A Review and Perspective.
TL;DR: Clinical evidence showing the beneficial effect of TCM in the treatment of patients with SARS coronaviral infections are discussed and experiment studies that provide an insight into the mechanism underlying the therapeutic effect ofTCM are introduced.
References
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Journal ArticleDOI
Inhibition of Severe Acute Respiratory Syndrome Coronavirus Replication by Niclosamide
Chang Jer Wu,Jia Tsrong Jan,Chi Min Chen,Hsing Pang Hsieh,Der Ren Hwang,Hwan Wun Liu,Chiu Yi Liu,Hui Wen Huang,Su Chin Chen,Cheng Fong Hong,Ren Kuo Lin,Yu-Sheng Chao,John T.A. Hsu +12 more
TL;DR: Niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 μM, as revealed by immunoblot analysis.
Journal ArticleDOI
Membrane-related effects underlying the biological activity of the anthraquinones emodin and barbaloin.
TL;DR: A molecular mechanism based on the effect of these compounds on the structure of biological membranes is proposed to account for their multiple biological activities.
PatentDOI
Inhibition of SARS coronavirus infection with clinically approved antiviral drugs
TL;DR: In this paper, the authors proposed methods for treating or inhibiting SARS-CoV infection involving the administration of an interferon, particularly IFN α-n1, IFN β-1b, and human leukocyte IFNα or IFNβα.
Journal ArticleDOI
Structural Characterization of the SARS-Coronavirus Spike S Fusion Protein Core
Brian Tripet,Megan W. Howard,Michael G. Jobling,Randall K. Holmes,Kathryn V. Holmes,Robert S. Hodges +5 more
TL;DR: The biophysical analysis of the two predicted heptad repeat regions within the severe acute respiratory syndrome coronavirus S protein shows that in isolation the HR-N region forms a stable α-helical coiled coil that associates in a tetrameric state, which is consistent with the structures observed for other type 1 viral fusion proteins in their fusion-competent state.
Journal ArticleDOI
S Protein of Severe Acute Respiratory Syndrome-Associated Coronavirus Mediates Entry into Hepatoma Cell Lines and Is Targeted by Neutralizing Antibodies in Infected Patients
Heike Hofmann,Kim Hattermann,Andrea Marzi,Thomas Gramberg,Martina Geier,Mandy Krumbiegel,Seraphin Kuate,Klaus Überla,Matthias Niedrig,Stefan Pöhlmann +9 more
TL;DR: Evidence that SARS-CoV infection might not be limited to lung tissue and can be inhibited by the humoral immune response in infected patients is provided, and results show that viral pseudotyping can be employed for the analysis of SARS -CoV S function.
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