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Open AccessJournal ArticleDOI

Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction.

Tin-Yun Ho, +4 more
- 01 May 2007 - 
- Vol. 74, Iss: 2, pp 92-101
TLDR
Emodin, an anthraquinone compound derived from genus Rheum and Polygonum, significantly blocked the S protein and ACE2 interaction in a dose-dependent manner and suggested that emodin may be considered as a potential lead therapeutic agent in the treatment of SARS.
About: 
This article is published in Antiviral Research.The article was published on 2007-05-01 and is currently open access. It has received 354 citations till now. The article focuses on the topics: Emodin & Rheum officinale.

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Citations
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Journal ArticleDOI

Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: A review

Longfei Lin, +7 more
- 15 Jan 2015 - 
TL;DR: A systematic review of the literature on Polygonum multiflorum was performed using several resources, including classic books on Chinese herbal medicine and various scientific databases, to provide comprehensive information on the botany, traditional uses, phytochemistry, pharmacological research and toxicology of this plant.
Journal ArticleDOI

Natural product-derived phytochemicals as potential agents against coronaviruses: A review.

Janice S. Mani, +6 more
- 15 Jul 2020 - 
TL;DR: It was noted that the most promising small molecules identified as coronavirus inhibitors contained a conjugated fused ring structure with the majority being classified as being polyphenols.
Journal ArticleDOI

Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic.

Amin Gasmi, +5 more
- 07 Apr 2020 - 
TL;DR: The careful individual assessment for the possible dietary, nutritional, medical, lifestyle, and environmental risks, together with the proper relevant risk management strategies, is the sensible way to deal with the pandemic of SARS-CoV-II.
Journal ArticleDOI

Computers and viral diseases. Preliminary bioinformatics studies on the design of a synthetic vaccine and a preventative peptidomimetic antagonist against the SARS-CoV-2 (2019-nCoV, COVID-19) coronavirus.

Barry Robson
- 26 Feb 2020 - 
TL;DR: The genome of the Wuhan Seafood Market isolate believed to represent the causative agent of the disease COVID-19 is studied to find a short section or sections of viral protein sequence suitable for preliminary design proposal for a peptide synthetic vaccine and a peptidomimetic therapeutic, and to explore some design possibilities.
Journal ArticleDOI

Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities.

Siyu Xiu, +7 more
- 15 Jun 2020 - 
TL;DR: Treatment intervention strategies for anti-SARS-CoV, MERS- coV, and other coronaviruses are highlighted and future directions for SARS- CoV-2 entry inhibitor designs are speculated upon.
References
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Journal ArticleDOI

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.

Wenhui Li, +11 more
- 27 Nov 2003 - 
TL;DR: It is found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells, indicating that ACE2 is a functional receptor for SARS-CoV.
Journal ArticleDOI

Identification of a novel coronavirus in patients with severe acute respiratory syndrome.

Christian Drosten, +25 more
- 15 May 2003 - 
TL;DR: The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls.
Journal ArticleDOI

A novel coronavirus associated with severe acute respiratory syndrome.

Thomas G. Ksiazek, +25 more
- 15 May 2003 - 
TL;DR: A novel coronavirus is associated with this outbreak of severe acute respiratory syndrome, and the evidence indicates that this virus has an etiologic role in SARS.
Journal ArticleDOI

Coronavirus as a possible cause of severe acute respiratory syndrome

Jsm Peiris, +15 more
- 19 Apr 2003 - 
TL;DR: Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression.
Journal ArticleDOI

Characterization of a novel coronavirus associated with severe acute respiratory syndrome.

Paul A. Rota, +34 more
- 30 May 2003 - 
TL;DR: Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closelyrelated to any of the previouslycharacterized coronaviruses.
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