scispace - formally typeset
Open AccessJournal ArticleDOI

Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction.

Tin-Yun Ho, +4 more
- 01 May 2007 - 
- Vol. 74, Iss: 2, pp 92-101
TLDR
Emodin, an anthraquinone compound derived from genus Rheum and Polygonum, significantly blocked the S protein and ACE2 interaction in a dose-dependent manner and suggested that emodin may be considered as a potential lead therapeutic agent in the treatment of SARS.
About: 
This article is published in Antiviral Research.The article was published on 2007-05-01 and is currently open access. It has received 354 citations till now. The article focuses on the topics: Emodin & Rheum officinale.

read more

Citations
More filters
Journal ArticleDOI

Barbaloin: an amazing chemical from the ‘wonder plant’ with multidimensional pharmacological attributes

Shreya Sikdar Mitra, +9 more
- 29 Sep 2022 - 
TL;DR: Barbaloin belonging to the first group is a glucoside of the aloe-emodin anthrone molecule as discussed by the authors , it is an anthraquinone derivative and exists as an isomer of Aloin A and Aloin B. This study comprehensively focuses on the numerous pharmacological actions of the primary compound barbaloin obtained from the Aloe vera plant along with the mechanism of action and the potent application of natural molecules under various conditions.
Journal ArticleDOI

Assessment of the potential value of combining western medicine therapies with traditional chinese medicine in the treatment of COVID-19: Mechanistic perspectives

Zi-Ying Zeng
- 06 Apr 2023 - 
TL;DR: In this paper , a combination of TCM and traditional Chinese medicine was proposed for the treatment of the coronavirus disease (COVID-19) by analyzing their respective molecular targets.
Journal ArticleDOI

Emodin and rhapontigenin inhibit the replication of African swine fever virus by interfering with virus entry.

Yancheng Guo, +8 more
- 01 Jun 2023 - 
TL;DR: In this paper , the application of emodin and rhapontigenin (RHAG) in inhibiting African swine fever virus (ASFV) replication in-vitro was discussed.
Peer ReviewDOI

Insight into coronaviruses and natural products-based approach for COVID-19 treatment

Patil Shivprasad Suresh, +3 more
- 19 Jul 2022 - 
TL;DR: This chapter includes an overview of coronaviruses, their therapeutic targets, and the progress made in identifying lead natural products against the coronavirus, as well as molecular docking and pharmacokinetics analysis of anticoronaviral natural products have been performed to narrow down the possible lead molecules.
Journal ArticleDOI

Antiviral Phytocompounds: A Methodical Review of Therapeutic Efficiency Against SARS-Like Human Coronaviruses

Laskar Yahyea Baktiar, +6 more
TL;DR: It is observed that promising therapeutic outcome can be anticipated from at least fifteen traditionally used phytocompounds in the prevention and treatment of coronavirus diseases and its associated health complexities.
References
More filters
Journal ArticleDOI

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.

Wenhui Li, +11 more
- 27 Nov 2003 - 
TL;DR: It is found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells, indicating that ACE2 is a functional receptor for SARS-CoV.
Journal ArticleDOI

Identification of a novel coronavirus in patients with severe acute respiratory syndrome.

Christian Drosten, +25 more
- 15 May 2003 - 
TL;DR: The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls.
Journal ArticleDOI

A novel coronavirus associated with severe acute respiratory syndrome.

Thomas G. Ksiazek, +25 more
- 15 May 2003 - 
TL;DR: A novel coronavirus is associated with this outbreak of severe acute respiratory syndrome, and the evidence indicates that this virus has an etiologic role in SARS.
Journal ArticleDOI

Coronavirus as a possible cause of severe acute respiratory syndrome

Jsm Peiris, +15 more
- 19 Apr 2003 - 
TL;DR: Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression.
Journal ArticleDOI

Characterization of a novel coronavirus associated with severe acute respiratory syndrome.

Paul A. Rota, +34 more
- 30 May 2003 - 
TL;DR: Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closelyrelated to any of the previouslycharacterized coronaviruses.
Related Papers (5)

Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus

J. Cinatl, +5 more
- 14 Jun 2003 - 

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann, +13 more
- 16 Apr 2020 - 

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang, +28 more
- 24 Jan 2020 - 

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou, +28 more
- 03 Feb 2020 - 

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.

Manli Wang, +9 more
- 04 Feb 2020 -