Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction.
TLDR
Emodin, an anthraquinone compound derived from genus Rheum and Polygonum, significantly blocked the S protein and ACE2 interaction in a dose-dependent manner and suggested that emodin may be considered as a potential lead therapeutic agent in the treatment of SARS.Citations
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Plants as a Prospective Source of Natural Anti-viral Compounds and Oral Vaccines Against COVID-19 Coronavirus
Mahdi Yonesi,Alireza Rezazadeh +1 more
TL;DR: Plant species such as Scutellaria baicalensis (Baikal skullcap), and Utrica dioica (Stinging nettle) are considered as suitable candidates for the new coronavirus antiviral research and the use of plants such as Nicotiana tabacum (Tobacco) for the expression of the coronav virus viral antigens can be a target for the future vaccinal research.
Journal Article
Promising preventive and therapeutic effects of TaibUVID nutritional supplements for COVID-19 pandemic: towards better public prophylaxis and treatment (A retrospective study).
Salah Mohamed El Sayed,Salah Mohamed El Sayed,Moutasem Salih Aboonq,Amr Gamal El Rashedy,Yasmeen Talal Aljehani,Rabab M. Abou El-Magd,Ahmed M. Okashah,Mariam E El-Anzi,Mansour Barakah Alharbi,Rehab El-Tahlawi,Rehab El-Tahlawi,Manal Mohamed Helmy Nabo,Reda S Yousef,Momen Elshazley,Momen Elshazley,Mostafa Abu-Elnaga,Mostafa Abu-Elnaga,Hany Salah Mahmoud,Hassan El-Alaf,Abdelrahman I Abdelrahman,Abdelhady Ragab Abdel-Gawad,Tamer M Soliman +21 more
TL;DR: TaibUVID nutritional supplements are recommended for public prophylaxis (to decrease emergence of new cases) and treatment in COVID-19 pandemic.
Journal ArticleDOI
Edible and Herbal Plants for the Prevention and Management of COVID-19
Sha Li,Chien-Shan Cheng,Cheng Zhang,Guoyi Tang,Hor-Yue Tan,Hai-Yong Chen,Ning Wang,Agnes Y.K. Lai,Yibin Feng +8 more
TL;DR: In this paper, a review of promising candidates of edible and medicinal plants for the prevention and management of the pandemic coronavirus disease 2019 (COVID-19) is presented.
Journal ArticleDOI
Plant in vitro Culture Technologies;A Promise Into Factories of Secondary Metabolites Against COVID-19
Tariq Khan,Mubarak Ali Khan,Kashmala Karam,Nazif Ullah,Zia-ur-Rehman Mashwani,Akhtar Nadhman +5 more
TL;DR: In this article, the potential of different in vitro plant cultures to produce medicinally important secondary metabolites that could ultimately be helpful in the fight against COVID-19 was reviewed, focusing on the potential to produce medicinal compounds from different plants such as Isatis indigotica, Lindera aggregate, and Artemisia annua.
Journal ArticleDOI
Current Updates on Naturally Occurring Compounds Recognizing SARS-CoV-2 Druggable Targets.
TL;DR: In this article, a review aims to update on current status of the natural occurring compounds recognizing SARS-CoV-2 druggable targets, and some natural compounds are ongoing to examine their potential role to prevent and to treat the COVID-19 infection.
References
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Journal ArticleDOI
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
Wenhui Li,Michael Moore,Natalya Vasilieva,Jianhua Sui,Swee Kee Wong,Michael A. Berne,Mohan Somasundaran,John L. Sullivan,Katherine Luzuriaga,Thomas C. Greenough,Hyeryun Choe,Michael Farzan +11 more
TL;DR: It is found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells, indicating that ACE2 is a functional receptor for SARS-CoV.
Journal ArticleDOI
Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
Christian Drosten,Stephan Günther,Wolfgang Preiser,Sylvie van der Werf,H. R. Brodt,Stephan Becker,Holger F. Rabenau,Marcus Panning,Larissa Kolesnikova,Ron A. M. Fouchier,Annemarie Berger,Ana-Maria Burguière,Jindrich Cinatl,Markus Eickmann,Nicolas Escriou,Klaus Grywna,Stefanie Kramme,Jean-Claude Manuguerra,Stefanie Müller,Volker Rickerts,Martin Stürmer,Simon Vieth,Hans-Dieter Klenk,Albert D. M. E. Osterhaus,Herbert Schmitz,Hans Wilhelm Doerr +25 more
TL;DR: The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls.
Journal ArticleDOI
A novel coronavirus associated with severe acute respiratory syndrome.
Thomas G. Ksiazek,Dean D. Erdman,Cynthia S. Goldsmith,Zaki,Teresa C. T. Peret,Shannon L. Emery,Suxiang Tong,Urbani C,James A. Comer,Wilina Lim,Pierre E. Rollin,Scott F. Dowell,Ai Ee Ling,Charles D. Humphrey,Wun-Ju Shieh,Jeannette Guarner,Christopher D. Paddock,Paul A. Rota,Barry S. Fields,Joseph L. DeRisi,Jyh-Yuan Yang,Nancy J. Cox,James M. Hughes,James W. LeDuc,William J. Bellini,Larry J. Anderson +25 more
TL;DR: A novel coronavirus is associated with this outbreak of severe acute respiratory syndrome, and the evidence indicates that this virus has an etiologic role in SARS.
Journal ArticleDOI
Coronavirus as a possible cause of severe acute respiratory syndrome
Jsm Peiris,Sik To Lai,Llm Poon,Yi Guan,Lyc Yam,Wilina Lim,John M. Nicholls,Wks Yee,WW Yan,MT Cheung,V. C. C. Cheng,KH Chan,Dnc Tsang,R Yung,Ting Kin Ng,KY Yuen +15 more
TL;DR: Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression.
Journal ArticleDOI
Characterization of a novel coronavirus associated with severe acute respiratory syndrome.
Paul A. Rota,M. Steven Oberste,Stephan S. Monroe,W. Allan Nix,Ray Campagnoli,Joseph P. Icenogle,Silvia Peñaranda,Bettina Bankamp,Kaija Maher,Min hsin Chen,Suxiong Tong,Azaibi Tamin,Luis Lowe,Michael Frace,Joseph L. DeRisi,Qi Chen,David Wang,Dean D. Erdman,Teresa C. T. Peret,Cara C. Burns,Thomas G. Ksiazek,Pierre E. Rollin,Anthony Sanchez,Stephanie L. Liffick,Brian P. Holloway,Josef Limor,Karen A. McCaustland,Mellissa Olsen-Rasmussen,Ron A. M. Fouchier,Stephan Günther,Albert Osterhaus,Christian Drosten,Mark A. Pallansch,Larry J. Anderson,William J. Bellini +34 more
TL;DR: Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closelyrelated to any of the previouslycharacterized coronaviruses.
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