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Open AccessJournal ArticleDOI

Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction.

Tin-Yun Ho, +4 more
- 01 May 2007 - 
- Vol. 74, Iss: 2, pp 92-101
TLDR
Emodin, an anthraquinone compound derived from genus Rheum and Polygonum, significantly blocked the S protein and ACE2 interaction in a dose-dependent manner and suggested that emodin may be considered as a potential lead therapeutic agent in the treatment of SARS.
About: 
This article is published in Antiviral Research.The article was published on 2007-05-01 and is currently open access. It has received 354 citations till now. The article focuses on the topics: Emodin & Rheum officinale.

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Citations
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Journal ArticleDOI

Emodin inhibits current through SARS-associated coronavirus 3a protein

Silvia Schwarz, +4 more
- 01 Apr 2011 - 
TL;DR: It is demonstrated that emodin can inhibit the 3a ion channel of coronavirus SARS-CoV and HCoV-OC43 as well as virus release from H coV- OC43 with a K 1/2 value of about 20μM, suggesting that viral ion channels, in general, may be a good target for the development of antiviral agents.
Journal ArticleDOI

Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID-19: A review.

Bikash Adhikari, +9 more
- 01 Mar 2021 - 
TL;DR: Here, 93 antiviral drug candidates are reported which could be a potential area of research in drug discovery against COVID‐19 and these could also show promising inhibitory effects against influenza‐parainfluenza viruses, respiratory syncytial virus, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome coronavirus (MERS‐CoV).
Journal ArticleDOI

COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles' heel conserved region to minimize probability of escape mutations and drug resistance.

Barry Robson
- 01 Jun 2020 - 
TL;DR: Preliminary conformational analysis of the receptor (ACE2) binding site of the spike protein is carried suggesting that while it is somewhat conserved, it appears to be more variable than KRSFIEDLLFNKV, which might represent SARS-CoV-2 Achilles’ Heel.
Journal ArticleDOI

Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection.

Min Zhuang, +12 more
- 01 Apr 2009 - 
TL;DR: CC extracts contain anti-virus activities that act through distinct mechanisms according to differences in the compounds or mixtures, and CC/Fr.2 contains unknown substances, that could inhibit the infection, probably by interfering with endocytosis, and it also contains procyanidins that did not inhibit the internalization but inhibited the infection.
Journal ArticleDOI

Natural products for COVID-19 prevention and treatment regarding to previous coronavirus infections and novel studies.

Motahareh Boozari, +1 more
- 01 Feb 2021 - 
TL;DR: Regarding the effective herbal treatments on other coronavirus infections, promising natural products for COVID‐19 treatment are suggested and it seems that different types of terpenoids have promising effects in viral replication inhibition and could be introduced for future studies.
References
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Journal ArticleDOI

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.

Wenhui Li, +11 more
- 27 Nov 2003 - 
TL;DR: It is found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells, indicating that ACE2 is a functional receptor for SARS-CoV.
Journal ArticleDOI

Identification of a novel coronavirus in patients with severe acute respiratory syndrome.

Christian Drosten, +25 more
- 15 May 2003 - 
TL;DR: The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls.
Journal ArticleDOI

A novel coronavirus associated with severe acute respiratory syndrome.

Thomas G. Ksiazek, +25 more
- 15 May 2003 - 
TL;DR: A novel coronavirus is associated with this outbreak of severe acute respiratory syndrome, and the evidence indicates that this virus has an etiologic role in SARS.
Journal ArticleDOI

Coronavirus as a possible cause of severe acute respiratory syndrome

Jsm Peiris, +15 more
- 19 Apr 2003 - 
TL;DR: Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression.
Journal ArticleDOI

Characterization of a novel coronavirus associated with severe acute respiratory syndrome.

Paul A. Rota, +34 more
- 30 May 2003 - 
TL;DR: Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closelyrelated to any of the previouslycharacterized coronaviruses.
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