Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction.
TLDR
Emodin, an anthraquinone compound derived from genus Rheum and Polygonum, significantly blocked the S protein and ACE2 interaction in a dose-dependent manner and suggested that emodin may be considered as a potential lead therapeutic agent in the treatment of SARS.Citations
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Antiviral Activities of Halogenated Emodin Derivatives against Human Coronavirus NL63.
Monika Horvat,Martina Avbelj,María Beatriz Durán-Alonso,Mihailo Banjanac,Hrvoje Petković,Jernej Iskra +5 more
TL;DR: In this paper, an initial evaluation of the potential to improve the activity of emodin against human coronavirus NL63 (HCoV-NL63) and also to generate a set of initial SAR guidelines was carried out.
Journal ArticleDOI
Potential medicinal plant remedies and their possible mechanisms against COVID-19: A review
TL;DR: Traditional medicines used to prevent or treat SARS-CoV-2 infection are listed along with the plant parts as used by the traditional healers and the possible mechanisms responsible for this preventive or therapeutic outcome are identified.
Journal ArticleDOI
In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease
Piyush Kumar Kashyap,Mamta Thakur,Nidhi Singh,Deep Shikha,Shiv Shanker Kumar,Poonam Baniwal,Yogender S. Yadav,Minaxi Sharma,Kandi Sridhar,B. Stephen Inbaraj +9 more
TL;DR: The fundamentals of coronaviruses, the structures of SARS-CoV-2, and the mechanism of its entry into the host’s body have been discussed and the potential of flavonoids against crucial proteins involved in the coronavirus infectious cycle are reviewed.
Journal ArticleDOI
Recent advances in developing small-molecule inhibitors against SARS-CoV-2.
Rong Xiang,Zhengsen Yu,Yang Wang,Lili Wang,Shanshan Huo,Yanbai Li,Ruiying Liang,Qinghong Hao,Tianlei Ying,Yaning Gao,Fei Yu,Shibo Jiang +11 more
TL;DR: In this article, the authors summarized the potential therapeutic targets involved in the life cycle of the SARS-CoV-2 virus and summarized the small-molecule prophylactic and therapeutic agents that have been or are being developed for prevention and treatment of SARS infection.
Journal ArticleDOI
A Comprehensive Review and Perspective of Herbal Medicines in the Treatment of COVID-19
Afrasim Moin,S. Meenakshi,Syed Mohd Danish Rizvi,Nanhi Nandini,Talib Hussain,Arshad Hussain,G. S. Meghana,M. Manohar,P. Sathishbabu,D. V. Gowda +9 more
TL;DR: It is highlighted that natural therapeutics either alone or in combination could be used as alternative medicines to treat/prevent COVID-19 infection and their structures may offer clues for the development of anti-SARS-CoV-2 drugs.
References
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Journal ArticleDOI
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
Wenhui Li,Michael Moore,Natalya Vasilieva,Jianhua Sui,Swee Kee Wong,Michael A. Berne,Mohan Somasundaran,John L. Sullivan,Katherine Luzuriaga,Thomas C. Greenough,Hyeryun Choe,Michael Farzan +11 more
TL;DR: It is found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells, indicating that ACE2 is a functional receptor for SARS-CoV.
Journal ArticleDOI
Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
Christian Drosten,Stephan Günther,Wolfgang Preiser,Sylvie van der Werf,H. R. Brodt,Stephan Becker,Holger F. Rabenau,Marcus Panning,Larissa Kolesnikova,Ron A. M. Fouchier,Annemarie Berger,Ana-Maria Burguière,Jindrich Cinatl,Markus Eickmann,Nicolas Escriou,Klaus Grywna,Stefanie Kramme,Jean-Claude Manuguerra,Stefanie Müller,Volker Rickerts,Martin Stürmer,Simon Vieth,Hans-Dieter Klenk,Albert D. M. E. Osterhaus,Herbert Schmitz,Hans Wilhelm Doerr +25 more
TL;DR: The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls.
Journal ArticleDOI
A novel coronavirus associated with severe acute respiratory syndrome.
Thomas G. Ksiazek,Dean D. Erdman,Cynthia S. Goldsmith,Zaki,Teresa C. T. Peret,Shannon L. Emery,Suxiang Tong,Urbani C,James A. Comer,Wilina Lim,Pierre E. Rollin,Scott F. Dowell,Ai Ee Ling,Charles D. Humphrey,Wun-Ju Shieh,Jeannette Guarner,Christopher D. Paddock,Paul A. Rota,Barry S. Fields,Joseph L. DeRisi,Jyh-Yuan Yang,Nancy J. Cox,James M. Hughes,James W. LeDuc,William J. Bellini,Larry J. Anderson +25 more
TL;DR: A novel coronavirus is associated with this outbreak of severe acute respiratory syndrome, and the evidence indicates that this virus has an etiologic role in SARS.
Journal ArticleDOI
Coronavirus as a possible cause of severe acute respiratory syndrome
Jsm Peiris,Sik To Lai,Llm Poon,Yi Guan,Lyc Yam,Wilina Lim,John M. Nicholls,Wks Yee,WW Yan,MT Cheung,V. C. C. Cheng,KH Chan,Dnc Tsang,R Yung,Ting Kin Ng,KY Yuen +15 more
TL;DR: Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression.
Journal ArticleDOI
Characterization of a novel coronavirus associated with severe acute respiratory syndrome.
Paul A. Rota,M. Steven Oberste,Stephan S. Monroe,W. Allan Nix,Ray Campagnoli,Joseph P. Icenogle,Silvia Peñaranda,Bettina Bankamp,Kaija Maher,Min hsin Chen,Suxiong Tong,Azaibi Tamin,Luis Lowe,Michael Frace,Joseph L. DeRisi,Qi Chen,David Wang,Dean D. Erdman,Teresa C. T. Peret,Cara C. Burns,Thomas G. Ksiazek,Pierre E. Rollin,Anthony Sanchez,Stephanie L. Liffick,Brian P. Holloway,Josef Limor,Karen A. McCaustland,Mellissa Olsen-Rasmussen,Ron A. M. Fouchier,Stephan Günther,Albert Osterhaus,Christian Drosten,Mark A. Pallansch,Larry J. Anderson,William J. Bellini +34 more
TL;DR: Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closelyrelated to any of the previouslycharacterized coronaviruses.
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